1. 国家自然科学基金面上项目，22077068，基于肝素的小分子药物治疗脓毒症的应用研究，主持

2. 科技部重点研发计划，2018YFA0507204, 高致病性病毒转录复制过程关键蛋白质机器的干预策略，主持

3.天津市科委重点项目，17JCZDJC32800 ，新型肝素类抗血栓药物的合成及成药性评价，主持

4.国家自然科学基金面上项目，21572105，糖肽疫苗的合成与免疫学评价，主持

5.天津市科技支撑重点项目，13ZCZDSY00600，化学多糖类药物--磺达肝癸钠五糖的大规模制备技术，主持

46，Danyang Wang, Yonghui Liu*, WeiZhao*, “The adjuvant effects on vaccine and theimmunomodulatory mechanisms of polysaccharides from traditional Chinese medicine” , Front. Mol. Biosci., 2021, https://doi.org/10.3389/fmolb.2021.655570.

45.  YonghuiLiu, Mingjing Li, Haomiao Zhu, Zhe Jing, Xiaona Yin,Kun Wang, Zhangyong Hong*, Wei Zhao*, “Alum colloid encapsulated inside β-glucan particles enhancehumoral and CTL immune responses of MUC1 vaccine”, Chinese Chemical Letters. 2021:https://doi.org/10.1016/j.cclet.2021.01.035.

44.  Zhaoyu Wang, Qiang Chen,Haomiao Zhu, Xiaona Yin, Kun Wang, Yonghui Liu*, Wei Zhao*, “Enhancing the immune response and tumorsuppression effect of antitumor vaccines adjuvanted with non-nucleotide smallmolecule STING agonist”, Chinese ChemicalLetters. 2021: https://doi.org/10.1016/j.cclet.2021.01.036.

43.  Yonghui Liu, Zhaoyu Wang, Fan Yu, Mingjing Li, HaomiaoZhu, Kun Wang, Meng Meng*, Wei Zhao*,“The Adjuvant of α-Galactosylceramide Presented by Gold Nanoparticles EnhancesAntitumor Immune Responses of MUC1 Antigen-Based Tumor Vaccines ”, International Journal of Nanomedicine. 2021:16 403–420.

42． Shuo Wang, Zengyi Liu, Yue Tong, Yunqian Zhai, XiujieZhao, Xinmin Yue, Yanqi Qiao, Yonghui Liu, Yongmei Yin, Rimo Xi, Wei Zhao*, Meng Meng*, “Improved cancer phototheranostic efficacy of hydrophobic IR780 via parenteralroute by association with tetrahedral nanostructured DNA ”, Journal of Controlled Release. 2021, 330, 483-492.

41． Yonghui Liu, Bocheng Yan, Zhaoyu Wang, Haomiao Zhu, Xiaona Yin, KunWang, Menglei Wang, and WeiZhao*,“Design, Synthesis, and Preliminary Immunological Studiesof MUC1-Based Antitumor Vaccines Adjuvanted with R- and S‑FSL‑1”， ACS Med. Chem. Lett. 2020, 11,7, 1371-1376.

40.  Mingjing Li, Zhaoyu Wang, Bocheng Yan, Xiaona Yin,Yue Zhao, Fan Yu, Meng Meng, Yonghui Liu* and Wei Zhao*, “Designof a MUC1-based tricomponent vaccine adjuvanted with FSL-1 for cancerimmunotherapy”， Med. Chem. Commun, 2019, 10, 2073-2077.

39.  Hongzhen Jin, Qiang Chen, Yan-Yan Zhang,Kai-Feng Hao, Guo-Qiang Zhang* and Wei Zhao*, “Preactivation-Based, IterativeOne-Pot Synthesis of Anticoagulant Pentasaccharide Fondaparinux Sodium”， Organic Chemistry Frontiers, 2019, 6, 3116-3120.

38.  FanYu, Song Guo, Te Li, Jie Ran, Wei Zhao, Dengwen Li, Min Liu, Xiumin Yan, Xiaoyong Yang, XueliangZhu, Jun Zhou*, “Ciliary defects caused by dysregulation of O-GlcNAc modification are associated with diabeticcomplications” , Cell Research, 2019,209 (2), 171-173.

