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余志林,南开大学化学学院研究员暨药物化学生物学国家重点实验室课题组组长,博导,国家海外青年人才计划入选者。
主要研究方向为基于多肽可控自组装的生物医用功能材料制备。研究方法结合仿生设计与源头(de novo)设计策略,合成非传统氨基酸分子调控多肽非共价作用,实现多肽精准组装,构筑具有特定结构特征的新型超分子聚合物和软物质材料,探索多肽纳米结构在多肽药物、生物检测、疾病治疗等领域的应用。取得了一系列创新性研究成果,以第一作者或者通讯作者发表于Science,J. Am. Chem. Soc.,Angew. Chem. Int. Ed.,Nano Letters,Nano Today, Chemical Science等具有国际知名期刊上,受到了国内外同行的高度评价和Science Daily,Science News,Chem & Eng News,Phys. Org.,NPG Asia Materials等权威媒体杂志的亮点推荐及广泛报道。
教育及工作经历:
2017年-至今:南开大学高分子化学研究所
2013年-2017年:美国西北大学,博士后(导师:Prof. Samual I. Stupp)
2009年-2013年:德国柏林洪堡大学化学系,博士(导师:Prof. Stefan Hecht)
2006年-2009年:南开大学元素有机化学所,硕士(导师:刘育教授)
2002年-2006年:天津大学化学系,理学学士
荣誉和奖励
2017年入选国家海外青年人才计划
2013年获德国柏林-布莱登堡高分子协会Georg-Manecke奖
2013年获柏林洪堡大学Fischer-Nernst奖
2008年获南开大学化学学院‘杨石先’奖
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支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg代表性研究成果:
1、Binbin Hu, Na Song, Yawei Cao, Mingming Li, Xin Liu, Zhifei Zhou, Linqi Shi, and Zhilin Yu.* Noncanonical Amino Acids for Hypoxia-Responsive Peptide Self-Assembly and Fluorescence. J. Am. Chem. Soc. 2021, 143, 13854–13864.
2、Mingming Li, Yanqiu Song, Na Song, Guangyao Wu, Hao Zhou, Jiafu Long, Pengcheng Zhang, Linqi Shi, Zhilin Yu.* Supramolecular Antagonists Promote Mitochondrial Dysfunction. Nano Letters 2021, 21, 5730-5737.
3、Na Song, Zhifei Zhou, Yanqiu Song, Mingming Li, Xiunan Yu, Binbin Hu, Zhilin Yu.* In situ oxidation-regulated self-assembly of peptides into transformable scaffolds for cascade therapy. Nano Today 2021, 38, 101198.
4、Mingming Li, Zhongyan Wang, Xin Liu, Na Song, Yanqiu Song, Xuefeng Shi, Jinjian Liu,* Jianfeng Liu,* and Zhilin Yu.* Adaptable Peptide-Based Therapeutics Modulating Tumor Microenvironment for Combinatorial Radio-Immunotherapy. J. Control. Release 2021, 340, 35-47.
5、Shuxin Song, Jingyu Wang,* Zhifei Cheng, Zhimou Yang, Linqi Shi, Zhilin Yu.* Directional molecular sliding movement in peptide hydrogels accelerates cell proliferation. Chemical Science 2020, 11, 1383-1393.
6、Zhifei Cheng,# Yuanyuan Cheng,# Qian Chen, Mingming Li, Jie Wang, Hui Liu, Mengwen Li, Yashan Ning, Zhilin Yu,* Yinsong Wang,* Hao Wang.* Self-assembly of pentapeptides into morphology-adaptable nanomedicines for enhanced combinatorial chemo-photodynamic therapy. Nano Today 2020, 33, 100878.
7、Mingming Li,# Yashan Ning,# Jialiang Chen, Xingchen Duan, Na Song, Dan Ding,* Xuncheng Su,* Zhilin Yu.* Proline Isomerization-Regulated Tumor Microenvironment-Adaptable Self-Assembly of Peptides for Enhanced Therapeutic Efficacy. Nano Letters 2019, 19, 7965-7976.
8、Shaofeng Lou, Xinmou Wang, Zhilin Yu,* Linqi Shi.* Peptide Tectonics: Encoded Structural Complementarity Dictates Programmable Self‐Assembly. Advanced Science 2019, 6, 1802043.
9、Zhilin Yu,# Aykut Erbas,# Faifan Tantakitti, Liam C. Palmer, Joshua A. Jackman, Monica Olvera de la Cruz,* Nam-Joon Cho,* Samuel I. Stupp.* Co-Assembly of Peptide Amphiphiles and Lipids into Supramolecular Nanostructures Driven by Anion-π Interactions’, J. Am. Chem. Soc. 2017, 139, 7823-7830.
10、Zhilin Yu, Faifan Tantakitti, Tao Yu, Liam C. Palmer, George Schatz, Samuel I. Stupp.* Simultaneous Covalent and Non-Covalent Hybrid Polymerizations. Science, 2016, 351, 497-502.
11、Zhilin Yu, Faifan Tantakitti, Liam C. Palmer, Samuel I. Stupp.* Asymmetric Peptide Nanoribbons. Nano Letters 2016, 16, 6967-6974.
12、Zhilin Yu, Stefan Hecht.* Control over Unfolding Pathways by Localizing Photoisomerization Events within Heterosequence Oligoazobenzene Foldamers. Angew. Chem. Int. Ed. 2013, 52, 13740-13744.
13、Zhilin Yu, Steffen Weidner, Thomas Risse,* Stefan Hecht.* The Role of Statistics and Microenvironment for The Photoresponse in Multi-Switch Architectures: The Case of Photoswitchable Oligoazobenzene Foldamers. Chemical Science 2013, 4, 4156-4167.
14、Zhilin Yu, Stefan Hecht.* Reversible and Quantitative Denaturation of Amphiphilic Oligo(azobenzene) Foldamers. Angew. Chem. Int. Ed. 2011, 50, 1640-1643.
15、Yu Liu,* Zhilin Yu, Yingming Zhang, Dongsheng Guo, Yuping Liu, Supramolecular Architectures of beta-Cyclodextrin-Modified Chitosan and Pyrene Derivatives Mediated by Carbon Nanotubes and their DNA Condensation. J. Am. Chem. Soc. 2008, 130, 10431-10439.
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