导师风采
谢建华
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  • 导师类别:硕士,博士生导师
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  • 所属院系:化学学院
  • 所属专业: 有机化学
  • 邮箱 : jhxie@nankai.edu.cn
  • 工作电话 : 022-23508049

个人简介

Personal Profile

1992年在四川师范学院获得理学学士学位。随后到四川泸州市护国中学和纳溪中学从事了2年教育工作。1997年在南开大学元素有机化学研究所获得硕士学位,并到成都地奥制药公司从事新药合成研究。2003年在南开大学元素有机化学研究所获得博士学位,随后留校工作至今,历任讲师、副研究员、研究员和博士生导师。2007-2008年在美国马里兰大学M. P. Doyle教授课题组做博士后研究。分别于2007年和2013年两次获得天津市自然科学一等奖(排名第二);2008年获得教育部“新世纪人才计划”支持;2012年获得“Thieme Chemistry Journals Award”;2013年得到了国家自然科学杰出青年基金资助;2019年获得国家自然科学奖一等奖(排名第二)。目前主要开展不对称催化新反应和新方法以及手性药物和天然产物分子不对称合成研究。发展了系列羰基化合物的高效不对称催化氢化新反应,实现了加兰他敏、文殊兰碱、Gracilamine、Hamigeran B、Hapalindole Q、Mulinane型二萜等手性天然产物分子的不对称全合成。已发表包括J. Am. Chem. Soc., Angew. Chem. Int. Ed., Chem. Sci., Org. Lett.等在内的学术论文120余篇。


  • 研究方向Research Directions
不对称催化及手性药物和天然产物合成
2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。
科研项目

(1)    国家自然科学基金委员会,重大研究计划培育项目,多环酮动态动力学拆分不对称催化氢化反应研究,2021-01至2023-12,在研,主持

(2)    国家自然科学基金委员会,面上项目,几类多环天然产物不对称全合成研究,2019-01至2022-12,在研,主持
(3)    国家自然科学基金委员会,重点项目,21532003,不对称催化动力学拆分及应用研究,2016-01至2020-12,已结题,参加
(4)    国家自然科学基金委员会,创新群体项目,21421062,杂原子有机化学,2014-01至2017-12,已结题,参加
(5)    国家自然科学基金委员会,杰出青年基金项目,21325207,不对称催化合成,2014-01至2017-12,已结题,主持
(6)    国家自然科学基金委员会,面上项目,21272120,石蒜科和莲花烷生物碱的不对称催化合成,2013-01至2016-12,已结题,主持
(7)    国家自然科学基金委员会,重点项目,21032003,高效不对称催化反应及其在天然产物和手性药物合成中的应用研究,2011-01至2014-12,已结题,参加
(8)    国家自然科学基金委员会,面上项目,20972071,高效不对称催化氢化反应及其在天然生物碱合成中的应用研究,2010-01至2012-12,已结题,主持
(9)    国家自然科学基金委员会,重点项目,20532010,用于高对映选择性有机反应的新型手性催化剂研究,2006-01至2009-12,已结题,参加
(10) 国家自然科学基金委员会,面上项目,20572049,新型手性双膦/双胺—过渡金属催化剂的合成及应用研究,2006-01至2008-12,已结题,主持
(11) 国家自然科学基金委员会,面上项目,20272026,高效单齿手性磷配体及其催化剂研究,2003-01至2005-12,已结题,参加


研究成果

1.       Liu-Yang Pu, Fan Yang, Ji-Qiang Chen, YingXiong, Huai-Yu Bin, Jian-Hua Xie*, Qi-Lin Zhou*, Enantioselective TotalSyntheses of Pentacyclic Homoproaporphine Alkaloids. Org. Lett. 2020, 22,7526-7530.

2.       Yun-YuHua, Huai-Yu Bin, Tao Wei, Hou-An Cheng, Zu-Peng Lin, Xing-Feng Fu, Yuan-QiangLi, Jian-Hua Xie*, Pu-Cha Yan*, Qi-Lin Zhou. Iridium-Catalyzed AsymmetricHydrogenation of γ- and δ-Ketoacids for Enantioselective Synthesis of γ- and δ-Lactones.Org. Lett. 2020, 22, 818-822.

3.       Xue-SongGu, Na Yu, Xiao-Hui Yang, An-Te Zhu, Jian-Hua Xie*, Qi-Lin Zhou.Enantioselective Hydrogenation of Racemic a-ArylaminoLactones to Chiral Amino Diols with Site-Specifically Modified Chiral SpiroIridium Catalysts. Org. Lett. 2019, 21, 4111-4115.

