化学学院-朱春雷课题组导师介绍
朱春雷课题组
研究员
硕，博士生导师
男
化学学院
高分子化学与物理
生物医用有机/高分子材料
chunlei.zhu@nankai.edu.cn
南开大学化学学院高分子化学研究所研究员、博士生导师，国家高层次人才青年项目入选者，南开大学百名青年学科带头人。朱春雷2008年本科毕业于吉林大学化学学院（指导老师：吴立新教授），同年保送至中国科学院化学研究所（指导老师：王树研究员），并于2013年取得理学博士学位。2014年至2017年，在美国佐治亚理工学院从事博士后研究（合作导师：夏幼南教授）。2017年至2018年，在香港科技大学从事博士后研究（合作导师：唐本忠院士）。目前，以第一和通讯作者在Chem. Rev., Chem. Soc. Rev., Nat. Rev. Chem., Acc. Chem. Res., PNAS, JACS, Angew. Chem. Int. Ed.（3）, Adv. Mater.（7）, Matter, Adv. Funct. Mater., Adv. Sci., Chem. Sci., CCS Chem., ACS Nano, J. Control. Release等期刊上发表学术论文43篇（其中中科院一区论文28篇），其他合作发表学术论文28篇，论文总引用6300余次，其中单篇最高引用大于1000次，H指数37。
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科研项目
研究成果
Scientific Papers
71. A pH-Responsive, Surface Charge-Switchable Nanosystem with Enhanced Biofilm Penetration for Synergistic Photodynamic and Antibiotic Therapy of Diabetic Wounds
Zhencheng Sun, Minghui Xiao, Shuyi Lv, Cheng Wang, Hao Fu, Liang Tian, Linqi Shi, and Chunlei Zhu*
Adv. Funct. Mater. 2024, ASAP.
70. A straightforward strategy to modulate ROS generation of AIE photosensitizers for type-I PDT
Zhencheng Sun, Jiaxin Wang, Minghui Xiao, Kaiyu Wu, Cheng Wang, Hao Fu, Shuyi Lv, Linqi Shi, and Chunlei Zhu*
Chem. Eng. J. 2024, 499, 155782.
DOI: 10.1016/j.cej.2024.155782.
69. Ultrasensitive Ratiometric Fluorescent Nanothermometer with Reverse Signal Changes for Intracellular Temperature Mapping
Ke Xue#, Siwei Huang#, Kaiyu Wu, Zhencheng Sun, Hao Fu, Cheng Wang, Chao Wang, and Chunlei Zhu*
Anal. Chem. 2024, 96, 11026–11035.
DOI: 10.1021/acs.analchem.4c01803.
68. A Self-Regulated Phototheranostic Nanosystem with Single Wavelength-Triggered Energy Switching and Oxygen Supply for Multimodal Synergistic Therapy of Bacterial Biofilm Infections
Cheng Wang, Shuyi Lv, Zhencheng Sun, Minghui Xiao, Hao Fu, Liang Tian, Xianhao Zhao, Linqi Shi, and Chunlei Zhu*
Aggregate 2024, 5, e587.
67. A Universal Strategy to Enhance Photothermal Conversion Efficiency by Regulating the Molecular Aggregation States for Safe Photothermal Therapy of Bacterial Infections
Hao Fu, Yongxin Zhang, Cheng Wang, Zhencheng Sun, Shuyi Lv, Minghui Xiao, Kaiyu Wu, Linqi Shi, and Chunlei Zhu*
Biomater. Sci. 2024, 12, 2914–2929.
66. 2023年度有机高分子材料学科国家自然科学基金管理工作综述及相关领域近期重要研究进展
丁玉琴,* 马劲, 饶静一, 朱春雷, 蔡芸皓
《高分子通报》, 2024, 37, 419–429.
DOI: 10.14028/j.cnki.1003-3726.2024.23.407.
65. Bacterial Patterning: A Promising Biofabrication Technique
Minghui Xiao, Shuyi Lv, and Chunlei Zhu*
ACS Appl. Bio Mater. 2024, 7, 8008–8018. (Invited for Early Career Forum 2024)
64. Photodynamic Patterning of Living Bacterial Biofilms with High Resolutions for Information Encryption and Antibiotic Screening
Minghui Xiao, Ke Xue, Hao Fu, Jiaxin Wang, Shuyi Lv, Zhencheng Sun, Cheng Wang, Linqi Shi, and Chunlei Zhu*
Aggregate 2024, 5, e532.
