刘丽课题组主要从事功能高分子和生物医用高分子合成及应用的研究。研究工作集中在蛋白质-聚合物生物缀合物、蛋白质杂化组装体和无机/聚合物组装体的构筑及应用方面。围绕组装体的形貌与尺度控制、材料的表面结构与性能调控等关键科学问题，采用可控自由基聚合技术结合高效偶联化学对聚合物的分子结构进行设计和合成，构建具有环境刺激响应性和动态性的蛋白质杂化纳米材料并应用于药物递送领域；通过表面共组装的方法实现对材料的表面结构和性能的调控，构筑具有智能表面的无机/有机复合纳米材料。作为项目负责人已主持6项国家自然科学基金项目和1项天津市自然科学基金项目。

代表性研究论文：

(1) Xue Kang, Mengyang Yu, Hanying Zhao,Li Liu,* Pyridinyl Polythioether via a One-PotThiolactone Ring-Opening and Thiol-Phenylsulfone Click Polymerization:Synthesis, Fluorescence, and Degradation Behavior, Macromolecules, 2025. https://doi.org/10.1021/acs.macromol.4c02963

(2)Yupeng Liu, Hanying Zhao, Li Liu,*Redox Dual-Responsive Diaryl Ditelluride-Containing Nanoparticles as PeroxidaseMimetics, Eur. Polym. J. 2024, 212, 113048.

(3) Lun Wang, Li Liu,* Hanying Zhao,* Synthesisof Cleavable Polymers via Oxidation of Thioether Moieties and Thiol ClickReactions: A Click-Declick Strategy, Angew.Chem. Int. Ed. 2023, 62, e202304073.

(4) Shuqi Dong, Yanfen Jiang, Guoyang Qin,Li Liu,* Hanying Zhao, Methionine-Based pH and Oxidation Dual-Responsive BlockCopolymer: Synthesis and Fabrication of Protein Nanogels, Biomacromolecules, 2020,21, 4063-4075.

(5) Lin Wang, Li Liu,* Bingyang Dong,Hanying Zhao, Peroxidase-Mediated In Situ Fabrication ofMulti-Stimuli-Responsive and Dynamic Protein Nanogels from Tyrosine-ConjugatedBiodynamer and Ovablumin, ACS MacroLett., 2019, 8, 1233-1239.

(6) Ya Zhao Li Liu* Hanying Zhao* SurfaceReconstruction by a Coassembly Approach, Angew.Chem. Int. Ed. 2019, 58 10577-10581.

(7) Bingyang Dong, Li Liu,* Cong Hu, ATP-DrivenTemporal Control over Structure Switching of Polymeric Micelles, Biomacromolecules, 2018, 19, 3659-3668.

(8) Lin Wang, Li Liu,*Bingyang Dong, Hanying Zhao, Mingming Zhang, Wenjuan Chen, Yanhang Hong,Multi-stimuli-responsive biohybrid nanoparticles with cross-linked albumincoronae self-assembled by a polymer-protein biodynamer, Acta Biomaterialia, 2017,54, 259-270.