多年来主持或参加国家自然科学基金、国家重点研发计划、天津市自然科学基金等多项国家级/省部级研究课题工作。

1. Lei Wang, Wenqi Fan, Na Yang, Lixia Xiong, Baolei Wang*. Novel Insecticidal Butenolide-Containing Methylxanthine Derivatives: Synthesis, Crystal Structure, Biological Activity Evaluation, DFT Calculation and Molecular Docking. Chem. Biodivers., 2024, 21: e202400823.

2. Wenqi Fan, Shuyun Zhang, Na Yang, Yonghong Li, Xiao Zhang, Congwei Niu, Xinghai Liu*, Baolei Wang*. Studies on the synthesis, crystal structures, biological activities andmolecular docking of novel natural methylxanthine derivatives containing piperazine moiety. Mol. Divers., 2024, doi: 10.1007/s11030-024-10972-z.

3. Lei Wang, Wenqi Fan, Li Cui, Na Yang, Xiao Zhang, Shujing Yu, Yonghong Li, Baolei Wang*. Synthesis and biological activity evaluation of novel chalcone analogues containinga methylxanthine moiety and their N-acylpyrazoline derivatives. J. Agric. Food Chem., 2023, 71: 19343-19356.

4. Shuyun Zhang, Lei Wang, Hang Liu, Na Yang, Shujing Yu, Baolei Wang*. Synthesis, crystalstructures, and biological activity evaluation of novel xanthine derivatives containinga pyrethroid moiety. J. Agric. Food Chem., 2022, 70: 12330-12340.

5. Shuyun Zhang, Hang Liu, Na Yang, Lixia Xiong, Baolei Wang*. Synthesis and evaluation ofnovel xanthine-acrylamides and xanthine-acrylates as insecticidal agents. Pest Manag. Sci., 2022, 78:2086-2095.

6. Huan Li, Hang Liu, Yan Zhang, Na Yang, Lixia Xiong, Zhengming Li, Baolei Wang*. Synthesis, insecticidal activities, and SAR studies of novel piperazine-containing heterocyclic mono-/di-/tri-amide derivatives. Chin. Chem. Lett., 2021, 32: 2893-2898.

7. Baolei Wang, Marius-Georgian Constantin, Simarpreet Singh, Yuqiao Zhou, Rebecca L. Davis*, F. G. West*. Generation and trapping of electron-deficient 1,2-cyclohexadienes. Unexpected hetero-Diels–Alder reactivity. Org. Biomol. Chem., 2021, 19: 399-405.

8. Yan Zhang, Junfeng Shang, Huan Li, Hang Liu, Haibin Song, Baolei Wang*, Zhengming Li*. Synthesis of novel N-pyridylpyrazole derivatives containing 1,2,4-oxadiazole moiety via 1,3-dipolar cycloaddition and their structures and biological activities. Chin. Chem. Lett., 2020, 31: 1276-1280.

9. Baolei Wang*, Hongwei Zhu, Zhengming Li, Xiao Zhang, Shujing Yu, Yi Ma, Haibin Song. One-pot synthesis, structure and structure-activity relationshipof novel bioactive diphenyl/diethyl(3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazol-5-yl)(arylamino) methylphosphonates. Pest Manag. Sci., 2019, 75: 3273-3281.

10. Bao-Lei Wang*, Hong-Wei Zhu, Zheng-Ming Li, Li-Zhong Wang, Xiao Zhang, Li-Xia Xiong, Hai-Bin Song. Synthesis, biological evaluation and SAR analysis of novel poly-heterocyclic compounds containing pyridylpyrazole group. Pest Manag. Sci., 2018, 74: 726-736.

11. Yan Zhang, Zhengming Li, Haibin Song, Baolei Wang*. Synthesis, structure and biological activities of novel 2-(trifluoromethyl)-6-arylimidazo[2,1-b][1,3,4]-thiadiazole (bis-)Mannich base derivatives containing substitutedpiperazine moiety. Chin. J. Chem., 2018, 36: 635-638.

12. Bao-Lei Wang*, Li-Yuan Zhang, Xing-Hai Liu, Yi Ma, Yan Zhang, Zheng-Ming Li*, Xiao Zhang. Synthesis, biological activities and SAR studies of new 3-substitutedphenyl-4-substitutedbenzylideneamino-1,2,4-triazole Mannich bases and bis-Mannich bases as ketol-acid reductoisomerase inhibitors. Bioorg. Med. Chem. Lett., 2017, 27: 5457-5462.

