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主要从事生物医用超分子材料的研究工作。围绕生物活性物质的高效识别这一关键科学问题, 以超分子大环主体为核心工具, 建立了定量负载和比率递送的主客体载药模型,提出了共组装杂多价识别生物大分子新策略,构建了功能多元的模块化超分子材料库。研究工作为肿瘤和阿尔茨海默病等重大疾病的早期诊断、预防和治疗发展了新的超分子材料和策略,有效促进了生物医用材料的精准化发展。目前已在Nat. Chem.、Nat. Commun.、Adv. Mater.、Proc. Natl. Acad. Sci. U.S.A.、J. Am. Chem. Soc.、Angew. Chem. Int. Ed.等刊物上发表论文220余篇,他引9800余次。申请中国发明专利45件,授权29件。做学术报告180余次。2013年获国家优秀青年科学基金资助,入选南开大学百名青年学科带头人培养计划;2014年入选天津市青年拔尖人才支持计划,天津市创新人才推进计划青年科技优秀人才;2018年先后入选天津市、科技部创新人才推进计划中青年科技创新领军人才;2019年入选第四批国家“万人计划”科技创新领军人才。2015年获天津市自然科学一等奖;2019年获第十五届天津青年科技奖;2020年获首届南开大学科学研究奖青年创新奖;2022年获第四届中国化学会超分子化学青年创新学术讲座奖。目前担任《中国化学快报》编委,《Supramolecular Materials》编委,《Responsive Materials》青年编委,《Frontiers in Chemistry》编委,天津科技大学学报编委,中国抗癌协会医工整合专业委员会常务委员,生物资源材料与再生医学学术大会学术委员会委员,全国光功能材料青年学者研讨会学术委员会委员,第五届抗菌科学与技术论坛学术委员会委员,天津市耐高温工业酶企业重点实验室学术委员会委员,中国感光学会青年理事,天津市化学会理事, 天津市青年科技工作者协会会员,2020年晋升为中国化学会高级会员。
课题组主页:http://www.calixer.cn/
课题组正在承担国家、省部级等各类项目,累计金额超过1000万元。
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支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg课题组正在承担国家、省部级等各类项目,累计金额超过1000万元。
近期重点项目如下:
1、第四批国家“万人计划”科技创新领军人才,80万元、结题、主持。
2、天津市科技计划项目(24ZYJDSS00300),“基于中药材质量快速评价及高通量制备的祛风化湿类等中药组分库建设”、2024/01-2025/09、210万元、在研、参与。
3、国家自然科学基金面上项目(22371147),“两性离子修饰两亲杯芳烃的设计合成及其药物递送研究”、2024/01-2027/12、50万元、在研、主持。
4、国家自然科学基金区域创新发展联合基金重点项目(U20A20259),“乏氧响应的主客体药物递送体系”、2021/01-2024/12、262万元、结题、主持。
5、南开大学—沧州渤海新区绿色化工研究院孵化基金项目,“新型超分子药用辅料的研发”、250万元、结题、主持
6、国家自然科学基金国际(地区)合作与交流项目(中巴,31961143004),“减负增效超分子抗肿瘤纳米药物”、2019/07-2022/06、175万元、结题、主持。
代表性论著:
(1) Zhe Xu, Shaorui Jia, Wei Wang, Zhi Yuan, Bart JanRavoo*, and Dong-Sheng Guo*, Heteromultivalentpeptide recognition by co-assembly of cyclodextrin and calixarene amphiphilesenables inhibition of amyloid fibrillation, Nat. Chem., 2019,11, 86–93.
(2) Shun-Yu Yao, An-Kang Ying, Ze-Tao Jiang, Yuan-QiuCheng, Wen-Chao Geng, Xin-Yue Hu, Kang Cai*, and Dong-Sheng Guo*,Single molecular nanomedicines based on macrocyclic carrier-drug conjugates forconcentration-independent encapsulation and precise activation of drugs, J.Am. Chem. Soc., 2024, 146, 14203–14212.
(3) Jie Gao, Jun Li, Wen-Chao Geng, Fang-Yuan Chen,Xingchen Duan, Zhe Zheng, Dan Ding*, and Dong-Sheng Guo*,Biomarker displacement activation: a general host-guest strategy for targeted phototheranosticsin vivo, J. Am. Chem. Soc., 2018, 140, 4945–4953.
(4) Fang-Yuan Chen, Cheng-Zhi Li, Han Han, Wen-ChaoGeng, Shu-Xin Zhang, Ze-Tao Jiang, Qing-Yu Zhao, Kang Cai*, and Dong-ShengGuo*, Expanding the hydrophobic cavity surface of azocalix[4]areneto enable biotin/avidin affinity with controlled release, Angew. Chem.Int. Ed., 2024, 63, e202402139.