4.       Huai-YuBin, Ke Wang, Dan Yang, Xiao-Hui Yang, Jian-Hua Xie,* Qi-Lin Zhou. ScalableEnantioselective Total Synthesis of (‐)‐Goniomitine. Angew. Chem., Int. Ed. 2019,58, 1174-1177.

5.       Yang-MingZhang, Ming-Lei Yuan, Wei-Peng Liu, Jian-Hua Xie,* and Qi-Lin Zhou.Iridium-Catalyzed Asymmetric Transfer Hydrogenation of Alkynyl Ketones UsingSodium Formate and Ethanol as Hydrogen Sources, Org. Lett.2018, 20, 4486-4489.

6.       Xiao-DongZuo, Shu-Min Guo, Rui Yang, Jian-Hua Xie*, Qi-Lin Zhou, Asymmetric TotalSynthesis of Gracilamine and Determination of Its Absolute Configuration, Org.Lett. 2017, 19, 5240-5243.

7.       Yun-Ting Liu, Lin-PingLi, Jian-Hua Xie*, Qi-Lin Zhou, Divergent Asymmetric TotalSynthesis of Mulinane Diterpenoids,Angew. Chem. Int. Ed. 2017 56,12708-12711.

8.       Xiao-DongZuo, Shu-Min Guo, Rui Yang, Jian-Hua Xie*, Qi-Lin Zhou*, BioinspiredEnantioselective Synthesis of Crinine-type Alkaloids via Iridium-CatalyzedAsymmetric Hydrogenation of Enones, Chem.Sci. 2017, 8, 6202-6206.

9.       Yun-TingLiu, Ji-Qiang Chen, Lin-Ping Li, Xin-Yang Shao, Jian-Hua Xie*, Qi-Lin Zhou, AsymmetricHydrogenation of Tetrasubstituted Cyclic Enones to Chiral Cycloalkanols withThree Contiguous Stereocenters, Org. Lett.2017, 19, 3231-3234.

10.    Deng-Hui Bao, Xue-Song Gu, Jian-Hua Xie*, Qi-LinZhou*. Iridium-CatalyzedAsymmetric Hydrogenation of Racemic β-Keto Lactams via Dynamic KineticResolution, Org. Lett. 2017, 19,118-121.

11.     Xiao-Hui Yang, Hai-Tao Yue, Na Yu, Yi-Pan Li, Jian-HuaXie*, Qi-Lin Zhou*. Iridium-Catalyzed Asymmetric Hydrogenation of Racemic α-SubstitutedLactones to Chiral Diols, Chem. Sci. 2017, 8, 1811-1814.

12.     Yang Liu,# Li-Jie Cheng,#Hai-Tao Yue, Wen Che, Jian-Hua Xie*, Qi-Lin Zhou. Divergent Enantioselective Synthesisof Hapalindole-type Alkaloids Using Aatalytic Asymmetric Hydrogenation of a Ketoneto Construct the Chiral Core Structure, Chem. Sci.2016, 7, 4725-4729.

13.    Han Lin, Li-Jun Xiao, Min-Jie Zhou, Hong-Ming Yu,Jian-Hua Xie*, Qi-LinZhou*. Enantioselective Approach to (−)-Hamigeran B and(−)-4-Bromohamigeran B via Catalytic Asymmetric Hydrogenation of Racemic KetoneTo Assemble the Chiral Core Framework, Org. Lett.2016, 18, 1434-1437.

14.     Jian-Hua Xie, Qin-Lin Zhou. Catalytic AsymmetricHydrogenation of Substituted Ketones and Aldehydes via Dynamic KineticResolution: Efficient Approach to Chiral Alcohols, Aldrichimica Acta. 2015,48, 33-40.

15.    Deng-Hui Bao,Hui-Ling Wu, Chao-Lun Liu, Jian-Hua Xie*, Qi-Lin Zhou*, Development of ChiralSpiro P-N-S Ligands for Iridium-Catalyzed Asymmetric Hydrogenation ofβ-Alkyl-β-Ketoesters, Angew.Chem. Int. Ed. 2015,54, 8791-8794.

16.     Wei-Peng Liu, Ming-Lei Yuan, Xiao-Hui Yang, Ke Li,Jian-Hua Xie*, Qi-Lin Zhou*. Efficient Asymmetric Transfer Hydrogenation ofKetones in Ethanol with Chiral Iridium Complexes of SpiroPAP Ligands asCatalysts, Chem. Commun. 2015, 5, 6123-6125.

