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个人概况:
天津市“131”创新型人才培养工程第三层次人选,天津市“项目+团队”重点培养专项入选团队(创新类C级)负责人。中国生物材料学会生物材料生物学评价分会委员。郑州大学生物工程系学士,南开大学生物化学与分子生物学硕士和博士。2013年进入南开大学生物活性材料教育部重点实验室工作,一直从事小口径人工血管的研究,着力于通过血管材料的结构设计、功能修饰与降解调控来提高小口径血管材料的通畅性与组织再生性。获得国家授权发明专利5项;申请国家发明专利9项。作为项目负责人主持包括国自然面上项目和天津市自然科学基金重点项目在内的科研项目7项、主持横向项目3项。以第一作者或通讯作者在本领域权威期刊AdvancedSciences、Biomaterials、NatureCommunications、NanoLetters、Arteriosclerosis、ThrombosisandVascular Biology、AcsApplied Materials&Interfaces、AdvancedHealthcare Materials等杂志发表SCI论文20篇;参编外文专著3部,中文专著1部;一项人工血管研究成果正在进行产业转化。
研究方向:
1.生物活性人工血管的构建;
2.干细胞治疗心血管疾病。
招生方向:生物材料与组织工程
主持纵向项目:
1. 天津市人力资源和社会保障局,天津市“项目+团队”重点培养专项入选团队(创新类C级), 同种异体血管性能优化研究,2020/12-2023/12,20万,在研,主持。
2.血管稳态与重构的调控机制重大研究计划培育项目,91939112,仿生电信号血管材料调控血管组织再生与功能稳态的作用研究,2020/01-2021.12,40万,在研,主持。
3.天津市自然科学基金重点项目,18JCZDJC37600,聚合物纤维骨架增强型体内工程化小口径人工血管的构建与功能修饰,2018/04-2021/03,20万,在研,主持。
4.国家自然科学基金面上项目,81772000,聚合物熔融纺丝纤维与脱细胞基质构成的杂化人工血管材料的构建与功能修饰研究,2018/01-2021/12,55万元,在研,主持。
5.国家自然科学基金青年科学基金在研,主持。项目,81401534,生物活性人工血管体内降解及血管再生调控,2015/01-2017/12,23万元,结题,主持。
6.天津市应用基础与前沿技术研究计划(青年项目),14JCQNJC13900,结构设计及功能修饰构建新型小口径人工血管,2014/04-2017/03,6万,结题,主持。
7.中国博士后科学基金项目,2014M561177,可诱导平滑肌细胞取向再生的小口径人工血管的研究,2014.09-2016.09,5万,结题,主持。
主持横向项目:
1. 可缓释一氧化氮的血液接触材料表面功能构建,2020/01-2021/12,15万,主持
2.电纺活性人工血管的体内植入评价,2019/12-2020/06,2.2万,主持。
3.新型体内工程化血管的生物医学评价,2019.04-2022/04,50万,主持
主持纵向项目:
1. 天津市人力资源和社会保障局,天津市“项目+团队”重点培养专项入选团队(创新类C级), 同种异体血管性能优化研究,2020/12-2023/12,20万,在研,主持。
2.血管稳态与重构的调控机制重大研究计划培育项目,91939112,仿生电信号血管材料调控血管组织再生与功能稳态的作用研究,2020/01-2021.12,40万,在研,主持。
3.天津市自然科学基金重点项目,18JCZDJC37600,聚合物纤维骨架增强型体内工程化小口径人工血管的构建与功能修饰,2018/04-2021/03,20万,在研,主持。
4.国家自然科学基金面上项目,81772000,聚合物熔融纺丝纤维与脱细胞基质构成的杂化人工血管材料的构建与功能修饰研究,2018/01-2021/12,55万元,在研,主持。
5.国家自然科学基金青年科学基金在研,主持。项目,81401534,生物活性人工血管体内降解及血管再生调控,2015/01-2017/12,23万元,结题,主持。
6.天津市应用基础与前沿技术研究计划(青年项目),14JCQNJC13900,结构设计及功能修饰构建新型小口径人工血管,2014/04-2017/03,6万,结题,主持。
7.中国博士后科学基金项目,2014M561177,可诱导平滑肌细胞取向再生的小口径人工血管的研究,2014.09-2016.09,5万,结题,主持。
主持横向项目:
1. 可缓释一氧化氮的血液接触材料表面功能构建,2020/01-2021/12,15万,主持
2.电纺活性人工血管的体内植入评价,2019/12-2020/06,2.2万,主持。
3.新型体内工程化血管的生物医学评价,2019.04-2022/04,50万,主持