(5) RuiguoWang, Wen-Bo Li, Jia-Ying Deng, Han Han, Fang-Yuan Chen, Dai-Yuan Li, Li-BoJing, Zihang Song, Rong Fu, Dong-Sheng Guo*, and Kang Cai*,Adaptive and ultrahigh-affinity recognition in water by sulfated conjugated corral[5]arene,Angew. Chem. Int. Ed., 2024, 63, e202317402.
(6) Shun-Yu Yao, Yu-Xin Yue, An-Kang Ying, Xin-YueHu, Hua-Bin Li, Kang Cai*, and Dong-Sheng Guo*, Anantitumor dual-responsive host-guest supramolecular polymer based on hypoxia-cleavableazocalix[4]arene, Angew. Chem. Int. Ed., 2023, 62,e202213578.
(7) Xin-Yue Hu, Dong-Sheng Guo*, Superchaotropicboron clusters as membrane carriers for the transport of hydrophilic cargos, Angew.Chem. Int. Ed., 2022, 61, e202204979.
(8) Wen-Chao Geng#, Zhongju Ye#,Zhe Zheng, Jie Gao, Juan-Juan Li, Muhammad Raza Shah, Lehui Xiao*,and Dong-Sheng Guo*, Supramolecular bioimaging through signalamplification by combining indicator displacement assay with Förster resonance energytransfer, Angew. Chem. Int. Ed., 2021, 60,19614-19619.
(9) Yu-Chen Pan, Andrea Barba-Bon, Han-Wen Tian, FeiDing, Andreas Hennig, Werner M. Nau, and Dong-Sheng Guo*, Anamphiphilic sulfonatocalix[5]arene as a novel activator for membrane transportof lysine‐rich peptides and proteins, Angew. Chem. Int. Ed., 2021,60, 1875-1882.
(10) Yu-Chen Pan, Xin-Yue Hu, and Dong-Sheng Guo*,Biomedical applications of calixarenes: state‐of‐the‐art and perspectives, Angew.Chem. Int. Ed., 2021, 60, 2768-2794.
(11) Wen-Chao Geng#, Dongmei Zhang#,Chu Gong, Zhihao Li, Kevin Barraza, J.L. Beauchamp*, Dong-ShengGuo*, and Xinxing Zhang*, Host-guest complexation of amphiphilicmolecules at the air-water interface prevents oxidation by hydroxyl radicalsand singlet oxygen, Angew. Chem. Int. Ed., 2020, 59,12684-12688.
(12) Wen-Chao Geng, Shaorui Jia, Zhe Zheng, Zhihao Li,Dan Ding, and Dong-Sheng Guo*, A noncovalent fluorescenceturn‐on strategy for hypoxia imaging, Angew. Chem. Int. Ed., 2019,58, 2377-2381.
(13) Shu Peng, Andrea Barba-Bon, Yu-Chen Pan, WernerM. Nau, Dong-Sheng Guo*, and Andreas Hennig*,Phosphorylation-responsive membrane transport of peptides, Angew. Chem.Int. Ed., 2017, 56, 15742–15745.
(14) Wen-Bo Li#, Lin-Lin Xu#,Si-Lei Wang, Ying-Yue Wang, Yu-Chen Pan*, Lin-Qi Shi*,and Dong-Sheng Guo*, Co-assembled nanoparticles towards multi-targetcombinational therapy of alzheimer's disease by making full use of molecular recognitionand self-assembly, Adv. Mater., 2024, 36, 2401918.
(15) Shihui Li, Rong Ma, Xin-Yue Hu, Hua-Bin Li,Wen-Chao Geng, Xianglei Kong, Chao Zhang, and Dong-Sheng Guo*,Drug in drug: A host–guest formulation of azocalixarene with hydroxychloroquinefor synergistic anti-inflammation, Adv. Mater., 2022, 34,2203765.
(16) Yu-Chen Pan, Yu-Xin Yue, Xin-Yue Hu, Hua-Bin Li,and Dong-Sheng Guo*, A supramolecular antidote tomacromolecular toxins prepared through co-assembly of macrocyclic amphiphiles, Adv.Mater., 2021, 33, 2104310.
(17) Zhanzhan Zhang#, Yu-Xin Yue#,Lina Xu, Ying Wang, Wen-Chao Geng, Juan-Juan Li, Xianglei Kong, Zhixin Zhao,Yadan Zheng, Yu Zhao, Linqi Shi*, Dong-Sheng Guo*,and Yang Liu*, Macrocyclic amphiphile-based self-assemblednanoparticles for ratiometric delivery of therapeutic combinations to tumour, Adv.Mater., 2021, 33, 2007719.
