个人信息
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个人简介
Personal Profile
教育及科研经历:
1986-09至1990-07,北京化工大学,应用化学系,学士
2000-09至2005-06,南开大学,化学学院,博士
1990-07至2000-08,天津化工厂,工程师
2005-07至2024-12, 南开大学,化学学院,副教授
2024-12至今,南开大学,化学学院,教授
2016-07至2017-07,美国加州大学圣巴巴拉分校,访问学者
研究领域:
新颖实用的有机合成研究和合成方法的探索; 药物分子的设计、合成及生物学评价; 精细化学品合成及工艺研究。
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支持扩展名:.rar .zip .doc .docx .pdf .jpg .png .jpeg参加国家重大项目1项,主持国家自然科学基金面上项目2项,天津市重点项目1项,天津市面上项目2项,并参加多项国家基金项目的研究工作。主持多项应用项目。
1. I. Djavani-Tabrizi, Z. Q. Yuan, T. T. Lindkvist, J. M. Xing, L. Chen,* S. B. Nielsen*, Gas-Phase Fluorescence Excitation Experiments on Cryogenically Cold Rhodamine B Cations Linked to Various Amino Acid Esters, J. Am. Soc. Mass Spectrom. 2025, 36, 409−415.
2. Catalytic Asymmetric Reactions of Ketimines and Alkenes via [2+2] Cycloaddition: Chemical Reactivity Controlled by Switching a Heteroatom, Q. Zhao, Y. Li, Z. Y. Ren, Y. B. Shao, L. Chen*, X. Li*, J.Am. Chem. Soc., 2024, 146, 32088-32097
3. Silver-Enabled Dearomative Trifluoromethoxylation of Indoles, Z. J. Deng, L. D. Meng, X. Bing, S. X. Niu,X. F. Zhang, J. Q. Peng, Y. X. Luan, L. Chen*, P. P. Tang*, J. Am. Chem. Soc., 2024, 146,2325-2332.
4. Enantioselective Synthesis of “NO2···NH”Hydrogen Bond-Stabilized C–N Axially Chiral Diarylamines, W. Lin, Y. B. Shao,Z. Y. Hao, Z. L. Huang, Z. Y. Ren, L. Chen*, X. Li*, ACS Catalysis, 2024, 14, 1183-1192.
5. Predicting bond dissociation energies of cyclic hypervalent halogen reagents using DFT calculations and graph attention network model, Y. Shao, Z. Ren, Z. Han, L. Chen*, Y. Li*, X. Xue*, BeilsteinJ. Org. Chem. 2024, 20, 1444–1452.
6. Asymmetric alkenylation reaction of benzoxazinones with diarylethylenes catalyzed by B(C6F5)3/chiral phosphoricacid, Z. Liu, Z. Y. Ren, C. Yang, X. Y. Shao, L. Chen*, X. Li*, Chin. Chem. Lett., 2023, 108939.
7. Asymmetric Synthesis of Axially Chiral Arylpyrazole via an Organocatalytic Arylation Reaction, X. Gao, C. W. Li, L.Chen*, X. Li*, Org. Lett., 2023, 25, 7628- 7632.
8. Synthesis and Biological Activity of Lycorine Derivatives Containing Malate Ester, Y. Zhao, L. Qiao, G. F. Zhao, L. Chen*,Chem. J. Chinese Uni., 2021, 42, 2789-2797.
9. Triangular rhodamine triads and their intrinsic photophysics revealed from gas-phase ion fluorescence experiments, Y. Zhao, E. R. Sørensen, T.T. Lindkvist, C. Kjær, M. B. Nielsen, L. Chen*, S. B. Nielsen*, Chem.Eur. J. 2021, 27, 10875–10882.
10. Gas-phase Förster resonance energy transfer in mass-selected ions with methylene or peptide linkers between two dyes: a concerted dance of charges, C. Kjær, Y. Zhao, M. H. Stockett, L. Chen*,K. Hansen*, S. B. Nelsen*, Phys. Chem. Chem. Phys, 2020, 22,11095-11100.
11. Silver-catalyzed stereoselective formation of glycosides using glycosyl ynenoates as donors, X. Dong, L. Chen*, Z.Zheng, X. Ma, Z. Luo, L. M. Zhang*, Chem. Commun., 2018, 54,8626-8629.
12. Formation of β-Lactones by [2+2] Cycloaddition of Dichloroketene with Unreactive Carbonyl Compounds, X. Dong, C. Zhang, J. Xu,Y. Zhang, Y. Zhao, L. Chen*, Chem. Research Chin. Uni., 2018, 34,736-743.
13. Asymmetric [3+2] Annulations of1,4-dithiane-2,5-diol and N-Boc Aldimines Catalyzed by Tertiary-amine Thiourea,X. Dong, F. B. Xu, L. Chen*, X. Li, Chem. J. Chinese Uni., 2018, 39,1707-1712.
14. Diastereoselective Synthesis of Cephalotaxus Esters via Asymmetric Mukaiyama Aldol Reaction, G. Z. Ma, P. F. Li, L. Liu, W.D. Li, L. Chen*, Org. Lett., 2017, 19, 2250–2253.(Highlights by Synfacts 2017, 13, 744).
专利成果
1. 陈莉,郭远强,齐明丽,乔玲,张悦,赵莹,侯剑彤;三尖杉酯类生物碱及其制备和应用;申请号:WO2024061357A1。
2. 陈莉、张悦、赵莹、徐建;侧链末端含杂环的三尖杉酯类生物碱及其制备和应用;专利号:CN110950980。
3. 陈莉,马国贞,李卫东;三尖杉酯类生物碱、其制备方法和用途;中国发明专利,专利号:CN106866690。
4. 陈莉,冯俊俊,李鹏飞;具有抗肿瘤活性的藤黄酸类似物及其制备方法和活性;中国发明专利,专利号:CN106478655A。
5. 陈莉,冯俊俊,马国贞,张春霞,李鹏飞;藤黄酸衍生物及其制备方法和应用;中国发明专利,专利号: CN103613602A 。
6. 陈莉、李卫东;高效高立体选择性半合成三尖杉酯类生物碱的方法;中国发明专利,专利号: CN102304132A。
7. 陈莉、李卫东;三尖杉酯碱类似物及制备方法和应用;中国发明专利,专利号:CN102675327A。
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