第一或通讯作者文章
(1) Jiaying Zhou#, Meiyu Wang#, Tingting Wei#,Lingchuang Bai, Jing Zhao, Kai Wang*, and Yakai Feng*. EndothelialCell-Mediated Gene Delivery for In Situ Accelerated Endothelialization of aVascular Graft. ACS Applied Materials&Interfaces. 2021.13(14): 16097-16105.出版日期 2021.04.14. Published. DOI: 10.1021/acsami.1c01869 91939112标注
(2) Muhammad Rafique#, Tingting Wei#, Qiqi Sun, AdamC. Midgley, Ziqi Huang, Ting Wang, Muhammad Shafiq, Dengke Zhi, Jianghua Si, HongyuYan, Deling Kong, Kai Wang*. Theeffect of hypoxia-mimicking responses on improving the regeneration ofartificial vascular grafts. Biomaterials. 2021, 271: 120746. DOI:10.1016/j.biomaterials.2021.120746 81772000 91939112标注。
(3) Hongyu Yan#, Xingyan Mi#, Adam C. Midgley, Xinchen Du, ZiqiHuang, Tingting Wei, Ruihua Liu, Tengzhi Ma, Dengke Zhi, Dashuai Zhu, TingWang, Guowei Feng, Ying Zhao, Weiye Zhang, Ju He, Meifeng Zhu*, Deling Kong*,and Kai Wang*. Targeted Repair ofVascular Injury by Adipose-derived Stem Cells Modified with P-selectin BindingPeptide. Advanced Science. 2020.7(11):1903516-38. 2020 Apr 22. doi: 10.1002/advs.201903516 81772000
(4) Meiling Wen, Dengke Zhi, Lina Wang,Ce Cui, Ziqi Huang, Yunhui Zhao, KaiWang*, Deling Kong, Xiaoyan Yuan*. Local Delivery ofDual miRNAs in Trilayered Electrospun Grafts for Vascular Regeneration. ACS Applied Materials &Interfaces, 2020, 12 (6):6863-6875. EI收录 SCI收录 2020, jan,20. doi: 10.1021/acsami.9b19452 81772000
(5) Meifeng Zhu, Wen Li, Xianhao Dong,Xingyu Yuan, Adam C. Midgley, Hong Chang, Yuhao Wang, Haoyu Wang, Kai Wang*, Peter X Ma3,Hongjun Wang*, Deling Kong*. In vivo engineered extracellular matrix scaffolds with instructiveniches for oriented tissue regeneration. Nature Communications. 2019, 10(1) :4620-4631.Oct 11. doi: 10.1038/s41467-019-12545-3. 81772000
(6) 吴依璠#,智登科#, Adam C. Midgley, 赵强, 孔德领*, 王恺*. 人工血管组织再生的细胞来源. 中国科学: 生命科学, 2019, 49(9): 1100-1108。.Wu Y F, Zhi D K, Adam C M, et al. The cell source in tissue regeneration ofvascular grafts (in Chinese). Sci Sin Vitae, 2019, 49, doi: 10.1360/SSV-2019-0156. 2019.SEP.17.
