近五年学术论文

1. Application of dually activated Michael acceptor to the rational design of reversible covalent inhibitor for Enterovirus 71 3C protease. Yuying Ma, Linfeng Li, Shuai He, Chengyou Shang, Yang Sun, Ning Liu, Thomas Meek, Ya Xin Wang*,Luqing Shang*. J. Med. Chem., 2019, 62, 6146-6162.

2. An ICT-based mitochondria-targeted fluorescent probe for hydrogen peroxide with a large turn-on fluorescence signal. Xiao Liang, Lu Zhang, Xiaoyi Xu, Dan Qiao, Tangliang Shen, Zheng Yin,Luqing Shang*. ChemistrySelect, 2019, 4(4), 1330-1336.

3．4‐Iminooxazolidin-2-one as a bioisostere of the cyanohydrin moiety: inhibitors of enterovirus 71 3C protease. Yuying Ma, Chengyou Shang, Peng Yang, Linfeng Li, Yangyang Zhai, Zheng Yin, Binghe Wang*,Luqing Shang*. J. Med. Chem., 2018, 61, 22, 10333-10339.

4. A highly selective and sensitive fluorescent probe for simultaneously distinguishing and sequentially detecting H2S and various thiol species in solution and in live cells. Dan Qiao, Tangliang Shen, Mengyuan Zhu, Xiao Liang, Lu Zhang, Zheng Yin, Binghe Wang*,Luqing Shang*. Chem. Commun., 2018, 54, 13252-13255.

5. 3D-quantitative structure-activity relationship study for the design of novel。enterovirus A71 3C protease inhibitors. Quandeng Nie, Xiaoyi Xu, Qi Zhang, Yuying Ma, Zheng Yin,Luqing Shang*. Chem Biol Drug Des. 2018, 92(4), 1750-1762.

6. Target-guided screening of fragments (TGSOF) in the discovery of inhibitors against EV-A71 3C protease. Shengjun Fu, Quandeng Nie, Yuying Ma, Ping Song, Xuejiao Ren, Cheng Luo,Luqing Shang*, Zheng Yin*. Chem. Commun.,2018, 54, 2890-2893.

7. Dual mechanism ICT-FRET-based fluorescent probe for the selective detection of hydrogen peroxide. Xiao Liang, Xiaoyi Xu, Dan Qiao, Zheng Yin, Luqing Shang*. Chem-Asian J. 2017, 2017,12, 3187-3194.

8. Structure of the Enterovirus 71 3C protease in complex with NK-1.8k and indications for the development of antienterovirus protease inhibitor. Yaxin Wang, Lin Cao, Yangyang Zhai, Zheng Yin, Yuna Sun*,Luqing Shang*. Antimicrob. Agents. Chemother. 2017, 61, e00298-17.

9. Inhibition of enterovirus 71 replication by ana-hydroxy-nitrile derivative NK-1.9k. Yaxin Wang, Lin Cao, Yangyang Zhai, Jiaming Ma, Quandeng Nie, Ting Li, Zheng Yin, Yuna Sun*,Luqing Shang*. Antiviral Res. 2017, 141, 91-100.

10. Discovery of 2’-a-C-Methyl-2’-b-C-fluorouridine phosphoramidate prodrugs as inhibitors of Hepatitis C virus. Debin Zeng, Rui Zhang, Quandeng Nie, Lin Cao,Luqing Shang*, Zheng Yin* ACS Med. Chem. Lett. 2016, 7 (12), 1197-1201

11. Structure activity relationship study of peptidomimetic aldehydes as enterovirus 71 3C protease inhibitors. Yangyang Zhai, Yuying Ma, Fei Ma, Quandeng Nie, Xuejiao Ren, Yaxin Wang,Luqing Shang*, Zheng Yin*. Eur. J. Med. Chem. 2016, 124: 559-573.

12. A 3,7-dihydroxyphenoxazine-based fluorescent probe for selective detection of intracellular hydrogen peroxide. Zhiqiang Han Xiao Liang, Xuejiao RenLuqing Shang*, Zheng Yin*. Chem-Asian J. 2016, 11: 818-822.

13. Synthesis and structure–activity relationship of α-keto amides as enterovirus 71 3C protease inhibitors. Debin Zeng, Yuying Ma, Rui Zhang, Quandeng Nie, Zhengjie Cui, Yaxin Wang,Luqing Shang*, Zheng Yin*. Bioorg.Med.Chem. Lett., 2016, 26 (7):1762-1766.

14. The discovery of indole derivatives as novel hepatitis C virus inhibitors.Zhiqiang Han, Xiao Liang, Yaxin Wang, Jie Qing, Lin Cao,Luqing Shang*, Zheng Yin*. Euro. J. Med. Chem., 2016, 116: 147-155.

15. Cyanohydrin as an anchoring group for potent and selective inhibitors of Enterovirus 71 3C protease. Yangyang Zhai, Xiangshuai Zhao, Zhengjie Cui, Man Wang, Yaxin Wang, Linfeng Li, Qi Sun, Xi Yang, Debing Zeng, Ying Liu, Yuna Sun, Zhiyong Lou,Luqing Shang*, Zheng Yin*, J. Med. Chem., 2015,58,941-9420.

16. Site-specific chemical modification of peptide and protein by thiazolidinediones. Peng Wang,Shumei Zhang,Qiuyue Meng,Ying Liu,Luqing Shang*, andZheng Yin*,Org. Lett., 2015, 17 (6), 1361–1364.

17. Biochemical characterization of recombinant Enterovirus 71 3C protease with fluorogenic model peptide substrates and development of a biochemical assay.Luqing Shang, Shumei Zhang, Xi Yang, Jixue Sun, Linfeng Li, Zhengjie Cui, Qiuhong He, Yu Guo, Yuna Sun*, Zheng Yin*, Antimicrob. Agents. Chemother., 2015 Apr; 59(4):1827-1836.

授权专利情况：

1.尚鲁庆,娄智勇，王亚鑫，饶子和等。核苷类化合物在制备治疗肠病毒71（EV71）感染疾病药物的应用。专利号：ZL. 201010613121.5。

2.尚鲁庆,赵向帅，娄智勇，王亚鑫，徐梦莹，王朋，崔璨璨，陈成，赵强，周红刚，饶子和等。抗肠病毒71（EV71）己内酰胺醛类化合物及其制备方法和用途。专利号：ZL.201110384897.9。

3.尚鲁庆,赵向帅，娄智勇，王亚鑫，徐梦莹，王朋，崔璨璨，陈成，赵强，周红刚，饶子和等。抗肠病毒71（EV71）己内酰胺类化合物及其制备方法和用途。专利号：ZL201110402922.1。

4.尚鲁庆，王朋，张雪，李林锋等。石蒜碱类化合物在制备抗肿瘤药物的应用。专利号：ZL. 201210063482.6。

5.张雪，尚鲁庆，崔璨璨等。抗登革热病毒（DENV）杂环肽类化合物及其制备方法和用途。专利号：ZL. 201210144172.7。