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2004-今:教授,博士生导师, 南开大学化学学院元素有机化学研究所,元素有机化学国家重点实验室固定研究人员。1999-2004: 博士后(名古屋大学,肯塔基大学)。1996-1999: 助教/副教授(南开大学元素所)。1993-1996: 博士,南开大学元素所(李正名 院士)。1990-1993: 硕士:南开大学元素所(刘天麟 教授)。1986-1990: 学士(南开大学)。
主要研究方向为天然产物复杂多环骨架构筑导向的高效、通用有机合成方法学、天然产物全合成和药物先导发现。许多具有重要生物活性的天然产物含有多环骨架,这些多环骨架普遍具有结构复杂性和多样性的特点。发展高效、通用的构筑结构复杂、多样性多环骨架的方法和策略,对于高效发现具有新颖结构骨架的药物先导具有重要的意义。提出了“偶极调控张力环的分子内交叉(IMCC)/平行(IMPC)环加成”思路,提供了一种构筑桥环、并环、中环和多环骨架的高效、通用策略,并成功地将其应用于了若干复杂天然产物的全合成中。
代表性研究论文:
1. Bao Hu, Siyang Xing, Zhongwen Wang* “Lewis AcidCatalyzed Ring-Opening Intramolecular Friedel-CraftsAlkylation of Methylenecyclopropane 1,1-Diesters” Org.Lett. 2008,10(23), 5481-5484
2. Bao Hu, Jianlin Zhu, Siyang Xing, Jie Fang, Ding Du, Zhongwen Wang* “A Highly Site-, Regio-, and Stereoselective Lewis Acid-Catalyzed Formal [3+3] Cycloaddition ofMethylenecyclopropane-1,1-Diesters with C,N-Diarylnitrones” Chem.Eur. J. 2009, 15(2), 324-327
3.DingDu, Linxia Li, Zhongwen Wang* “N-Heterocyclic Carbene-Catalyzed DominoRing-Opening/Redox Amidation/Cyclization Reactions of Formylcyclopropane1,1-Diesters: Direct Construction of a 6-5-6 TricyclicHydropyrido[1,2-a]indole Skeleton” J. Org. Chem. 2009, 74(11),4379-4382
4.YuBai, Jie Fang, Jun Ren, Zhongwen Wang* “Highly Diastereoselective Gold- or Copper-Catalyzed Formal [4+3]Cycloaddition of 1-(1-Alkynyl) Cyclopropyl Ketones and Nitrones” Chem. Eur. J. 2009, 15(36),8975-8978
5. Shaojin Chen, Jun Ren, Zhongwen Wang* “A highly regioselective tandem 1,3-dipolarcycloaddition of cyclopropene 1,1-diestersand nitrile oxides: synthesis of highly functionalized isoxazoles” Tetrahedron 2009, 65(45),9146-9151
6. Siyang Xing, Wenyan Pan,Chang Liu, Jun Ren, Zhongwen Wang* “EfficientConstruction of Oxa- and Aza-[n.2.1] Skeletons: Lewis Acid-CatalyzedIntramolecular [3+2] Cycloaddition of Cyclopropane 1,1- Diesters with Carbonylsand Imines” Angew. Chem. Int. Ed. 2010, 49(18), 3215-3218.
7. Bao Hu, Siyang Xing, JunRen, Zhongwen Wang* “Total Synthesisof (±)-Bruguierol A via an Intramolecular [3+2] Cycloaddition of Cyclopropane1,1-Diester” Tetrahedron, 2010, 66(30), 5671-5674.
8. Linxia Li, Ding Du, Jun Ren, Zhongwen Wang* “N-Heterocyclic Carbene Catalyzed Domino Reactions ofFormylcyclopropane 1,1-Diesters: Construction of a 6-5-5Tricyclic Pyrrolo[1,2-a]indole” Eur. J. Org. Chem. 2011,(03), 614-618.
9. Siyang Xing, Yan Li, Zhen Li, Chang Liu,Jun Ren, Zhongwen Wang* “LewisAcid-Catalyzed Intramolecular Cross [3+2] Cycloaddition of Donor-Acceptor Cyclopropaneswith Carbonyls: A General Strategy for Construction of Bridge-Acetal[n.2.1]Skeletons” Angew. Chem. Int. Ed. 2011, 50(52), 12605-12609.
10. Yu Bai, Weijie Tao, Jun Ren, Zhongwen Wang* “Lewis Acid CatalyzedIntramolecular [4+2] and [3+2] Cross-Cycloaddition of AlkynylcyclopropaneKetones with Carbonyl Compounds and Imines” Angew.Chem. Int. Ed. 2012, 51(17),4112-4116.
11. ZhongwenWang* “PolarIntramolecular Cross-Cycloadditions of Cyclopropanes toward Natural ProductSynthesis” Synlett 2012, 23, 2311-2327 (Account).
12. Wenju Zhu, JieFang, Yong Liu, Jun Ren, Zhongwen Wang*“Lewis Acid Catalyzed FormalIntramolecular [3+2] Cross-Cycloaddition of Cyclopropane 1,1-Diesters withAlkenes: General and Efficient Strategy for Construction of Bridged [n.2.1]Carbocyclic Skeletons” Angew. Chem. Int.Ed.2013, 52(07), 2032-2037.
