主要研究方向

元素有机化合物和有机氟溶剂环境中的物理有机化学；催化反应机理的实验与理论研究，和新型反应光/电反应机制的探索发现；面向国家战略需求和人民健康需要的含氟有机分子、含氟材料和催化剂开发

导师/课题组简介

刘天飞，2020年12月入职南开大学担任特聘研究员，博士生导师，国家“四青”人才、天津市“青年”人才等。

刘天飞课题组致力于物理有机化学和有机氟化学交叉领域的基础研究。主要方向包括：元素有机化合物和有机氟溶剂环境中的物理有机化学；催化反应机理的实验与理论研究，和新型反应光/电反应机制的探索发现；面向国家战略需求和人民健康需要的含氟有机分子、含氟材料和催化剂开发等。

办公室地址：天南楼D303

实验室地址：天南楼D904

邮箱：tianfeiliu@nankai.edu.cn

实验活动

团队活动   

在研国家级项目：

1.       国家重点研发计划，2022YFB4101800，“煤炭清洁高效利用技术”专项“CO2定向转化制含氧化学品反应机制与新途径”项目，2022-12-01至2026.11.30，在研，参与（55万元）

2.       国家自然科学基金委员会, 重大项目, 22193014, 自由基新反应的工业应用研究, 2022-01-01 至 2026-12-31, 374万元, 在研, 参与（89万元） 

3.       国家自然科学基金委员会, 面上项目, 22171141, 惰性极性含氟芳香溶剂中平衡酸度（pKa）和键解离 自由能数据库的建立, 2022-01-01 至 2025-12-31, 60万元, 在研, 主持

在研国家级项目：

1.       国家重点研发计划，2022YFB4101800，“煤炭清洁高效利用技术”专项“CO2定向转化制含氧化学品反应机制与新途径”项目，2022-12-01至2026.11.30，在研，参与（55万元）

2.       国家自然科学基金委员会, 重大项目, 22193014, 自由基新反应的工业应用研究, 2022-01-01 至 2026-12-31, 374万元, 在研, 参与（89万元） 

3.       国家自然科学基金委员会, 面上项目, 22171141, 惰性极性含氟芳香溶剂中平衡酸度（pKa）和键解离 自由能数据库的建立, 2022-01-01 至 2025-12-31, 60万元, 在研, 主持

独立成立课题组后发表的论文：  

13. Tianxing Lin, Tianfei Liu*, Research Advances in The Synthetic Methodologies of N-trifluoromethylamides, Chin. J. Org. Chem., 2025, just acceptted. 

https://sioc-journal.cn/Jwk_yjhx/CN/10.6023/cjoc202409003

12. Xiangmei Kong, Yunfei Liang, Zhenbo Guo, Tianxing Lin, Shan Liu, Zhiyi Liu, Tianfei Liu*, Jin-Pei Cheng, Determination of pKa values of C-H bonds in polar fluorinated arenes referred to a new CF3SO2-substituted anchor compound, ChemSusChem, 2024, e202402041.

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cssc.202402041

11. Lihuang Xie, Wenchao Liu, Zhenbo Guo, Qinbo Jiao, Xiaomin Shen, Tianfei Liu and Chunfa Xu*, A Stereoselective Organocatalyzed C-Glycosylation of Indole: Implications of Acceptor-Catalyst-Donor Interaction, Org. Chem. Front., 2025,12, 509-515 Manuscript https://doi.org/10.1039/D4QO01873G

10. Shan Liu§, Guang-Ning Pan§, Yijing Ling, Feng Gao, Yin Yang, Ganglong Cui*, Qilong Shen*, Tianfei Liu*, Difluorocarbene Generation via a Spin-Forbidden Excitation under Visible Light Irradiation, J. Am. Chem. Soc., 2024, 146, 45, 31094–31105. 

https://doi.org/10.1021/jacs.4c10939 

9. Zhenbo Guo, Zhicheng Zhang, Yuchen Huang, Tianxing Lin, Yixin Guo, Liang-Nian He, Tianfei Liu*, CO2 Valorization in Deep Eutectic Solvents, ChemSusChem, 2024, 17, e202400197. 

https://chemistry-europe.onlinelibrary.wiley.com/doi/10.1002/cssc.202400197

8. Shan Liu, Yin Yang, Tianfei Liu*, The aggregation behaviors of organic radicals in polar fluorinated arenes, Aggregate, 2024, 5, e543.