63. Reconstituting Low-Density Lipoprotein with NIR-Absorbing Organic Photothermal Agents for Targeted Killing of Cancer Cells
Jiaxin Wang#, Liang Tian#, Kaiyu Wu, Chao Wang, and Chunlei Zhu*
Macromol. Rapid Commun. 2023, 44, 2300395.
62. Activated alkyne-enabled turn-on click bioconjugation with cascade signal amplification for ultrafast and high-throughput antibiotic screening
Shuyi Lv, Chao Wang, Ke Xue, Jiaxin Wang, Minghui Xiao, Zhencheng Sun, Lei Han, Linqi Shi, and Chunlei Zhu*
Proc. Natl. Acad. Sci. U.S.A. 2023, 120, e2302367120.
61. 非电荷型AIE光敏剂的纳米封装及光动力抗菌研究
武凯宇, 孙振程, 符豪, 肖铭慧, 朱春雷*
60. Differentiation Therapy for Murine Myelofibrosis Model with MLN8237 Loaded Low-density Lipoproteins
Binghong He#, Chao Wang#, Fuping Wang, Liang Tian, Haitao Wang, Chunling Fu, Jin Liu, Chao Xi, Chunlei Zhu,* and Qiong Yang*
J. Control. Release 2023, 356, 554–566.
DOI: 10.1016/j.jconrel.2023.03.024.
59. Informatics colourizes polymers
Xiaolin Liu,* Chunlei Zhu,* and Ben Zhong Tang*
Nat. Rev. Chem. 2023, 7, 232–233.
DOI: 10.1038/s41570-023-00484-z.
58. Thermoresponsive Hydrogel-Enabled Thermostatic Photothermal Therapy for Enhanced Healing of Bacteria-Infected Wounds
Hao Fu, Ke Xue, Yongxin Zhang, Minghui Xiao, Kaiyu Wu, Linqi Shi, and Chunlei Zhu*
Adv. Sci. 2023, 10, 2206865.
57. Holdase/Foldase Mimetic Nanochaperone Improves Antibody-Based Cancer Immunotherapy
Yongxin Zhang, Hao Fu, Jiajing Chen, Linlin Xu, Yingli An, Rujiang Ma, Chunlei Zhu,Yang Liu, Feihe Ma*, and Linqi Shi*
Small Methods 2023, 7, 2201051.
56. NIR-II organic dyes: Get brighter and see clearer
Xiaolin Liu,* Jianhui Liu, and Chunlei Zhu*
Matter 2022, 5, 3583–3585.
DOI: 10.1016/j.matt.2022.10.005.
55. A Smart Photothermal Nanosystem with an Intrinsic Temperature-Control Mechanism for Thermostatic Treatment of Bacterial Infections
Jiaxin Wang, Boyi Hao, Ke Xue, Hao Fu, Minghui Xiao, Yongxin Zhang, Linqi Shi, and Chunlei Zhu*
Adv. Mater. 2022, 34, 2205653.
54. A Ratiometric Organic Fluorescent Nanogel Thermometer for Highly Sensitive Temperature Sensing
Chao Wang#, Xianhao Zhao#, Kaiyu Wu, Shuyi Lv, and Chunlei Zhu*
Biosensors 2022, 12, 702.
53. A receptor-targeting AIE photosensitizer for selective bacterial killing and real-time monitoring of photodynamic therapy outcome
Cheng Wang, Jiaxin Wang, Ke Xue, Minghui Xiao, Zhencheng Sun, and Chunlei Zhu*
Chem. Commun. 2022, 58, 7058–7061. (HOT Article)
52. Bridging D‒A type photosensitizers with the azo group to boost intersystem crossing for efficient photodynamic therapy
Boyi Hao, Jiaxin Wang, Chao Wang, Ke Xue, Minghui Xiao, Shuyi Lv, and Chunlei Zhu*
Chem. Sci. 2022, 13, 4139–4149.
51. Polarity-Sensitive Fluorescent Probe for Reflecting the Packing Degree of Bacterial Membrane Lipids
Chao Wang, Jiaxin Wang, Ke Xue, Minghui Xiao, Kaiyu Wu, Shuyi Lv, Boyi Hao, and Chunlei Zhu*
Anal. Chem. 2022, 94, 3303–3312.
DOI: 10.1021/acs.analchem.1c05268.