37.  Mingjing Li, FanYu, Chao Yao, Peng George Wang, Yonghui Liu*and Wei Zhao*, “Syntheticand immunological studies on trimeric MUC1 immunodominant motif antigen-basedanti-cancer vaccine candidates”, Organic & Biomolecular Chemistry, 2018, 16, 993 – 999.

36.  Yonghui Liu,Youzhi Wang, FanYu, Zhenqing Zhang,Zhimou Yang, Wenpeng Zhang,* PengGeorge Wang and Wei Zhao *, “Potentiating the immune response ofMUC1-based antitumor vaccines using a peptide-based nanovector as a promisingvaccine adjuvant”. ChemicalCommunications,2017, 53, 9486-9489.

35. Guoqiang Zhang, Hongzhen Jin,Yunyan Zhao, Lina Guo, Xue Gao, Xiaoxue Wang, Shiyang Tie, Jie Shen, PengGeorge Wang, Hao Gan, * Huifei Cui, * Wei Zhao*, An efficient anticoagulantcandidate: Characterization, synthesis and invivo study of a fondaparinux analogue Rrt1.17, European Journal of Medicinal Chemistry, 2017, 126,1039-1055.

34.  Yonghui Liu, Wenpeng Zhang, Qianqian He, Fan Yu, Tianbang Song, TingtingLiu, Zhenqing Zhang, Jun Zhou, Peng George Wang* and Wei Zhao*, “Fully synthetic self-adjuvanting MUC1-fibroblaststimulating lipopeptide 1 conjugates as potential cancer vaccines”. Chemical Communications, 2016, 52, 10886 - 10889.

33. WuZhigang , Zhao Guohui, Li Tiehai, Qu Jingyao, Guan Wanyi,Wang Jiajia, Ma Cheng, Li Xu, ZhaoWei, Wang Peng G.”Biochemical characterization of an alpha 1,2-colitosyltransferase from Escherichia coli O55:H7”. Glycobiology, 2016, 26: 493-500.

32.  Yonghui Liu, Tianbang Song, Weijia Meng, Yun Xu, Peng George Wang,Wei Zhao*,“Hafnium(IV)triflate as a highly efficient catalyst for Ferrier rearrangement of O- andS-nucleophiles with glycals”, Tetrahedron Letters. 2016, 25，2758–2762.

31.  Jiajia Wang, Xiaomin Wang, Yunyan Zhao,Xiaoyao Ma, Yue Wan, Zhongwei Chen, Hao Chen, Hao Gan, Jing Li, Lei Li, PengGeorge Wang and Wei Zhao*, “Synthesisand biological evaluation of D-gluconhydroximo-1,5-lactam and itsoxime-substituted derivatives as pharmacological chaperones for the treatmentof Gaucher disease”, Med.Chem. Commun, 2016, 7, 365.

30. Lei Li, YonghuiLiu, Tiehai Li, Wenjun Wang, Zaikuan Yu, Cheng Ma, JingyaoQu, Wei Zhao, XiChen and Peng G. Wang*, “Efficient chemoenzymaticsynthesis of novel galacto-N-biose derivatives and their sialylated forms”, Chem. Commun, 2015,51, 10310-10313.

29. WenjunWang, Zhongyue Yang, Yun Xu, Taibao Liu, Tianbang Song, Yunyan Zhao,Xiufang Xu*, Wei Zhao* andPeng George Wang*,““Armed and disarmed” theory in the addition of an azide radical toglucals”, RSC Advances, 2015, 5, 38577 - 38580.

28. YunXu, Wenjun Wang, Yu Cai, Xia Yang,
Peng George Wang and Wei Zhao*, “A convenient andefficient synthesis of glycals by
zinc nanoparticles”, RSCAdvances, 2014, 4 , 46662 - 46665.

27. LinaGuo, Taibao Liu,Kai Chen,Tianbang Song, Peng George Wang* and Wei Zhao*,“Facile synthesis of 5-hydroxy-L-lysine from D-galactose as achiral-precursor”, Organic &
 Biomolecular Chemistry, 2014, 12,7310–7317.

26. Tiehai Li, Hui Ye, XuefengCao, Jiajia Wang, Yonghui Liu, Lifei Zhou, Qiang Liu, Wenjun Wang, Jie Shen^*, Wei Zhao^*, and Peng Wang^*, “TotalSynthesis of Anticoagulant Pentasaccharide Fondaparinux”. ChemMedChem 2014, 9, 1071 – 1080.

