1. 天津市人类发育与生殖调控重点实验室开放基金，2020XHY02，自拟中药新方对顺铂致卵巢功能早衰的防护作用研究，2020/10-2022/09，10万元，在研，主持

2. 国家自然科学基金面上项目，81973356，精氨酸甲基转移酶-5（PRMT5）调控卵巢癌细胞代谢的作用及干预研究，2020/01-2023/12，55万元，在研，主持  

3. 国家重点研发计划，2018YFC2002000，中国老年人群衰弱的诊断标准及综合干预研究，2018/12-2022/12，在研，项目骨干

4. 高等学校学科创新“111”引智计划 (NO. B16021)（国内主要学术骨干，2016-2020），在研，项目骨干；

5. 广州市科信局（对外研发合作专题），201807010003,靶向代谢酶6PGD克服顺铂耐药的应用研究，2018/04-2020/03，100万元，已结题，主持

6. 广东省科技发展专项资金自然科学基金面上项目，2017A030313890，脂肪酸分解酶HADH调控肺癌细胞能量代谢和增殖的机制研究，2017/05-2020/04，10万元，已结题，主持

1. 天津市自然基金（重点项目），6PGD精氨酸甲基化修饰调控肺癌细胞代谢的作用及机制研究，2021/10-2023/09，在研，主持

2. 天津市人类发育与生殖调控重点实验室开放基金，2020XHY02，自拟中药新方对顺铂致卵巢功能早衰的防护作用研究，2020/10-2022/09，10万元，在研，主持

2. 国家自然科学基金面上项目，81973356，精氨酸甲基转移酶-5（PRMT5）调控卵巢癌细胞代谢的作用及干预研究，2020/01-2023/12，55万元，在研，主持  

3. 国家重点研发计划，2018YFC2002000，中国老年人群衰弱的诊断标准及综合干预研究，2018/12-2022/12，在研，项目骨干

4. 高等学校学科创新“111”引智计划 (NO. B16021)（国内主要学术骨干，2016-2020），在研，项目骨干；

5. 广州市科信局（对外研发合作专题），201807010003,靶向代谢酶6PGD克服顺铂耐药的应用研究，2018/04-2020/03，100万元，已结题，主持

6. 广东省科技发展专项资金自然科学基金面上项目，2017A030313890，脂肪酸分解酶HADH调控肺癌细胞能量代谢和增殖的机制研究，2017/05-2020/04，10万元，已结题，主持

 代表性论文：（*通讯作者#第一作者）

1. Hu X#, Tang X#, Tian X, Lv X, Zhang Y, Pang Y, Deng W, Wang Y, Shan C*, Shang L*. Discovery of indole analogue Tc3 as a potent pyroptosis inducer and identification of its combination strategy against hepatic carcinoma. Theranostics. 2025; 15(4): 1285-1303.

2. Wei Y#, Sun MM#, Zhang RL#, Wang L, Yang LH, Shan CL*, Lin JP*. Discovery of novel dual-target inhibitors of LSD1/EGFR for non-small cell lung cancer therapy. Acta Pharmacol Sin. 2025 Jan 3. doi: 10.1038/s41401-024-01439-w.

3. Zhang W*, Wang J, Shan C*. The eEF1A protein in cancer: Clinical significance, oncogenic mechanisms, and targeted therapeutic strategies. Pharmacol Res. 2024 Jun;204:107195.

4. Zhang H#, Xie F#, Yuan X#, Dai X#, Tian Y, Sun M, Yu S, Cai J, Sun B, Zhang W*, Shan C*. Discovery of a nitroaromatic nannocystin with potent in vivo anticancer activity against colorectal cancer by targeting AKT1. Acta Pharmacol Sin. 2024 May;45(5):1044-1059.

5. Qiao Y, Su M, Zhao H, Liu H, Wang C, Dai X, Liu L, Liu G, Sun H, Sun M, Wang J, Li Z, Fan J, Zhang Q, Li C, Situ F, Xue J, Jia Z*, Zhang C*, Zhang S*, Shan C*. Targeting FTO induces colorectal cancer ferroptotic cell death by decreasing SLC7A11/GPX4 expression. J Exp Clin Cancer Res. 2024 Apr 10;43(1):108.

6. Wang J*, Chang H, Quan X, Dai X, Wang Y, Wang C, Zhang S*, Shan C*. A model for identification of potential phase-separated proteins based on protein sequence, structure and cellular distribution. Int J Biol Macromol. 2023 Jun 5:125196.

7. Xie F#, Zhang H#, Zhu K#, Jiang CS#, Zhang X, Chang H, Qiao Y, Sun M, Wang J, Wang M, Tan J, Wang T, Zhao L, Zhang Y, Lin J, Zhang C, Liu S, Zhao J*, Luo C*, Zhang S*, Shan C*. PRMT5 promotes ovarian cancer growth through enhancing Warburg effect by methylating ENO1. MedComm (2020). 2023 Mar 28;4(2):e245.

8. Sun M#, Li L#, Niu Y#, Wang Y, Yan Q, Xie F, Qiao Y, Song J, Sun H, Li Z, Lai S, Chang H, Zhang H, Wang J, Yang C, Zhao H, Tan J, Li Y, Liu S, Lu B, Liu M, Kong G, Zhao Y, Zhang C, Lin SH*, Luo C*, Zhang S*, Shan C*. PRMT6 promotes tumorigenicity and cisplatin response of lung cancer through triggering 6PGD/ENO1 mediated cell metabolism. Acta Pharm Sin B. 2023 Jan;13(1):157-173. (高被引论文)

9. Wang J, Qiao Y, Sun M, Sun H, Xie F, Chang H, Wang Y, Song J, Lai S, Yang C, Li X, Liu S, Zhao X, Ni K, Meng K, Zhang S*, Shan C*, Zhang C*, FTO promotes colorectal cancer progression and chemotherapy resistance via demethylating G6PD/PARP1.Clinical and Translational Medicine.2022 Mar;12(3):e772.