50. Bringing Inherent Charges into Aggregation-Induced Emission Research
Xiaolin Liu, Chunlei Zhu,* and Ben Zhong Tang*
Acc. Chem. Res. 2022, 55, 197–208. (Supplementary Cover)
DOI: 10.1021/acs.accounts.1c00630.
49. A Sensitive and Reliable Organic Fluorescent Nanothermometer for Noninvasive Temperature Sensing
Ke Xue, Chao Wang, Jiaxin Wang, Shuyi Lv, Boyi Hao, Chunlei Zhu,* and Ben Zhong Tang*
J. Am. Chem. Soc. 2021, 143, 14147–14157. (Front cover)
48. Heteroaromatic Hyperbranched Polyelectrolytes: Multicomponent Polyannulation and Photodynamic Biopatterning
Xiaolin Liu#, Minghui Xiao#, Ke Xue, Mingzhao Li, Dongming Liu, Yong Wang, Xinzhe Yang, Yubing Hu, Ryan T. K. Kwok, Anjun Qin, Chunlei Zhu,* Jacky W. Y. Lam,* and Ben Zhong Tang*
Angew. Chem. Int. Ed. 2021, 60, 19222–19231. (HOT paper & inside back cover)
47. Bringing naturally-occurring saturated fatty acids into biomedical research
Ke Xue#, Shuyi Lv#, and Chunlei Zhu*
J. Mater. Chem. B 2021, 9, 6973–6987. (Invited for 2021 Emerging Investigator Themed Issue & HOT paper)
46. Augmenting Tendon-to-Bone Repair with Functionally-Graded Scaffolds
Chunlei Zhu, Jichuan Qiu, Stavros Thomopoulos, and Younan Xia*
Adv. Healthcare Mater. 2021, 10, 2002269.
45. An Exceptional Broad-Spectrum Nanobiocide for Multimodal and Synergistic Inactivation of Drug-Resistant Bacteria
Ke Xue#, Cuihong Yang#, Chun Wang, Yang Liu, Jianfeng Liu,* Linqi Shi,* and Chunlei Zhu*
CCS Chem. 2022, 4, 272–285. (Front Cover)
DOI: 10.31635/ccschem.021.202000714.
44. Transporting mitochondrion-targeting photosensitizers into cancer cells by low-density lipoproteins for fluorescence-feedback photodynamic therapy
Chao Wang, Xianhao Zhao, Haoyu Jiang, Jiaxin Wang, Weixiu Zhong, Ke Xue, and Chunlei Zhu*
Nanoscale 2021, 13, 1195–1205. (Invited for 2021 Emerging Investigator Themed Issue)
43. Self-assembly of virulent amyloid-derived peptides into nanoantibacterials
Wenlu Tu, Ke Xue, Shaofeng Lou, Chunlei Zhu, and Zhilin Yu*
Nanoscale 2021, 13, 9864–9872.
42. 天然来源相转变材料在生物医药领域中的应用
朱春雷*
41. Self-Reporting and Photothermally Enhanced Rapid Bacterial Killing on a Laser-Induced Graphene Mask
Libei Huang, Siyu Xu, Zhaoyu Wang, Ke Xue, Jianjun Su, Yun Song, Sijie Chen, Chunlei Zhu,* Ben Zhong Tang,* and Ruquan Ye*
ACS Nano 2020, 14, 12045–12053.
40. Aggregation-induced emission: A trailblazing journey to the field of biomedicine
Chunlei Zhu, Ryan T. K. Kwok, Jacky W. Y. Lam, and Ben Zhong Tang*
ACS Appl. Bio Mater. 2018, 1, 1768–1786. (ACS Editor’s Choice)
Book Chapter
1. Chapter 9: Engineering the bioprobes with AIE properties to study tumor hypoxia
Jiaxin Wang and Chunlei Zhu*
Aggregation-Induced Emission: Applications in Biosensing, Bioimaging and Biomedicine–Volume I, Walter de Gruyter GmbH, 2022.
2. Chapter 11: Nanomedicine
Shuyi Lv and Chunlei Zhu
Handbook of Nanomaterials, Volume 2: Biomedicine, Environment, Food, and Agriculture, Elsevier, 2024.
Prior to joining Nankai University
39. Jiajia Xue, Tong Wu, Jianhua Li, Chunlei Zhu, and Younan Xia,* “Promoting the outgrowth of neurites on electrospun microfibers by functionalization with electrosprayed microparticles of fatty acids,” Angew. Chem. Int. Ed. 2019, 58, 3948–3951.