17.     Xiao-Hui Yang, Ke Wang, Shou-Fei Zhu, Jian-HuaXie*, Qi-Lin Zhou*. Remote Ester Group Leads to Efficient Kinetic Resolution ofRacemic Aliphatic Alcohols via Asymmetric Hydrogenation, J. Am. Chem. Soc. 2014, 136, 17426–17429.

18.     Xiao-Hui Yang, Jian-Hua Xie*, Wei-Peng Liu,Qi-Lin Zhou*, Catalytic Asymmetric Hydrogenation of δ-Ketoesters: HighlyEfficient Approach to Chiral 1,5-Diols, Angew. Chem. Int. Ed. 2013,52, 7833-7836.

19.    Li-Jie Cheng,Jian-Hua Xie*, Yong Chen, Li-Xin Wang, Qi-Lin Zhou*, Enantioselective TotalSynthesis of (-)-Δ8-THC and (-)-Δ9-THC via Catalytic Asymmetric Hydrogenationand SNAr Cyclization, Org. Lett. 2013, 15, 764-767.

20.     Chong Liu, Jian-Hua Xie*, Ya-Li Li, Ji-QiangChen, Qi-Lin Zhou*, Asymmetric Hydrogenation of α,α'-Disubstituted Cycloketonesvia Dynamic Kinetic Resolution: An Efficient Construction of Chiral Diols withThree Contiguous Stereocenters, Angew. Chem. Int. Ed.2013, 52, 593–596.

21.     Qian-Qian Zhang, Jian-Hua Xie*, Xiao-Hui Yang,Jian-Bo Xie, Qi-Lin Zhou*, Iridium-Catalyzed Asymmetric Hydrogenation of α-Substitutedα,β-Unsaturated Acyclic Ketones: Enantioselective Total Synthesis of(-)-Mesembrine, Org. Lett. 2012, 14, 6158–6161.

22.     Jian-Hua Xie*, Lu-ChuanGuo, Xiao-Hui Yang, Li-Xin Wang, Qi-Lin Zhou*, Enantioselective Synthesis of2,6-cis-Disubstituted Tetrahydropyrans via a Tandem Catalytic AsymmetricHydrogenation/Oxa-Michael Cyclization: An Efficient Approach to (-)-Centrolobine, Org. Lett. 2012, 14, 4758–4761.

23.     Ji-Qiang Chen, Jian-Hua Xie*, Deng-Hui Bao, Sheng Liu,Qi-Lin Zhou*, Total Synthesis of(−)-Galanthamine and (−)-Lycoramine via Catalytic Asymmetric Hydrogenation andIntramolecular Reductive Heck Cyclization, Org. Lett., 2012, 14, 2714-2717.

24.     Jian-Hua Xie*, Xiao-Yan Liu, Xiao-Hui Yang,  Jian-Bo Xie, Li-Xin Wang, Qi-Lin Zhou*, ChiralIridium Catalysts Bearing Spiro Pyridine-Aminophosphine Liangds Enable HighlyEfficient Asymmetric Hydrogenation of b-Aryl b-Ketoesters, Angew.Chem. Int. Ed. 2012, 51, 201-203.

25.    Jian-Hua Xie*; Xiao-YanLiu, Jian-Bo Xie, Li-Xin Wang, Qi-Lin Zhou*, An Additional Coordination GroupLeads to Extremely Efficient Chiral Iridium Catalysts for AsymmetricHydrogenation of Ketones, Angew. Chem.Int. Ed. 2011, 50, 7329-7332.

26.    Jian-Bo Xie, Jian-Hua Xie*,Xiao-Yan Liu, Qian-Qian Zhang, Qi-Lin Zhou*, Chiral Iridium SpiroAminophosphine Complexes: Asymmetric Hydrogenation of Simple Ketones,Structure, and Plausible Mechanism, Chem.Asian J. 2011, 6, 899-908.

27.    Jian-Bo Xie, Jian-Hua Xie*, Xiao-Yan Liu,Wei-Ling Kong, Shen Li, and Qi-Lin Zhou*, Highlyenantioselective hydrogenation of a-arylmethylene cycloalkanones catalyzed by iridium complexesof chiral spiro aminophosphine ligands, J.Am. Chem. Soc. 2010, 132, 4538-4539.


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