(7) Yuna Shang#,Dengke Zhi#, Guowei Feng, Zhongyan Wang, Duo Mao, Shuang Guo, RuihuaLiu, Lulu Liu, Shuhao Zhang, Shenghuan Sun, Kai Wang*, Deling Kong, Jie Gao* ,Zhimou Yang*.Supramolecular Nanofiberswith Superior Bioactivity to Insulin-Like Growth Factor‐I. NanoLetters. 2019,19(3): 1560-1569. MAR 13. DOI: 10.1021/acs.nanolett.8b04406. EI收录 SCI收录
(8) Xin Zhou#, Yiwa Pan#, Ruihua Liu, Xin Luo, Xianyan Zeng, Dengke Zhi, JingLi, Quhan Cheng, Ziqi Huang, Hui Zhang*, Kai Wang*. Biocompatibility and biodegradationproperties of polycaprolactone/polydioxanonecomposite scaffolds prepared by blend or co-electrospinning. Journal of Bioactive and Compatible Polymers. 2019, 34(2) 115-130. 2019 March.19. DOI: 10.1177/0883911519835569 EI收录 SCI收录
(9) Qingying Shi, Xin Luo, Ziqi Huang, Adam C. Midgley, Bo Wang, Ruihua Liu, DengkeZhi,Tingting Wei, Xin Zhou, Mingqiang Qiao, Jun Zhang*, Deling Kong*, Kai Wang*. Cobalt-mediated multi-functional dressingspromote bacteria-infected wound healing. ActaBiomaterialia, 2019, 86: 465-479. SCI收录 2019.03.01
(10)Muhammad Shafiq, Qiuying Zhang, Dengke Zhi, Kai Wang*,Deling Kong, Dong-Hwee Kim*. In Situ BloodVessel Regeneration Using SP (Substance P) and SDF (Stromal Cell–Derived Factor)-1α Peptide Eluting Vascular Grafts. ArteriosclerThromb Vasc Biol, 2018,38(7):e117-e134.SCI收录 2018 May 31
(11) Kang Qin, Yifan Wu, YiwaPan, Kai Wang*, Deling Kong, QiangZhao*. Implantation of Electrospun Vascular Grafts with OptimizedStructure in a Rat Model. Journal of Visualized Experiments,2018,136:e57340. SCI收录2018 Jun 27
(12)WenLi, JingruiChen, PanXu, Meifeng Zhu*, Yifan Wu, Zhihong Wang, Tiechan Zhao,Quhan Cheng, KaiWang*, Guanwei Fan, Yan Zhu, Deling Kong, Long-term evaluation of vascular grafts withcircumferentially aligned microfibers in a rat abdominal aorta replacementmodel. Journalof Biomedical Materials Research Part B: Applied Biomaterials, 2018,106(7):2596-2604. EI收录 SCI收录 2018 Feb7
(13)YiwaPan#, Xin Zhou#, Yongzhen Wei,Qiuying Zhang, Ting Wang, Meifeng Zhu, Wen Li, Rui Huang, Ruming Liu, JingruiChen, Guanwei Fan, Kai Wang*, DelingKong, Qiang Zhao*, Small-diameterhybrid vascular grafts composed of polycaprolactone and polydioxanone fibers.ScientificReports, 2017, 7: 3615-3626. SCI收录 2017.Jun 15
(14)ZhihongWang#, Yifan Wu#, Jianing Wang, Chuangnian Zhang, HongyuYan, Meifeng Zhu, Kai Wang*, ChenLi, Qingbo Xu, Deling Kong*, Effect of resveratrol on modulation of endothelialcells and macrophages for rapid vascular regeneration from electrospun poly (ε-caprolactone) scaffolds, ACS Applied Materials&Interfaces, 2017, 9 (23):19541-19551. EI收录 SCI收录 2017.Jun.14
(15) KaiWang#, Qiuying Zhang#,LiqiangZhao, Yiwa Pan, Ting Wang, Dengke Zhi, Shaoyang Ma, Peixin Zhang, Tiechan Zhao,Siming Zhang, Wen Li, Meifeng Zhu, Yan Zhu, Zhang Jun*, Mingqiang Qiao*, DelingKong*, FunctionalModification of Electrospun PCL Vascular Grafts with the Fusion Protein VEGF-HGFIEnhanced Vascular Regeneration, ACSApplied Materials & Interfaces, 2017, 9(13): 11415-11427. EI收录 SCI收录2017.Apr.5