(18) Hui Wang, XinXin Xu, Yu-Chen Pan, YuXing Yan,Xin-Yue Hu, RunWen Chen, Bart Jan Ravoo, Dong-Sheng Guo*, andTao Zhang*, Recognition and removal of amyloid-β by a heteromultivalentmacrocyclic coassembly: a potential strategy for the treatment of alzheimer's disease,Adv. Mater., 2021, 33, 2006483.
(19) Tian-Xing Zhang#, Zhan-Zhan Zhang#,Yu-Xin Yue#, Xin-Yue Hu, Fan Huang*, Linqi Shi*,Yang Liu*, and Dong-Sheng Guo*, A general hypoxia-responsivemolecular container for tumor-targeted therapy, Adv. Mater., 2020,32, 1908435.
(20) Zhe Xu, Shu Peng, Yu-Ying Wang, Ji-Kai Zhang,Alexandra I. Lazar, and Dong-Sheng Guo*, Broad-spectrum tunablephotoluminescent nanomaterials constructed from a modular light-harvesting platformbased on macrocyclic amphiphiles, Adv. Mater., 2016, 28,7666–7671.
(21) Fang-Yuan Chen, Wen-Chao Geng, Meng-Meng Chen,Rong Fu, Han Han, Zhan-Zhan Zhang, Wen-Bo Li, Yuan-Qiu Cheng, Juan-Juan Li, J.Fraser Stoddart*, Kang Cai*, and Dong-Sheng Guo*,Assembly enhanced recognition: A biomimetic pathway to achieve ultrahighaffinities, Proc. Natl. Acad. Sci. U.S.A., 2025, 122,e2414253122.
(22) Jia-Hong Tian#, Siyuan Huang#,Ze-Han Wang, Juan-Juan Li, Xianhui Song, Ze-Tao Jiang, Bing-Sen Shi, Ying-YingZhao, Hui-Yan Zhang, Ke-Rang Wang, Xin-Yue Hu*, Xinge Zhang*,and Dong-Sheng Guo*, Supramolecular discrimination anddiagnosis-guided treatment of intracellular bacteria, Nat.Commun.,2025, 16, 1016.
(23) Wenyan Wang#, Shun-Yu Yao#,Jingjing Luo, Chendi Ding, Qili Huang, Yao Yang, Zhaoqing Shi, Jiachan Lin,Yu-Chen Pan, Xiaowei Zeng*, Dong-Sheng Guo*, andHongzhong Chen*, Engineered hypoxia-responsive albumin nanoparticlesmediating mitophagy regulation for cancer therapy, Nat. Commun., 2025,16, 596.
(24) Jian-Shuang Guo#, Juan-Juan Li#,Ze-Han Wang, Yang Liu, Yu-Xin Yue, Hua-Bin Li, Xiu-He Zhao, Yuan-Jun Sun,Ya-Hui Ding, Fei Ding, and Dong-Sheng Guo*, Liang Wang*,and Yue Chen, Dual hypoxia-responsive supramolecular complex for cancer target therapy,Nat. Commun., 2023, 14, 5634.
(25) Juan-Juan Li#, Yuqing Hu#,Bing Hu, Wenbo Wang, Haiqi Xu, Xin-Yue Hu, Fei Ding, Hua-Bin Li, Ke-Rang Wang*,Xinge Zhang*, and Dong-Sheng Guo*, Lactose azocalixarenedrug delivery system for the treatment of multidrug-resistant pseudomonas aeruginosainfected diabetic ulcer, Nat. Commun., 2022, 13,6279.
(26) Jia-Hong Tian#, Xin-Yue Hu#,Zong-Ying Hu, Han-Wen Tian, Juan-Juan Li, Yu-Chen Pan, Hua-Bin Li, and Dong-ShengGuo*, A facile way to construct sensor array library via supramolecularchemistry for discriminating complex systems, Nat. Commun., 2022,13, 4293.
(27) Zhe Zheng, Huijuan Yu, Wen-Chao Geng, Xin-Yue Hu,Yu-Ying Wang, Zhihao Li, Yuefei Wang, and Dong-Sheng Guo*,Guanidinocalix[5]arene for sensitive fluorescence detection and magneticremoval of perfluorinated pollutants, Nat. Commun., 2019, 10,5762.
(28) Wen-Chao Geng, Jonathan L. Sessler*,and Dong-Sheng Guo*, Supramolecular prodrugs based onhost-guest interactions, Chem. Soc. Rev., 2020, 49,2303-2315.
(29) Yu-Chen Pan, Jia-Hong Tian, and Dong-Sheng Guo*,Molecular recognition with macrocyclic receptors for application in precisionmedicine, Acc. Chem. Res., 2023, 56, 3626-3639.
(30) Xin-Yue Hu, Rong Fu, and Dong-Sheng Guo*,Hypoxia-responsive host-guest drug delivery system, Acc. Mater. Res.,2023, 4, 925-938.
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