38. Qiaoshan Chen, Da Huo, Haoyan Cheng, Zhiheng Lyu, Chunlei Zhu, Baohong Guan, and Younan Xia,* “Near-infrared-triggered release of Ca2+ ions for potential application in combination cancer therapy,” Adv. Healthcare Mater. 2019, 8, 1801113.
37. Chunlei Zhu#, Suphannee Pongkitwitoon#, Jichuan Qiu, Stavros Thomopoulos, and Younan Xia,* “Design and fabrication of a hierarchically structured scaffold for tendon-to-bone repair,” Adv. Mater. 2018, 30, 1707306. (Back cover)
36. Chunlei Zhu#, Jichuan Qiu#, Suphannee Pongkitwitoon#, Stavros Thomopoulos, and Younan Xia,* “Inverse opal scaffolds with gradients in mineral content for spatial control of osteogenesis,” Adv. Mater. 2018, 30, 1706706.
35. Jiajia Xue, Chunlei Zhu, Jianhua Li, Haoxuan Li, and Younan Xia,* “Integration of phase-change materials with electrospun fibers for promoting neurite outgrowth under controlled release,” Adv. Funct. Mater. 2018, 28, 1705563.
34. Qiaoshan Chen, Chunlei Zhu, Da Huo, Jiajia Xue, Haoyan Cheng, Baohong Guan and Younan Xia,* “Continuous processing of phase-change materials into uniform nanoparticles for near-infrared-triggered drug release,” Nanoscale, 2018, 10, 22312–22318.
33. Haoyan Cheng, Da Huo, Chunlei Zhu, Song Shen, Wenxia Wang, Haoxuan Li, Zhihong Zhu, Younan Xia,* “Combination cancer treatment through photothermally controlled release of selenous acid from gold nanocages,” Biomaterials 2018, 178, 517–526.
32. Ji Qi, Chaowei Sun, Dongyu Li, Hequn Zhang, Wenbin Yu, Abudureheman Zebibula, Jacky W. Y. Lam, Wang Xi, Liang Zhu, Fuhong Cai, Peifa Wei , Chunlei Zhu, Ryan T. K. Kwok , Lina L. Streich, Robert Prevedel, Jun Qian,* and Ben Zhong Tang,* “Aggregation-induced emission luminogen with near-infrared-II excitation and near-infrared-I emission for ultradeep intravital two-photon microscopy,” ACS Nano 2018, 12, 7936–7945.
31. Tong Wu, Jiajia Xue, Haoxuan Li, Chunlei Zhu, Xiumei Mo, Younan Xia,* “A general method for generating circular gradients of active proteins on nanofiber scaffolds sought for wound closure and related applications,” ACS Appl. Mater. Interfaces 2018, 10, 8536–8535.
30. Chunlei Zhu and Younan Xia,* “Biomimetics: reconstitution of low-density lipoprotein for targeted drug delivery and related theranostic applications,” Chem. Soc. Rev. 2017, 46, 7668–7682.
29. Chunlei Zhu, Pallab Pradhan, Da Huo, Jiajia Xue, Song Shen, Krishnendu Roy, and Younan Xia,* “Reconstitution of low density lipoproteins with fatty acids for the targeted delivery of drugs into cancer cells,” Angew. Chem. Int. Ed. 2017, 56, 10399–10402.
28. Chunlei Zhu, Da Huo, Qiaoshan Chen, Jiajia Xue, Song Shen, and Younan Xia,* “A eutectic mixture of natural fatty acids can serve as the gating material for near-infrared-triggered drug release,” Adv. Mater. 2017, 29, 1703702.
27. Yu Shrike Zhang#, Chunlei Zhu#, and Younan Xia,* “Inverse opal scaffolds and their biomedical applications,” Adv. Mater. 2017, 29, 1701115.
26. Song Shen, Chunlei Zhu, Da Huo, Miaoxin Yang, Jiajia Xue, and Younan Xia,* “A hybrid nanomaterial for the controlled generation of free radicals and oxidative destruction of hypoxic cancer cells,” Angew. Chem. Int. Ed. 2017, 56, 8801-8804. (HOT paper & back cover)
25. Haoxuan Li, Chunlei Zhu, Jiajia Xue, Qinfei Ke, and Younan Xia,* “Enhancing the mechanical properties of electrospun nanofiber mats through controllable welding at the cross points,” Macromol. Rapid Commun. 2017, 38, 1600723.
