关英教授课题组主要从事高分子凝胶材料的研究，特别是高强度凝胶和层层自组装膜的研究。

        在高强度凝胶方面，提出了多肽增强策略，即利用α-螺旋多肽分子内氢键的断裂实现能量耗散的新的能量耗散机制增强凝胶的策略，在实现高韧性的同时获得高回复性，解决了高强度水凝胶高韧性与高回复性的矛盾。进一步地，将多肽增强策略和深共晶溶剂相结合，解决了凝胶不抗冻、不抗干、不黏附的问题；将多肽增强策略和链缠结策略相结合，解决了低固含量水凝胶力学性能差的问题。

       在层层自组装膜方面，提出了动态层层自组装膜的概念，设计制备了零级释放药物载体、延迟释放药物载体和精准程序释放药物载体，并应用于一针免疫疫苗制备。

       研究兴趣涉及弹性体、生物医用高分子材料、光子晶体与结构色材料、细胞培养、组织工程、3D打印、科普宣教等领域。欢迎热爱并追求极致，有好奇心、探索心、进取心、内驱力和执行力的多边形同学来课题组开展有意义又有趣的科研工作，一起创造美好生活。

代表性文章分类如下：

综述：

1. Guan Y, Zhang YJ. Progress in the Studyof Microgel Colloidal Crystals. ACTA POLYMERICA SINICA. 2017(11): 1739-1752.

2. Guan Y, and Zhang YJ. Boronicacid-containing hydrogels: synthesis and their applications. CHEMICAL SOCIETYREVIEWS, 2013. 42(20): 8106-8121.

3. Guan Y, and Zhang YJ. PNIPAM microgelsfor biomedical applications: from dispersed particles to 3D assemblies. SOFT MATTER,2011. 7(14): 6375-6384.

4. 关英，张拥军等, 层层自组装膜的研究:从基础到生物医学领域中的应用. 高分子通报, 2013(1): 第40-52页

延迟释放药物系统设计：

1. Wang H., et al. A highly programmableplatform for sequential release of protein therapeutics. JOURNAL OF MATERIALSCHEMISTRY B. 2021, 9(6): 1616-1624

2. Zhao Y., et al. Dynamic Layer-by-LayerFilms: A Platform for Zero-Order Release. BIOMACROMOLECULES, 2015. 16(7):2032-2039

氧化还原性水凝胶设计：

1. Hou J., et al. Enzymatically crosslinkedalginate hydrogels with improved adhesion properties. POLYMER CHEMISTRY, 2015.6(12): 2204-2213.

2. Zhang A., et al. Oxidativepolymerization of hydroquinone using deoxycholic acid supramolecular template.SCIENCE CHINA-CHEMISTRY. 2012, 55(5SI): 830-835.

3. He J., et al. Novel Redox Hydrogel by inSitu Gelation of Chitosan as a Result of Template Oxidative Polymerization ofHydroquinone. MACROMOLECULES, 2011. 44(7): 2245-2252.

光子晶体制备及应用：

1. Yao L., et al. Tetrahedral, Octahedral,and Triangular Dipyramidal Microgel Clusters with Thermosensitivity Fabricatedfrom Binary Colloidal Crystals Template and Thiol-Ene Reaction[J]. ACS MACROLETTERS. 2018, 7(1): 80-84.

2. Liu Y., et al. New polymerizedcrystalline colloidal array for glucose sensing. CHEMICAL COMMUNICATIONS,2009(14): 1867-1869.

功能化层层自组装膜设计及应用：

1. Wang R., et al. A CO2-responsivehydrogel film for optical sensing of dissolved CO2. SOFT MATTER. 2019, 15(30):6107-6115.

2. Li Q., et al. Thin hydrogel films basedon lectin-saccharide biospecific interaction for label-free optical glucosesensing. SENSORS AND ACTUATORS B-CHEMICAL. 2018, 272: 243-251.

3. Song J., et al. Growth of giant silverdendrites on layer-by-layer assembled films. POLYMER, 2015. 63: 237–243.

3D多细胞球培养：.

1. Gu J, et al. Effect of particle size ina colloidal hydrogel scaffold for 3D cell culture. COLLOIDS AND SURFACESB-BIOINTERFACES. 2015, 136: 1139-1147.

2. Zhao Z, et al. Hydrogel Thin Film withSwelling-Induced Wrinkling Patterns for High-Throughput Generation ofMulticellular Spheroids. BIOMACROMOLECULES. 2014, 15(9): 3306-3312.

授权专利：

1. 氧化还原活性聚对苯二酚微球及其制备方法，ZL201110003153.8

2. 一种持续恒速释放药物的药物载体，ZL201610115967.3

3. 多肽交联的蛋白质分子印迹聚合物及其制备方法和应用，ZL201910147938.9