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陈瑶，南开大学药物化学生物学全国重点实验室教授，博导、国家优青、天津市杰青。研究长期聚焦生物大分子的限域精准固定及相关剂型工程研究，从分子水平阐释生物大分子与载体的相互作用与组装机制，创建晶态高性能制剂平台。承担国家重点研发计划、国家优秀青年科学基金、国自然面上、天津市重点等国家级、省部级科研项目10余项，与多个企业合作横向项目及相关应用转化。发表论文140篇，近5年来以通讯作者在Nat Protoc、Nat Commun、Nat Rev Chem、J Am Chem Soc、Angew Chem Int Ed、Adv Mater、 Chem、ACS Catal、ACS Cent Sci、Chem Soc Rev 等重要期刊发表论文54 篇（论文篇均IF>10）。论文他引超过9360次，13篇论文入选ESI高被引。获批或申请中国专利42件、PCT2 件和美国专利3 件；获得全球华人化工杰出青年女科学家奖、侯德榜化工科技青年奖、天津市科技进步特等奖、山东省科技进步一等奖，第七届中国国际互联网加创新创业大赛银奖、国家自费留学生奖等奖项；任中国化工学会理事、女科委委员，中国化工学会生物化工专委会委员，中国生物医药技术学会生物制药分会委员，担任国家自然科学基金委、科技部和欧洲研究委员会项目评审专家，任CCL、Particuology、Biodesign Research等期刊编委。
研究方向：陈瑶课题组长期致力于发展生物大分子固定化制剂平台、新型生物医药材料及相关应用转化（如生物药、新型制剂及生物催化等），并对其生物安全性和相关机制进行深入探讨。主要研究内容：
1．新型生物制剂、酶制剂和生物医药材料的开发（生物药、生物催化、制剂、药物递送等）
2．开发基于生物分子和新型多孔材料的高性能新型分离介质，用于天然产物、手性药物等的高效分离和制备;
3. 基于对蛋白、多肽等生物分子结构和功能的深入解析，进行新型药物及剂型的开发。
4. 面向生物医药、能源等领域，开发新的仿生以及生物催化体系;
通讯地址：天津市津南区同砚路38号，南开大学津南校区综合实验楼B503
电子邮件：chenyao@nankai.edu.cn
课题组网站：https://www.x-mol.com/groups/chen-yao
主持国家重点研发计划子课题、国家优秀青年科学基金、国家自然科学基金面上、青年基金等国家级、省部级项目十余项，并主持多项与企业合作的科研成果转化项目。
部分代表性论文：
1.Zixuan Wang, Yingxiao Sun, Peijie Dong, Jinhu Wang, Lijie Wang, Aili Zhao, Guangmin Qu, Hang Li, Kannapathirage Dilini Maheshika Gunarathne, Wen Zhang, Yao Chen*, Xin Meng*, Thermosensitive-based synergistic antibacterial effects of novel LL37@ZPF-2 loaded poloxamer hydrogel for infected skin wound healing, International Journal of Pharmaceutics, 2025, 670,125210.（IF：5.3）
2.Haiqun Jin, Xiujun Zhang, Xiaoqing Ma, Xin Meng, Zhenguang Lin, Xiaoyuan Li, Guojie Hu, Yao Chen*. Utilization of the Shensheng-Piwen changed medicinal powder extracts combines metal-organic frameworks as an antibacterial agent, Front. Cell. Infect. Microbiol. , 2024, 14.（IF：4.6）
3.Zhu Q, Dong P., Yu J., Wang Z., Wang T., Qiao S., Liu J., Geng S., Zheng Y., Cheng P., Zaworotko M.J., Zheng Z.*, and Chen Y.*. COF cap2: a Recyclable Tandem Catalysis Reactor for Nitrogen Fixation and Conversion to Chiral Amines， Nat. commun., 2025, 16, 992.（IF：14.7）
4.Mingfang Yang, Yunlong Zheng, Yuqing Cai, Jinbiao Guo, Along Zuo, Jiangyue Yu, Sainan Zhang, Zhenjie Zhang, and Yao Chen*. Highly Efficient Chiral Separation Based on Alkali-proof Protein Immobilization by Covalent Organic Frameworks, Angew. Chem. Int. Ed. 2024, e202420269. （IF：16.1）
5.Liqin Hao, Qianqian Zhu, Xueling Qiao, Qiongyu Shi, Yujie Liu, Tonghai Wang, En Lin, Cheng Peng, Zhenjie Zhang, Yao Chen*. Fast Production of Covalent Organic Frameworks for Covalent Enzyme Immobilization with Boosted Enzymatic Catalysis by Solar-Driven Photothermal Effect.（IF：16.1）
6.Dong Zheng, Yunlong Zheng, Junjie Tan, Zhenjie Zhang, He Huang, and Yao Chen*. Co-immobilization of whole cells and enzymes by covalent organic framework for biocatalysis process intensification, Nature commun., 2024, 15, 5510.（IF：14.7）
7.Sa Wang,Wansheng Liu,Jian Wang, Jiangyue Yu, Fengdong Wang, Chaonan Jin,Kaiyuan Wang, Peng Cheng, Zhenjie Zhang,*and Yao Chen*. Mechanochemical Encapsulation of Enzymes into MOFs for Photoenzymatic Enantioselective Catalysis, ACS materials lett., 2024, 6, 7, 2609–2616（IF：9.6）