24. Jiajia Xue, Junyu Yang, Deirdre Margaret O’Connor, Chunlei Zhu, Da Huo, Nicholas M. Boulis, and Younan Xia,* “Differentiation of bone marrow stem cells into Schwann cells for the promotion of neurite outgrowth on electrospun fibers,” ACS Appl. Mater. Interfaces 2017, 9, 12299−12310.
23. Chunlei Zhu, Jiajia Xue, Kyle D. Gilroy, Da Huo, Song Shen, and Younan Xia,* “Micropatterned polymer nanorod forests and their use for dual drug loading and regulation of cell adhesion,” ACS Appl. Mater. Interfaces 2016, 8, 34194-34197.
22. Jianhua Li, Stephen W. Linderman, Chunlei Zhu, Hong Liu, Stavros Thomopoulos, and Younan Xia,* “Surgical sutures with porous sheaths for the sustained release of growth factors,” Adv. Mater. 2016, 28, 4620-4624.
21. Shan Zhou, Jianhua Li, Kyle D. Gilroy, Jing Tao, Chunlei Zhu, Xuan Yang, Xiaojun Sun, and Younan Xia,* “Facile synthesis of silver nanocubes with sharp corners and edges in an aqueous solution,” ACS Nano 2016, 10, 9861-9870.
20. Jianhua Li, Miaoxin Yang, Xiaojun Sun, Xuan Yang, JiaJia Xue, Chunlei Zhu, Hong Liu, and Younan Xia,* “Micropatterning of the ferroelectric phase in a poly(vinylidenedifluoride) film by plasmonic heating with gold nanocages,” Angew. Chem. Int. Ed. 2016, 55, 13828-13832. (Back cover)
19. Chunlei Zhu, Qiong Yang,* Fengting Lv, Libing Liu, and Shu Wang,* “Conjugated polymer-coated bacteria for multimodal intracellular and extracellular anticancer activity,” Adv. Mater. 2013, 25, 1203-1208.
18. Liheng Feng, Chunlei Zhu, Huanxiang Yuan, Libing Liu,* Fengting Lv, and Shu Wang,* “Conjugated polymer nanoparticles: Preparation, properties, functionalization and biological applications,” Chem. Soc. Rev. 2013, 42, 6620-6633.
17. Chenyao Nie, Chunlei Zhu, Liheng Feng, Fengting Lv,* Libing Liu, and Shu Wang,* “Synthesis of a new conjugated polymer for DNA alkylation and gene regulation,” ACS Appl. Mater. Interfaces 2013, 5, 4549-4554.
16. Bing Wang, Chunlei Zhu, Libing Liu, Fengting Lv, Qiong Yang, and Shu Wang,* “Synthesis of a new conjugated polymer for cell membrane imaging by using an intracellular targeting strategy,” Polym. Chem. 2013, 4, 5212-5215.
15. Hui Chong, Chunlei Zhu, Jinzhao Song, Liheng Feng, Qiong Yang,* Libing Liu, Fengting Lv, and Shu Wang,* “Preparation and optical property of new fluorescent nanoparticles,” Macromol. Rapid Commun. 2013, 34, 736-742.
14. Chunlei Zhu, Libing Liu, Qiong Yang, Fengting Lv, and Shu Wang,* “Water-soluble conjugated polymers for imaging, diagnosis, and therapy,” Chem. Rev. 2012, 112, 4687-4735.
13 Qiong Yang, Ying Dong, Wei Wu, Chunlei Zhu, Hui Chong, Jiangyang Lu,* Dehai Yu, Libing Liu, Fengting Lv, and Shu Wang,* “Detection and differential diagnosis of colon cancer by a cumulative analysis of promoter methylation,” Nat. Commun. 2012, 3, 1206.
12. Huanxiang Yuan, Hui Chong, Bing Wang, Chunlei Zhu, Libing Liu,* Qiong Yang, Fengting Lv, and Shu Wang,* “Chemical molecule-induced light-activated system for anticancer and antifungal activities,” J. Am. Chem. Soc. 2012, 134, 13184-13187.
11. Quanshan Wen, Chunlei Zhu, Libing Liu,* Qiong Yang, Shu Wang,* and Daoben Zhu,* “Synthesis of a bifunctional fluorescent polymer for cell imaging and enzyme detection,” Macromol. Chem. Phys. 2012, 213, 2486-2491.