13. Zhenjun Wang, Jun Ren, Zhongwen Wang* “Lewis Acids Promoted Formal Intramolecular [3+2]Parallel and Cross-Cycloadditions of Cyclopropane 1,1-Diesters with Allenes” Org. Lett. 2013, 15(22), 5682-5685.
14. Bo Cui, Jun Ren, Zhongwen Wang* “TfOH-catalyzedFormal [3+2] Cycloaddition of Cyclopropane 1,1-Diesters with Nitriles” J. Org. Chem. 2014, 79(02), 790-796.
15. Wenju Zhu, Jun Ren, Zhongwen Wang* “Acid-Catalyzed Domino Meinwald Rearrangement ofEpoxides/Intramolecular [3+2] Cross-Cycloaddition ofCyclopropane-1,1-dicarboxylate” Eur. J.Org. Chem. 2014, 17, 3561-3564.
16. Jun Ren, JilaiBao, Weiwei Ma, Zhongwen Wang* “TandemDiels-Alder [4+2] Cycloadditions/Intramolecular [3+2] Cross-Cycloadditions ofDienylcyclopropane 1,1-diesters” Synlett 2014,25, 2260-2264.
17. Junhui Zhang, Siyang Xing, Jun Ren, Shende Jiang*, Zhongwen Wang* “Lewis Acid Catalyzed Intramolecular [3+2] CrossCycloadditions of Cobalt-Alkynylcyclopropane 1,1-diesters with Carbonyls forConstruction of Medium-sized and Polycyclic Skeletons” Org. Lett. 2015, 17(02), 218-221.
18. Weiwei Ma, Jie Fang, Jun Ren, Zhongwen Wang* “Lewis Acid CatalyzedFormal Intramolecular [3+3] Cross-Cycloaddition of Cyclopropane 1,1-Diestersfor Construction of Benzobicyclo[2.2.2]octaneSkeletons” Org. Lett. 2015, 17(17), 4180-4183.
19. Zhenjun Wang, ShuaiChen, Jun Ren, Zhongwen Wang* “CooperativePhoto-/Lewis Acid Catalyzed Tandem Intramolecular [3+2] Cross-Cycloadditions ofCyclopropane 1,1-Diesters with α, β -Unsaturated Carbonyls for Medium-SizedCarbocycles” Org. Lett. 2015, 17(17), 4184-4187.
20. Chi Zhang, Muyun Xu, Jun Ren, ZhongwenWang* “Sc(OTf)3-Catalyzed Diastereoselec tive Formal [3+2] CycloadditionReac tions of Alkynylcyclopropane Ketones with Electron-Rich Aromatic Aldehydesto Yield 2,5-trans-Tetrahydrofurans” Eur.J. Org. Chem. 2016, 2467-2478.
21. Chi Zhang, Jun Tian, JunRen, ZhongwenWang* “Intramolecular Parallel [4 + 3] Cycloadditions ofCyclopropane 1,1-Diesters with [3]Dendralenes: Efficient Construction of[5.3.0]decane and Corresponding Polycyclic Skeletons” Chem. Eur. J. 2017, 23(06), 1231-1236 (As Frontispiece).
22.Yizhou Zhan, Tao Liu, Jun Ren, ZhongwenWang* “Lewis Acid-CatalyzedIntramolecular [3+2] Cross Cycloadditions of Aziridine 2,2-Diesters withConjugated Dienes for Construction of Aza-[n.2.1] Skeletons” Chem. Eur. J. 2017, 23(71), 17862-17866 (As Frontispiece).
23. BingxiaSun, Jun Ren, Siyang Xing*, Zhongwen Wang* “Synthesis of(−)-Pyrido[3,4-b]homotropane (PHT) and (±)-PHT via an Intramolecular Cross[3+2] Cycloaddition Strategy” Adv. Synth.Catal. 2018, 360(07), 1529-1537.
24. PengcaiLiu, Yutao Cui, Kang Chen, Xinyue Zhou, Wenyan Pan, Jun Ren, Zhongwen Wang* “Total Syntheses of(−)-Englerins A/B, (+)-Orientalols E/F, and (−)-Oxyphyllol” Org.Lett. 2018, 20(09), 2517-2521.
25. Lu Chen, JunTian, Yizhou Zhan, Jun Ren, ZhongwenWang* “Lewis Acid-Catalyzed Intramolecular [3+2] Cross-Cycloaddition ofDonor-Acceptor Epoxides with Alkenes forConstruction of Oxa-[n.2.1] Skeletons” Chin.J. Chem. 2019, 37(07), 695-699. (南开百年庆典邀请稿)(AsBack Cover)
26. Bingxia Sun, Zhongwen Wang* “Syntheses andBiological Properties of PHT and Its Analogues with Bridged Aza‐[n.2.1]Skeletons” Asian J. Org. Chem. 2019,08(08), 1142-1150 (doi.org/10.1002/ajoc.201900348)(Invitedreview)
27. YiCui, Jun Ren, Jiayuan Lv, Zhongwen Wang*“Studies toward the Total Syntheses of Calyciphylline D‑Type DaphniphyllumAlkaloids” Org. Lett. 2021, 23(23), 9189-9193.
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