13. Bao-Lei Wang, Yan-Xia Shi, Shu-Jun Zhang, Yi Ma, Hong-Xue Wang, Li-Yuan Zhang, Wei Wei, Xing-Hai Liu, Yong-Hong Li, Zheng-Ming Li*, Bao-Ju Li*. Syntheses, biological activities and SAR studies of novel carboxamide compounds containing piperazine and arylsulfonyl moieties. Eur. J. Med. Chem., 2016, 117: 167-178.

14. Yan Zhang, Xing-Hai Liu, Yi-Zhou Zhan, Li-Yuan Zhang, Zheng-Ming Li, Yong-Hong Li, Xiao Zhang, Bao-Lei Wang*. Synthesis and biological activities of novel 5-substituted-1,3,4-oxadiazole Mannich bases and bis-Mannich bases as ketol-acid reductoisomerase inhibitors. Bioorg. Med. Chem. Lett., 2016, 26: 4661-4665.

15. Bao-Lei Wang*, Li-Yuan Zhang, Yi-Zhou Zhan, Yan Zhang, Xiao Zhang, Li-Zhong Wang, Zheng-Ming Li*. Synthesis and biological activities of novel 1,2,4-triazole thiones and bis(1,2,4-triazole thiones) containing phenylpyrazole and piperazine moieties. J. Fluorine Chem., 2016, 184: 36-44.

16. 詹益周, 王宝雷*, 张丽媛, 张燕, 张晓, 李正名*, 宋海斌. 基于Ugi反应的含芳氨基甲酰基1-氰基-1-环丙烷甲酰胺类新化合物的合成、结构和生物活性研究. 化学学报, 2015, 73: 1173-1181.

17. Bao-Lei Wang*, Qing-Nan Li, Yi-Zhou Zhan, Li-Xia Xiong, Shu-Jing Yu, Zheng-Ming Li*. The synthesis and biological activities of [5-(4-substituted phenylsulfinyl/sulfonyl)-1,3-dimethyl-1H-pyrazol-4-yl]-arylmethanones. Phosphorus Sulfur Silicon Relat. Elem., 2014, 189: 483-491.

18. Bao-Lei Wang, Hong-Wei Zhu, Yi Ma, Li-Xia Xiong, Yong-Qiang Li, Yu Zhao, Ji-Feng Zhang, You-Wei Chen, Sha Zhou, Zheng-Ming Li*. Synthesis, insecticidal activities, and SAR studies of novel pyridylpyrazole acid derivatives based on amide bridge modification of anthranilic diamide insecticides. J. Agric. Food Chem., 2013, 61: 5483-5493.

近年部分申请/授权的专利：

1. 一种含黄嘌呤-8-基的(E)-丙烯酸衍生物及其制备方法和应用. 中国发明专利, ZL202111066326.0, 申请日: 2021年09月13日, 授权日: 2022年10月25日.

2. 8-芳氧基烷氧基取代黄嘌呤衍生物及其制备方法和应用. 中国发明专利, ZL202110760621.X, 申请日: 2021年07月06日, 授权日: 2022年11月15日.

3. 一种含噻吩基吡啶和硫基团的乙酰芳胺衍生物及其制备方法和用途. 中国发明专利, ZL202110515114.X, 申请日: 2021年05月12日, 授权日: 2022年11月25日.

4. 含苯并噻唑氨基和杂芳基的萘酚衍生物与制备方法和用途. 中国发明专利, ZL202010068054.7, 申请日: 2020年1月21日, 授权日: 2022年09月23日.

5. 一种含取代磺亚胺酰基芳基的吡唑甲酰胺衍生物及其制备方法和用途. 中国发明专利, 申请号: 202010016663.8, 申请日: 2020年1月8日.

6. 含哌嗪的1,3,4-噁二唑Mannich碱类化合物及制备与应用. 中国发明专利, ZL201610039702.X, 申请日: 2016年1月20日, 授权日: 2017年9月12日.

7. 含三氟甲基和哌嗪的三唑Mannich碱类化合物及其制备与应用. 中国发明专利, ZL201510603487.7, 申请日: 2015年9月17日, 授权日: 2019年3月5日.

8. 含(杂)芳基和哌嗪的1,2,4-三唑硫酮衍生物及制备方法和应用. 中国发明专利, ZL201510603490.9, 申请日: 2015年9月17日, 授权日: 2018年5月1日.

9. 1,2,4-三唑环并[4,3-a]稠合哌嗪的曼尼希碱类衍生物及其制备方法和应用. 中国发明专利, ZL201610993675.X, 申请日: 2016年11月11日, 授权日: 2019年3月19日.