(16)LeiZhu#, Kai Wang#,Teng Ma#,Liangliang Huang#, Bing Xia, Shu Zhu, Yafeng Yang, Zhongyang Liu,Xin Quan, Kai Luo, Deling Kong*, Jinghui Huang*, Zhuojing Luo*, Noncovalent Bonding of RGD and YIGSR to an ElectrospunPoly(ε-caprolactone) Conduit through Peptide Self-Assembly toSynergistically Promote Sciatic Nerve Regeneration in Rats,Advanced Healthcare Materials, 2017, 2017, 6 (8): 1600860. SCI收录 2017. Jan 31
(17)LiqiangZhao#, Shaoyang Ma#, YiwaPan, Qiuying Zhang, Kai Wang*, DongminSong, Xiangxiang Wang, Guowei Feng, Ruming Liu, Haijin Xu, Jun Zhang, MingqiangQiao*, Deling Kong, FunctionalModification of Fibrous PCL Scaffolds with Fusion Protein VEGF-HGFI EnhancedCellularization and Vascularization, Advanced Healthcare Materials, 2016, 5(18):2376-2385SCI收录2016.09.21
(18) KaiWang#, Wenting Zheng#, Yiwa Pan, Shaoyang Ma, Yong Guan, Ruming Liu, MeifengZhu, Xin Zhou, Jun Zhang, Qiang Zhao, Yan Zhu*, Lianyong Wang*, Deling Kong,Three-layered PCL Grafts Promoted Vascular Regeneration in a Rabbit CarotidArtery Model, MacromolecularBioscience, 2016, 16(4): 608-618. EI收录 SCI收录 2016.01.12
(19)HuaiminWang#, Duo Mao#, YouzhiWang, Kai Wang*, Xiaoyong Yi, DelingKong, Zhimou Yang, Qian Liu*, Dan Ding*. Biocompatible fluorescent supramolecularnanofibrous hydrogel for long-term cell tracking and tumor imaging applications.Scientific Reports. 2015, 5:16680. SCI收录
(20)JunAn#, Kai Wang#,Siyuan Chen, Meimei Kong, Yuxin Teng, Lianyong Wang, CunjiangSong, Deling Kong and Shufang Wang*. Biodegradability,cellular compatibility and cell infiltration ofpoly(3-hydroxybutyrate-co-4-hydroxybutyrate) in comparison with poly(ε-caprolactone) and poly(lactide-co-glycolide).Journal of Bioactive and Compatible Polymers. 2015, 30(2): 209-221. EI收录 SCI收录
(21)Kai Wang, Xuejiao Chen, Yiwa Pan,Yun Cui, Xin Zhou, Deling Kong, Qiang Zhao*, EnhancedVascularization in Hybrid PCL/Gelatin Fibrous Scaffolds with Sustained Releaseof VEGF. BiomedResearch International,2015, 2015: 865076-865086 SCI收录
(22) KaiWang#,Meifeng Zhu#, Ting Li,Wenting Zheng, Li Li, Mian Xu, Qiang Zhao, Deling Kong*, Lianyong Wang*,Improvement of Cell Infiltration in Electrospun Polycaprolactone Scaffolds forthe Construction of Vascular Grafts, Journal of Biomedical Nanotechnology,2014, 10(8): 1588-1598 EI收录 SCI收录
(23) KaiWang#, Meng Xu#, Meifeng Zhu, Hong Su, Hongjun Wang*,Deling Kong, Lianyong Wang*, Creation of Macropores in Electrospun Silk FibroinScaffolds Using Sacrificial PEO-microparticles to Enhance Cellular Infiltration,Journal ofBiomedical Materials Research Part A, 2013, 101(12):3474-3481
(24) Kai Wang, Yong Guan, Yi Liu, Meifeng Zhu, Ting Li, DiAn, Lailiang Ou*, Yongzhe Che, Guorong Zhang, Jun Zhang*, Xi-Long Zheng, DelingKong. Fibrin Glue with Autogenic Bone Marrow Mesenchymal Stem Cells forUrethral Injury Repair in Rabbit Model. Tissue Engineering: Part A. 2012,18(23-24):2507-2517.