25. Zhonghua Li, Tiehai Li, Shaoxing Dai, Xiaoli Xie,Xiaofeng Ma, Wei Zhao, Weimin Zhang, Jing Li^* and Peng George Wang^*,“New Insights into the Pharmacological Chaperone Activity of C2-SubstitutedGlucoimidazoles for the Treatment of Gaucher Disease”. ChemBioChem. 2013, 14, 1239-1247.

24. Lei Li, Yonghui Liu, Yue Wan, Yanhong Li, Xi Chen, Wei Zhao^*, and Peng George Wang^*,“Efficient EnzymaticSynthesis of Guanosine 5’-diphosphate-Sugars and Derivatives”. Organic letters.2013, 21, 5528–5530.

23. Lina Guo, Yonghui Liu, Yue Wan, PengGeorge Wang and Wei Zhao*,“Effectiveand one-step stereo-controlled synthesis of polybenzyloxylateddiiodopentanesfor the synthesis of five-membered imino-sugars”. Tetrahedron Letters. 2013, 54，2579-2582.

22. Tiehai Li,Zhonghua Li, Jing Li, Jiajia Wang, Lina Guo, Peng George Wang^*, Wei Zhao*, “Elevationof cellular O-GlcNAcylation level by a potent and selective O-GlcNAcaseinhibitor based on tetrahydroimidazopyridine scaffold.” Bioorganic & MedicinalChemistry Letters. 22 (2012) 6854-6857.

21.Lei Li, Yonghui Liu, Wenjun Wang, Jiansong Cheng, Wei Zhao*,and Peng Wang*. “A Highly Efficient Galactokinase from Bifidobacterium infantis with Broad Substrate Specificity.” Carbohydrate Research, 2012,355C, 34-38.

20. Jing Li,Zhonghua Li, Tiehai Li, Lin Lin, Yan Zhang, Lina Guo, Yan Xu, Wei Zhao*, and Peng Wang^*, “Identification of aSpecific Inhibitor of nOGA-a Caspase-3 Cleaved O-GlcNAcase Variant duringApoptosis.” Biochemistry (Moscow), 2012,Vol. 77, No. 2, 240-247.

19. Lina Guo, Yue Wan, Xin Wang, Peng George Wang, Wei Zhao*, “Development of Aminoglycoside Antibiotics by Carbohydrate Chemistry.”Mini-Reviews in MedicinalChemistry. 2012, 12, 1533-1541. 

18. Zhenxing Zhang, Wei Zhao,Bin Wang, Chengfeng Xia, Wenpeng Zhang, and Peng George Wang^*,“The totalsynthesis of immunostimulant a-Galactosylceramides from naturally configuredr-Galactoside raffinose.” Organicletters. 2011, 17, 4530-4533.

17. Zhen-Xing Zhang,Baolin Wu, Bin Wang, Tie-Hai Li, Peng-Fei Zhang, Li-Na Guo, Wen-jun Wang, Wei Zhao, Peng George Wang^*, “Facile andstereo-controlled synthesis of 2-deoxynojirimycin, Miglustat and Miglitol.” TetrahedronLetters. 29 (2011). 3802-3804.

16. Wenjun Wang,ChenJin, Lina Guo, Yu Liu, Yue Wan, Xin Wang*,Lei Li*, WeiZhao*, and Peng George Wang, “Preparationof oligosaccharides by homogenous enzymatic synthesis and solid phaseextraction.”Chemical Communications, 2011, 47, 11240-11242. 

15. Wenjun Wang, Lei Li, Chen Jin, Yujie Niu, Sen Li, JiMa, Linfeng Li, Yu Liu, Li Cai, Wei Zhao*, Peng George Wang^*,“Enzymatic synthesis of a 6-sialyl lactose analogue using apH-responsive water-soluble polymer support.”Bioorganic & Medicinal ChemistryLetters.  2011, 17,5041-5044.

14. Tiehai Li, Lina Guo, Zhonghua Li, Jiajia Wang,Jing Li^*, Wei Zhao^*, Recent progress in O-GlcNAcase inhibitors. Progress in Chemistry. 2011, vol 23,1657-1664.