https://onlinelibrary.wiley.com/doi/10.1002/agt2.543 

7. Isaac N. Cloward, Tianfei Liu, Jamie Rose, Tamara Jurado, Annabell G. Bonn, Matthew B. Chambers, Catherine L. Pitman, Marc A. ter Horst, and Alexander J. M. Miller* Catalyst Self-Assembly Accelerates Bimetallic Light-Driven Electrocatalytic H2 Evolution in Water, Nature Chemistry, 2024, 16, 709–716

https://www.nature.com/articles/s41557-024-01483-3

6. Qinbo Jiao, Zhenbo Guo, Mingwen Zheng, Wentao Lin, Yujie Liao, Weitao Yan, Tianfei Liu,* and Chunfa Xu,* Anion-Bridged Dual Hydrogen Bond Enabled Concerted Addition of Phenol to Glycal, Adv. Sci., 2024, 11, 2308513.

https://onlinelibrary.wiley.com/doi/10.1002/advs.202308513 

5. Zijie Zhou, Yixin Guo, Xiangmei Kong, Ying Wang, Tianfei Liu*, Control of electron coupling and electron transfer through non-covalent interactions in mixed-valence systems, Chapter 11 of Wiley book "Mixed-Valence Systems - Fundamentals, Synthesis, Electron Transfer, and Applications", 2023-03-10. ISBN-10: ‎3527349804, ISBN-13: ‎978-3527349807.  https://onlinelibrary.wiley.com/doi/10.1002/9783527835287.ch11

4. Xiangmei Kong, Yixin Guo, Zijie Zhou, Tianfei Liu*, Mixed-Valence complexes in Biological and Bio-mimic Systems, Chapter 10 of Wiley book "Mixed-Valence Systems - Fundamentals, Synthesis, Electron Transfer, and Applications", 2023-03-10. ISBN-10: ‎3527349804, ISBN-13: ‎978-3527349807. https://onlinelibrary.wiley.com/doi/10.1002/9783527835287.ch10

3. Zhanyou Xu, Mingzi Sun, Zhongshuo Zhang, Yi Xie, Hongshuai Hou, Xiaobo Ji, Tianfei Liu, Bolong Huang*, Ying Wang*. Steering the Selectivity of Electrochemical CO2 Reduction in Acidic Media. ChemCatChem, 2022, 14, 202200052.

https://chemistry-europe.onlinelibrary.wiley.com/doi/full/10.1002/cctc.202200052

2. Zhiyi Liu, Yijun Sun, Tianfei Liu*. Recent advances in synthetic methodologies to form C-18F bonds. Front. Chem. 2022, 10, Article 883866. https://www.frontiersin.org/articles/10.3389/fchem.2022.883866/full 

1. Zijie Zhou, Xiangmei Kong, Tianfei Liu*. The Applications of PCET in Organic Synthesis[J]. Chin. J. Org. Chem. 2021, 41, 3844. 

http://sioc-journal.cn/Jwk_yjhx/CN/10.6023/cjoc202106001

 独立成立课题组前的代表论文：  

1. Robin Tyburski (contributed equally), Tianfei Liu (contributed equally), Starla D. Glover*, Leif Hammarström*, Proton-Coupled Electron Transfer Guidelines Fair and Square, J. Am. Chem. Soc., 2021, 143, 560.

https://pubs.acs.org/doi/full/10.1021/jacs.0c09106

Highlighted by X-mol:

https://www.x-mol.com/news/517093

2. Tianfei Liu(contributed equally), Robin Tyburski(contributed equally), Shihuai Wang, Ricardo Fernández-Terán, Sascha Ott, Leif Hammarström*, Elucidating Proton-Coupled Electron Transfer Mechanisms of Metal Hydrides with Free-Energy and Pressure Dependent Kinetics, J. Am. Chem. Soc., 2019, 141, 17245.

https://pubs.acs.org/doi/abs/10.1021/jacs.9b08189

Highlighted by X-mol: 

https://www.x-mol.com/news/19129

3. Tianfei Liu, Meiyuan Guo, Andreas Orthaber, Reiner Lomoth, Marcus Lundberg, Sascha Ott and Leif Hammarström*, Accelerating Proton-Coupled Electron Transfer of Metal Hydrides in Catalyst Model Reactions, Nat. Chem., 2018, 10, 881.

https://www.nature.com/articles/s41557-018-0076-x

Highlighted by X-mol:

https://www.x-mol.com/news/13561

https://skleoc.nankai.edu.cn/info/1019/4100.htm

https://chem.nankai.edu.cn/2019/0906/c24385a377311/page.htm

https://www.x-mol.com/groups/Tianfei_Liu