8.Qianqian Zhu, Yunlong Zheng, Zhenjie Zhang*, Yao Chen*, Enzyme Immobilization on Covalent Organic Framework Supports, Nature Protocols, 2023, 18, 3080–3125（IF：13.1）
9. Jinxia Wei, Rui Li, Penghui Zhang, Haiqun Jin, Zhenjie Zhang, Yubo Li*, Yao Chen*, Efficient selective removal of uremic toxin precursor by olefin-linked covalent organic frameworks for nephropathy treatment. Nat Commun 14, 2023, 2805.（IF：14.7）
10.Yifan Feng+, Ruixuan Shi+, Mingfang Yang+, Yunlong Zheng[a], Zhenjie Zhang and Yao Chen*, A Dynamic Defect Generation Strategy for Efficient Enzyme Immobilization in Robust Metal-Organic Frameworks for Catalytic Hydrolysis and Chiral Resolution. Angew. Chem. Int. Ed. 2023, e202302436（IF：16.1）
11. Zhifang Wang, Qianqian Zhu, Jiaxi Wang, Fazheng Jin, Penghui Zhang, Dong Yan, Peng Cheng, Yao Chen*, Zhenjie Zhang*, Industry-compatible covalent organic frameworks for green chemical engineering. Sci. China Chem, 2022,65. (IF:10.138)（IF：10.4）
12. Yunlong Zheng, Sainan Zhang, Jinbiao Guo, Ruixuan Shi, Jiangyue Yu, Kaipeng Li, NingLi, ZhenjieZhang, and Yao Chen*, Green and Scalable Fabrication of High-Performance Biocatalysts Using Covalent Organic Frameworks as Enzyme Carriers, Angew. Chem. Int. Ed. 2022, e202208744. (IF:16.823)（IF：16.1）
13. Zhengfeng Zhao,* Xuepeng Chen, BaoYing Li, Shu Zhao, Liwei Niu,* Zhenjie Zhang, and Yao Chen*, Spatial Regulation of Acceptor Units in Olefin-Linked COFstoward Highly Efficient Photocatalytic H2Evolution, Adv. Sci. 2022, 2203832. (IF:17.521)
14. Chaonan Jin, Ning Li, En Lin, Xuepeng Chen, Ting Wang, Yan Wang, Mingfang Yang, Wansheng Liu, Jiangyue Yu, Zhengjie Zhang, Yao Chen*, Enzyme Immobilization in Porphyrinic Covalent Organic Frameworks for Photoenzymatic Asymmetric Catalysis, ACS Catal. 2022, 12, 8259- 8268. (IF:13.700)
15. Jinjin Liu, Zhifang Wang, Peng Cheng, Michael Zaworotko, Yao Chen* and Zhenjie Zhang*, Post-Synthetic Modifications of Metal-Organic Cages, Nat. Rev. Chem. 2022, 6, 339-356. (IF:34.571)
16.Zhengfeng Zhao+, Dong Zheng+, Menglei Guo, Jiangyue Yu, Sainan Zhang, Zhenjie Zhang,and Yao Chen*, Engineering Olefin-Linked Covalent Organic Frameworks for Photoenzymatic Reduction of CO2, Angew. Chem. Int. Ed. 2022, 61, e202200261. (IF:16.823)
17. Wen Duan#,Shan Qiao#, Mingjing Zhuo, Jiaxing Sun, Menglei Guo, Fei. Xu, JinjinLiu, Ting Wang, Xiuxiu Guo, Yan Zhang, Jia Gao, Yueyun Huang, Zhenjie Zhang, PengCheng, Shengqian Ma*, Yao Chen*, Multifunctional Platforms:Metal-Organic Frameworks for Cutaneous and Cosmetic Treatment. Chem, 2021, 7, 450-462. (IF: 22.804)
18. ZhengfengZhao, Yunlong Zheng, Chun Wang, Sainan Zhang, Jie Song, Yafei Li, Shengqian Ma,Peng Cheng, Zhenjie Zhang*, Yao Chen*, Fabrication of Robust CovalentOrganic Frameworks for Enhanced Visible-Light-Driven H2 Evolution, ACSCatal., 2021, 11, 2098–2107(IF: 13.084)
19. JieDong, Hong-De An, Ze-Kun Yue, Sheng-Li Hou, Yao Chen*, Zhen-Jie Zhang, Peng Cheng, Qian Peng*, Bin Zhao*,Dual-Selective Catalysis in Dephosphorylation Tuned by Hf6-ContainingMetal–Organic Frameworks Mimicking Phosphatase, ACS Central Sci.,2021, 7, 831-840 (IF:14.553)