13.TiehaiLi, Lina Guo, Yan Zhang, Jiajia Wang, Zhonghua Li, Lin Lin, Zhenxing Zhang, Lei Li, Jianping Lin, WeiZhao^*, Jing Li^*andPeng George Wang^*,“Design and synthesis of O-GlcNAcase inhibitors via ClickChemistry and biological evaluations.”Carbohydrate Research. 346 (2011) 1083-1092.

12.  Tiehai Li, Lina Guo, Yan Zhang, Jianping Lin,Jiajia Wang, Zhenxing Zhang, Jing Li, Wenpeng Zhang, Wei Zhao^* and Peng George Wang^*, “Structure-activity relationships in a series ofC2-substituted gluco-configured tetrahydroimidazopyridines as β-glucosidaseinhibitors”. Bioorganic & Medicinal Chemistry. 19 (2011) 2136-2144.

11. Yanyan Wang,Srinivas Chalagalla, Tiehai Li, Xue-long Sun, Wei Zhao,Peng G. Wang, Xiangqun Zeng^*,“Multivalent interaction-based carbohydrate biosensors for signalamplification”. Biosensors andBioelectronics 26 (2010) 996-1001.

10.  Jinhua Wang,Vinh Dang, Wei Zhao,Dongning Lu, Brian K. Rivera, Frederick A. Villamena, Peng George Wang,Periannan Kuppusamy^*.“Perchlorotrityl radical-fluorophore conjugates as dual fluorescence and EPRprobes for superoxide radical anion.” Bioorganic& Medicinal Chemistry. 18 (2010) 922-929.

9.  Wen Yi, Xianwei Liu, Yanhong Li, Jianjun Li,Chengfeng Xia, Guangyan Zhou, Wenpeng Zhang, WeiZhao, Xi Chen and Peng George Wang^*,“Remodeling Bacterial Polysaccharides by Metabolic Pathway Engineering.” Proceedings of the National Academy ofSciences, 2009, 106(11), 4207-4212.

8.  Cai, Li; Guan, Wanyi; Wang, Wenjun; Zhao,Wei; Kitaoka, Motomitsu; Shen, Jie;O'Neil, Crystal; Wang, Peng George^*, “Substrate specificity ofN-acetylhexosamine kinase towards N-acetylgalactosamine derivatives.” Bioorganic & Medicinal ChemistryLetters. 2009, 19,5433-5435.

7.  Wei-Qun Shi, Jia Hu, Wei Zhao,Yan-Mei Li^*, “Identification of radiation-induced cross-linkingbetween thymine and tryptophan by electrospray ionization-massspectrometry.”  Journal of Mass Spectrometry Vol. 41, Issue 9, pp. 1205-1211.

6.  Yong-Xiang Chen,Wei Zhao, Lei Zhao, Yu-Fen Zhao, Yan-Mei Li*, “Facilesynthesis of a pentasaccharide mimic of a fragment of the capsularpolysaccharide of Streptococcus pneumoniae type 15C.” Carbohydrate Research. 2008, 343, 4,607-614.  

5. Wei Zhao, Fanzuo Kong*,“Facile synthesis of the heptasaccharide repeating unit of O-deacetylated GXMof C. neoformans serotype B”. Bioorganic& Medicinal Chemistry 13 (2005) 121-130.

4. Wei Zhao,Fanzuo Kong*, “Synthesis of a hexasaccharide fragment of the O-deacetylatedGXM of C. neoformans serotype B”. CarbohydrateResearch.  339 (2004) 1779-1786.

3. Wei Zhao,Guangbin Yang, Fanzuo Kong*, “Synthesis of two heptasaccharideanalogues of the Lentinan repeating unit”. CarbohydrateResearch. 338 (2003) 2813-2823.

2. Wei Zhao,Fanzuo Kong*, “Synthesis of Analogues of (1-6)-Branched (1-3)-Glucohexaose”.  Journalof Carbohydrate Chemistry. Vol. 23, No. 8-9, pp. 453-464, 2004.

1. Wei Zhao, Fanzuo Kong*, “Synthesis of a heptasaccharidefragment of the O-deacetylated GXM of C. neoformans serotype C”. Carbohydrate Research.  340 (2005) 1673-1681.

参编著作

Wei Zhao, Tiehai Li, Robert Woodward, Chengfeng Xia, Peng George Wangand Wanyi Guan. “Enzymatic Synthesis of Complex Carbohydrates”. ComprehensiveNatural Products Chemistry II. Volume 6. Elsevier 2010, 5-54.