10. Hui Chong, Chenyao Nie, Chunlei Zhu, Qiong Yang,* Libing Liu, Fengting Lv, and Shu Wang,* “Conjugated polymer nanoparticles for light-activated anticancer and antibacterial activity with imaging capability,” Langmuir 2012, 28, 2091-2098.
9. Bing Wang, Huanxiang Yuan, Chunlei Zhu, Qiong Yang,* Fengting Lv, Libing Liu, and Shu Wang,* “Polymer-drug conjugates for intracellar molecule-targeted photoinduced inactivation of protein and growth inhibition of cancer cells,” Sci. Rep. 2012, 2, 766.
8. Gaomai Yang, Huanxiang Yuan, Chunlei Zhu, Libing Liu,* Qiong Yang, Fengting Lv, and Shu Wang,* “New conjugated polymers for photo-induced unwinding of DNA supercoiling and gene regulation,” ACS Appl. Mater. Interfaces 2012, 4, 2334-2337.
7. Chunlei Zhu, Qiong Yang,* Libing Liu, and Shu Wang,* “Rapid, simple and high-throughput antimicrobial susceptibility testing and antibiotics screening,” Angew. Chem. Int. Ed. 2011, 50, 9607-9610.
6. Chunlei Zhu, Qiong Yang,* Libing Liu, Fengting Lv, Shayu Li, Guoqiang Yang, and Shu Wang,* “Multifunctional cationic poly(p-phenylene vinylene) polyelectrolytes for selective recognition, imaging and killing of bacteria over mammalian cells,” Adv. Mater. 2011, 23, 4805-4810. (Frontispiece)
5. Chunlei Zhu, Qiong Yang,* Libing Liu, and Shu Wang,* “A potent fluorescent probe for the detection of cell apoptosis,” Chem. Commun. 2011, 47, 5524-5526.
4. Chunlei Zhu, Qiong Yang,* Libing Liu, and Shu Wang,* “Visual optical discrimination and detection of microbial pathogens based on diverse interactions of conjugated polyelectrolytes with cells,” J. Mater. Chem. 2011, 21, 7905-7912. (HOT paper & front cover)
3. Chunlei Zhu, Qiong Yang, Libing Liu, and Shu Wang,* “Conjugated polymers for sensitive chemical sensors,” Prog. Chem. 2011, 23, 1993-2002.
2. Qiong Yang,* Tian Qiu, Wei Wu, Chunlei Zhu, Libing Liu, Jianming Ying,* and Shu Wang,* “Simple and sensitive method for detecting point mutations of epidermal growth factor receptor using cationic conjugated polymers,” ACS Appl. Mater. Interfaces 2011, 3, 4539-4545.
1. Qingling Xu, Chunxian Wu, Chunlei Zhu, Xinrui Duan, Libing Liu,* Yuchun Han, Yilin Wang,* and Shu Wang,* “A water-soluble conjugated polymer for protein identification and denaturation detection,” Chem. Asian J. 2010, 5, 2524-2529.