20. HongdeAn, Jie Song, Ting Wang, Nannan Xiao, Zhenjie Zhang, Peng Cheng, Shengqian Ma,He Huang, Yao Chen *, Metal-Organic Framework Disintegrants: Enzyme PreparationPlatforms with Boosted Activity. Angew.Chem. Int. Ed. 2020, 59 (38),16764-16769. (IF: 15.336)
21. MingminLi, Shan Qiao, Yunlong Zheng, Yassin H Andaloussi, Xia Li, Zhenjie Zhang, AngLi, Peng Cheng, Shengqian Ma, Yao Chen*,Fabricating Covalent Organic Framework Capsules with CommodiousMicroenvironment for Enzymes. J. Am. Chem. Soc. 2020, 142:6675-6681. (IF: 15.419)
22. HuanrongWang#, Lin Han#, Dong Zheng, Mingfang Yang, Yassin H.Andaloussi, Peng Cheng, Zhenjie Zhang, Shengqian Ma, Michael J. Zaworotko,Yifan Feng, Yao Chen*，Protein-Structure-DirectedMetal-Organic Zeolite-like Networks as Biomacromolecule Carriers.Angew. Chem. Int. Ed. 2020, 59,6263-6267. (IF: 15.336)
23. Zhifang Wang#, Sainan Zhang#,Yao Chen*, Zhenjie Zhang*, Shengqian Ma*, Covalent Organic frameworks forseparation applications. Chem. Soc. Rev.2020, 9, 708-735 (IF：54.564）
24. Jinjin Liu, Wenjie Duan, Jie Song, Xiuxiu Guo,Zhifang Wang, Xinlei Shi, Jiajie Liang, Juan Wang, Peng Cheng, Yao Chen*, Michael J. Zaworotko*,Zhenjie Zhang*. Self-Healing Hyper-Cross-Linked Metal–Organic Polyhedra(HCMOPs) Membranes with Antimicrobial Activity and Highly Selective SeparationProperties. J. Am. Chem. Soc. 2019,141, 12064-12070. (IF: 15.419)
25. Zhifang Wang, Qi Yu, Yubo Huang, Hongde An, YuZhao, Yifan Feng, Xia Li, Xinlei Shi, Jiajie Liang, Fusheng Pan, Peng Cheng, Yao Chen*, Zhenjie Zhang*, ShengqianMa*. PolyCOFs: A New Class of Freestanding Responsive Covalent OrganicFramework Membranes with High Mechanical Performance. ACS Cent Sci. 2019, 5, 1352-1359. (IF:14.553)
26. Sainan Zhang, YunlongZheng, Hongde An, Briana. Aguila, Chengxiong Yang, YueyueDong, Wei Xie, Peng Cheng, Zhenjie Zhang*, Yao Chen*, ShengqianMa*. Covalent Organic Frameworks with Chirality Enriched by Biomolecules forEfficient Chiral Separation. Angew. Chem.Int. Ed. 2018, 57, 16754–16759. (IF:15.336)
27.Yifan Feng, Huanrong Wang, Sainan Zhang, Yu Zhao, Jia Gao,Yunyi Zheng, Peng Zhao, Zhenjie Zhang, Michael J. Zaworotko, Peng, Cheng,Shengqian Ma*, Yao Chen*.Antibodies@MOFs: An In Vitro Protective Coating for Preparation and Storage ofBiopharmaceuticals. Adv. Mater., 2019,1805148 （封面文章，IF: 30.849）
28.An, Hongde#; Li, Mingmin#;Gao, Jia; Zhang, Zhenjie; Ma, Shengqian; Chen,Yao*, Incorporation of biomolecules in Metal-Organic Frameworks foradvanced applications, Coordination Chemistry Reviews, 2019, 384, 90-106. (IF: 22.316)
29.Yao Chen, Vasiliki Lykourinou, Carissa Vetromile, Tran Hoang, Li-JuneMing, Randy W. Larsen, Shengqian Ma*, How canproteins enter the interior of a MOF? Investigation of cytochrome ctranslocation into a MOF consisting of mesoporous cages with microporouswindows. J. Am. Chem. Soc.,2012, 134, 13188-13191. (IF: 15.419)
30. VasilikiLykourinou§, Yao Chen§, Xi-Sen Wang, LeMeng, Tran Hoang, Li-June Ming*, R. L. Musselman and Shengqian Ma*, Immobilization of MP-11 into a mesoporous metal–organicframework, MP-11@ mesoMOF: a new platform for enzymatic catalysis. J. Am. Chem. Soc., 2011, 133,10382-10385. (§共同一作) (IF: 15.419)
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