(25) MinZhang#, Kai Wang#, Zhexiang Wang,Bin Xing, Qiang Zhao*, Deling Kong*. Small-diameter tissue engineeredvascular graft made of electrospun PCL/lecithin blend. Journal ofMaterials Science - Materials in Medicine. 2012, 23(11): 2639-2648.
(26) 王 恺,马绍扬,张 钧. 利用装载内皮细胞生长因子的丝素纳米球制备具有生物活性的电纺支架材料. 南 开 大 学 学 报(自然科学版).2019, 49(6):1-6. 文章编号:0465-7942(2016)06-0001-06. 收稿日期:2016-01-15。
学术奖励:
1. 王恺(8/11),生物活性材料在治疗缺血性疾病中的促血管再生作用,天津市科学技术委员会,自然科学,省部一等奖,2019。
(孔德领、赵强、李宗金、杨志谋、丁丹、杨军、王淑芳、王恺、王玲、沈杰、张钧)
2.王恺(5/8),真菌疏水蛋白自组装分子机制和材料表面修饰功能的研究,天津市科学技术委员会,自然科学,省部二等奖,2018。
(乔明强、徐海津、王泽方、赵立强、王恺、孔德领、于雷、张钧)
3. 2018年8月,第十次全国归侨侨眷代表大会在北京召开,“心血管组织工程团队”荣获“全国侨联系统先进组织”荣誉称号。团队主要成员包括孔德领、王淑芳、杨志谋、王连永、欧来良、赵强、丁丹、王恺、张钧、高洁等。
著作:
1. 书籍名称:Tissue-Engineered Vascular Grafts;出版社: Springer-Verlag(施普林格);出版年份:2020; 书号ISBN:978-3-030-05335-2 (eBook); 章节:The Incorporation and Release of Bioactive Molecules in Vascular Grafts 这一章节第4 完成人;
2.书籍名称:Polymeric Biomaterials for Tissue Regeneration- From Surface/Interface Designto 3D Constructs;出版社: Springer-Verlag(施普林格);出版年份:2016; 书号ISBN:978-981-10-2292-0; ISBN 978-981-10-2293-7 (eBook); 章节(11):Regeneration of Blood Vessels 这一章节的第1完成人;
授权专利
1. 王恺;孔德领;师庆英;张钧;罗鑫;智登科。离子介导敷料及其制备方法和应用,发明专利。申请号:201810378479.0,申请日期: 2018.04.25。授权公布号:CN106075596B;授权日期:2021.05.11。
2. 朱美峰,孔德领,王恺,董显豪。一种三层人工血管制备技术,发明专利,申请号:201610589001.3。申请日期,2016.07.21;授权公布号:CN106075596B;授权日期:2021.02.09。
3. 王婷,赵静波,毛洪钧,王恺。PM2.5的模型颗粒物的制备方法和模型颗粒物,发明专利,申请号:201910087764.1。申请日期,2019-01-29;授权公布号:CN109655384B;授权日期,2020-10-20。公开日期2019-04-19
4. 王连永;朱美峰;孔德领;王志红;王恺;王淑芳。中国发明专利。专利名称:一种双层结构人工血管的制备方法。授权号:ZL201510167670.7. 申请日期,2015.04.10, 授权公告日:2017.03.29
5. 王婷;孙红文;王恺;毛洪钧。中国发明专利。专利名称:一种检测土壤外源微生物数量的示踪计数方法。授权号:ZL201610178528.7. 申请日期 2016.03.25,授权公告日:2019.03.05
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