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学校介绍
南开大学是教育部直属重点综合性大学，是敬爱的周恩来总理的母校。新中国成立以来，学校发展始终得到党和国家的亲切关怀。毛泽东主席题写校名、亲临视察；周恩来总理三回母校指导；邓小平同志会见数学大师陈省身，批示成立南开数学研究所；江泽民同志、胡锦涛同志先后视察南开。特别是党的十八大以来，习近平总书记多次对南开的发展给予肯定，并对相关工作回信和勉励，更在百年校庆之际亲临南开视察。
南开大学由严修、张伯苓秉承教育救国理念创办，肇始于1904年，成立于1919年。1937年校园遭侵华日军炸毁，学校南迁。1938年与北京大学、清华大学合组西南联合大学，被誉为“学府北辰”。1946年回津复校并改为国立。
新中国成立后，经历高等教育院系调整，成为文理并重的全国重点大学。改革开放以来，天津对外贸易学院、中国旅游管理干部学院相继并入，经教育部与天津市共建支持，学校发展成为国家“211工程”和“985工程”重点建设的综合性研究型大学。2015年9月，新校区建成启用后，初步形成了八里台校区、津南校区、泰达学院“一校三区”办学格局。2017年9月，入选国家42所世界一流大学建设高校，且为36所A类高校之一。
南开大学坚持“允公允能，日新月异”的校训，弘扬“爱国、敬业、创新、乐群”的传统和“文以治国、理以强国、商以富国”的理念，以“知中国，服务中国”为宗旨，以杰出校友周恩来为楷模，作育英才，繁荣学术，强国兴邦，传承文明，努力建设世界一流大学。
南开大学占地443.12万平方米，其中八里台校区占地121.60万平方米，津南校区占地245.89万平方米，泰达学院占地6.72万平方米。校舍建筑总面积195.19万平方米。按照“独立办学、紧密合作”的原则，与天津大学全面合作办学。
南开大学是国内学科门类齐全的综合性、研究型大学之一。在长期办学过程中，形成了文理并重、基础宽厚、突出应用与创新的办学特色。有专业学院26个，学科门类覆盖文、史、哲、经、管、法、理、工、农、医、教、艺等。
南开大学拥有一支公能兼备、业务精湛、奋发有为、充满活力的师资队伍。有专任教师2202人。其中，博士生导师885人、硕士生导师783人，教授898人、副教授857人。
南开大学具备培养学士、硕士和博士的完整教育体系。有在校学生31418人，其中本科生17005人，硕士研究生10299人，博士研究生4114人。有网络专科学生40230人，网络本科学生73029人。
学校积极构建和发展适应21世纪经济社会发展和人才培养需要的学科体系，有本科专业93个（其中国家级特色专业18个），硕士学位授权一级学科11个，硕士专业学位授权点27个，博士学位授权一级学科31个，不在一级学科覆盖下的二级博士点1个，博士后科研流动站28个。有国家“双一流”建设学科5个，一级学科国家重点学科6个（覆盖35个二级学科），二级学科国家重点学科9个，一级学科天津市重点学科32个，国家级一流本科专业建设点21个，省级一流本科专业建设点2个。有国家重点实验室2个，国家工程研究中心1个，国家地方联合工程研究中心1个，2011协同创新中心3个。教育部重点实验室7个，教育部工程研究中心3个，教育部国际合作联合实验室2个，国家环境保护重点实验室1个，国家人权教育与培训基地1个，教育部人文社会科学重点研究基地6个，省部共建协同创新中心1个，教育部国别和区域研究基地7个（培育基地1个、备案基地6个），示范性国家国际科技合作基地4个。国家级实验教学示范中心5个，国家级虚拟仿真实验教学中心2个，国家虚拟仿真实验教学项目2项，国家基础学科人才培养和科学研究基地9个，国家教材建设重点研究基地1个，国家大学生文化素质教育基地1个，中华传统文化传承基地2个，国家创新人才培养示范基地1个。天津市重点实验室20个，天津市工程技术中心4个，天津市普通高等学校实验教学示范中心14个，天津市普通高等学校实验教学示范中心建设单位1个，天津市国际科技合作基地22个，天津市人文社科重点研究基地9个，天津市高校智库8个，天津市社科实验室5个，天津市爱国主义教育基地1个。