10. Sun M#, Sheng H#, Wu T#, Song J, Sun H, Wang Y, Wang J, Li Z, Zhao H, Tan J, Li Y, Chen G, Huang Q, Zhang Y, Lan B, Liu S*, Shan C*, Zhang S*. PIKE-A promotes glioblastoma growth by driving PPP flux through increasing G6PD expression mediated by phosphorylation of STAT3. Biochem Pharmacol. 2021 Oct;192:114736.

11. Feng Q, Li X, Sun W, Sun M, Li Z, Sheng H, Xie F, Zhang S*, Shan C*. Targeting G6PD reverses paclitaxel resistance in ovarian cancer by suppressing GSTP1. Biochem Pharmacol. 2020 Aug;178:114092.

12. Sheng H, Li Z, Su S, Sun W, Zhang X, Li L, Li J, Liu S, Lu B, Zhang S*, Shan C*. YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translation. Carcinogenesis. 2020 Jul 10;41(5):541-550.2 (高被引论文).

13. Li Y#, Liang R#, Sun M#, Li Z, Sheng H, Wang J, Xu P, Liu S, Yang W, Lu B, Zhang S*, Shan C*. AMPK-dependent phosphorylation of HDAC8 triggers PGM1 expression to promote lung cancer cell survival under glucose starvation. Cancer Lett. 2020 May 28;478:82-92.2.

14. Shan C*,#, Lu Z#, Li Z#, Sheng H, Fan J, Qi Q, Liu S, Zhang S*. 4-hydroxyphenylpyruvate dioxygenase promotes lung cancer growth via pentose phosphate pathway (PPP) flux mediated by LKB1-AMPK/HDAC10/G6PD axis. Cell Death Dis. 2019 Jul 8;10(7):525.

15. Zhang S, Sheng H, Zhang X, Qi Q, Chan CB, Li L, Shan C*, Ye K*. Cellular energy stress induces AMPK-mediated regulation of glioblastoma cell proliferation by PIKE-A phosphorylation. Cell Death Dis. 2019 Mar 4;10(3):222.

16. Wang J#, Luo C#, Shan C#, You Q#, Lu J, Elf S, Zhou Y, Wen Y, Vinkenborg JL, Fan J, Kang H, Lin R, Han D, Xie Y, Karpus J, Chen S, Ouyang S, Luan C, Zhang N, Ding H, Merkx M, Liu H, Chen J*, Jiang H*, He C*. Inhibition of human copper trafficking by a small molecule significantly attenuates cancer cell proliferation. Nat Chem. 2015 Dec;7(12):968-79.

17. Lin R#, Elf S#, Shan C#, Kang HB, Ji Q, Zhou L, Hitosugi T, Zhang L, Zhang S, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, Mitsche M, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Hurwitz SJ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Lei Q, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J*, Chen J*. 6-Phosphogluconate dehydrogenase links oxidative PPP, lipogenesis and tumour growth by inhibiting LKB1-AMPK signalling. Nat Cell Biol. 2015 Nov;17(11):1484-96.

18. Shan C#, Elf S#, Ji Q, Kang HB, Zhou L, Hitosugi T, Jin L, Lin R, Zhang L, Seo JH, Xie J, Tucker M, Gu TL, Sudderth J, Jiang L, DeBerardinis RJ, Wu S, Li Y, Mao H, Chen PR, Wang D, Chen GZ, Lonial S, Arellano ML, Khoury HJ, Khuri FR, Lee BH, Brat DJ, Ye K, Boggon TJ, He C, Kang S, Fan J*, Chen J*. Lysine acetylation activates 6-phosphogluconate dehydrogenase to promote tumor growth. Mol Cell. 2014 Aug 21;55(4):552-65.

19. Shan C, Kang HB, Elf S, Xie J, Gu TL, Aguiar M, Lonning S, Hitosugi T, Chung TW, Arellano M, Khoury HJ, Shin DM, Khuri FR, Boggon TJ, Fan J*. Tyr-94 phosphorylation inhibits pyruvate dehydrogenase phosphatase 1 and promotes tumor growth. J Biol Chem. 2014 Aug 1;289(31):21413- 22.

20. Fan J#, Shan C#, Kang HB#, Elf S, Xie J, Tucker M, Gu TL, Aguiar M, Lonning S, Chen H, Mohammadi M, Britton LM, Garcia BA, Alečković M, Kang Y, Kaluz S, Devi N, Van Meir EG, Hitosugi T, Seo JH, Lonial S, Gaddh M, Arellano M, Khoury HJ, Khuri FR, Boggon TJ, Kang S*, Chen J*. Tyr phosphorylation of PDP1 toggles recruitment between ACAT1 and SIRT3 to regulate the pyruvate dehydrogenase complex. Mol Cell. 2014 Feb 20;53(4):534-48.

21. Shan C#, Zhang S, Cui W, You X, Kong G, Du Y, Qiu L, Ye L*, Zhang X*. Hepatitis B virus X protein activates CD59 involving DNA binding and let-7i in protection of hepatoma and hepatic cellsfrom complement attack. Carcinogenesis. 2011, 32(8):1190-7.

22. Shan C#, Xu F. Zhang S, You J, You X, Qiu L, Zheng J, Ye L*, Zhang X*. Hepatitis B virus X protein promotes livercell proliferation via a positive cascade loop involving arachidonic acidmetabolism and p-ERK1/2. Cell Res. 2010, 20(5):563-75.