有中国科学院院士11人，中国工程院院士4人，发展中国家科学院院士8人，教育部“长江学者奖励计划”特聘教授44人、青年学者19人，“国家杰出青年科学基金”获得者57人、“国家优秀青年科学基金”获得者39人，国家“万人计划”领军人才27人、青年拔尖人才15人，国家“百千万人才工程”入选者30人，教育部“跨世纪人才基金”获得者21人、“新世纪优秀人才支持计划”入选者158人，国家级有突出贡献的专家22人，国务院学位委员会学科评议组成员16人，国家自然科学基金创新研究群体负责人6人，“国家高技术研究发展计划（863计划）”首席科学家3人，“国家重点基础研究发展计划（973计划）”首席科学家15人，国家重点研发计划项目负责人24人。国家级教学名师奖获得者7人，国家级教学团队9个，教育部“高校青年教师奖”获得者8人。天津市杰出人才8人，天津市“人才发展特殊支持计划”领军人才3人、青年拔尖人才11人、高层次创新创业团队带头人11人，天津市有突出贡献专家7人，天津市杰出津门学者3人，天津市“131”创新人才培养工程第一层次人选63人、创新型人才团队带头人17人，“天津市杰出青年科学基金”获得者40人，天津市级教学名师奖获得者35人，天津市级教学团队18个。
南开大学既是教学中心，又是科研中心，取得了一批国内外公认的优秀成果。2019年，周其林院士领衔完成的“高效手性螺环催化剂的发现”项目获国家自然科学奖一等奖。2007—2018年以第一单位获得国家自然科学二等奖4项，国家科技进步二等奖1项，国家技术发明二等奖1项。获国家教学成果奖46项，国家级精品资源共享课31门，国家级精品视频公开课15门，国家级一流本科课程31门，中国专利优秀奖1项，中国青年科技奖2项，全国百篇优秀博士论文累计入选20篇。2018年以来，南开学者团队以第一完成单位在Science上发表研究论文6篇。
南开大学秉承“知中国，服务中国”的优良传统，立足“四个服务”职责使命，聚焦“一带一路”、京津冀协同发展、雄安新区建设等国家和区域发展战略，积极发挥学科、人才和技术优势，努力为国家和地方经济社会发展服务。习近平新时代中国特色社会主义思想研究院、21世纪马克思主义研究院、亚太经济合作组织研究中心、中国新一代人工智能发展战略研究院、经济与社会发展研究院、滨海开发研究院、人权研究中心、津南研究院、统计研究院、生态文明研究院等研究机构是国家有关部委和地方政府的“智囊团”和“人才库”。学校按照“国家急需，世界一流”的原则，全面对接“创新驱动发展”战略、“中国制造2025”等的实施，积极推动各类协同创新中心和若干高层次交叉科学中心建设，与一批高校、企业、科研院所、政府部门建立了紧密合作关系。
南开大学重视学生德、智、体、美、劳全面发展，构建南开特色的“公能”素质教育体系，探索“课堂教学－校园文化－社会实践”三位一体育人模式。以“注重素质、培养能力、强化基础、拓宽专业、严格管理、保证质量”为教学指导思想，实行弹性学制、学分制、主辅修制、双学位制。注重培育优良校风，大力加强校园文化建设，为学生营造丰富高雅、活泼向上的成长氛围。推进创新创业教育，开办“创业班”，推进“南开大学学生创新创业实践基地”建设，提升学生创新能力，助力学生创业计划落地。大力开展“师生同行”社会实践，搭建师生“受教育、长才干、作贡献”的互动平台。南开毕业生以专业基础扎实、综合素质全面、富于开拓精神和实践能力而受到社会各界青睐。
南开大学有着广泛的国际影响，与320多所国际知名大学和国际学术机构建立了合作与交流关系；有专兼职外国专家400余人，以及来自114个国家和地区的2000余名留学生在校学习；承建了英国格拉斯哥大学孔子学院等8所海外孔子学院；与英国牛津大学、伯明翰大学、韩国SK集团共建国际联合研究中心；与世界经济论坛（达沃斯论坛）、全球大学领导者论坛（GULF）、国际公立大学联盟（IFPU）、国际大学联合会（IAU）、世界工程组织联合会（WFEO）等国际组织保持着密切联系，通过积极参与各类国际组织活动，进一步推动与世界一流大学、机构的实质性、深层次合作。
南开大学先后授予数学家陈省身、物理学家吴大猷、经济学家扬·米尔达尔、美国科学院院士蒋－卡洛·若塔、哈佛大学医学院教授摩斯·居达·福克曼、台湾海基会前董事长江丙坤、美国莱斯大学校长李达伟、世界经济论坛主席克劳斯·施瓦布、新加坡总统陈庆炎、法国宪法委员会主席洛朗·法比尤斯等10位国际著名人士名誉博士称号。诺贝尔奖获得者杨振宁、李政道、罗伯特·蒙代尔、彼得·杜赫提、卡尔·巴里·夏普莱斯、弗农·洛马克斯·史密斯、罗伯特·恩格尔、巴里·詹姆斯·马歇尔、托马斯·萨金特，美国前国务卿基辛格，韩国前总统金大中，欧盟委员会前主席、意大利前总理罗马诺·普罗迪，著名作家金庸等被聘为名誉教授，一批海内外知名学者、著名政治家、企业家任客座教授、兼职教授。
南开大学将深入贯彻落实习近平总书记来校视察重要讲话精神，全面贯彻党的教育方针，坚持社会主义办学方向，落实立德树人根本任务，践行“四个服务”重要使命，加快建设南开品格、中国特色、世界一流大学，培养德智体美劳全面发展的社会主义建设者和接班人，为实现中华民族伟大复兴做出新一代南开人的历史贡献。
（数据截至2020年12月）
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