基于抗癌天然产物的结构改造和新药发现

发表论文

1.        Zhang, H.; Xie, F.; Yuan, X.-y.; Dai, X.-t.; Tian, Y.-f.; Sun, M.-m.; Yu,S.-q.; Cai, J.-y.; Sun, B.; Zhang,W.-c.; Shan, C.-l. Discovery of a nitroaromatic nannocystin with potentin vivo anticancer activity against colorectal cancer by targeting AKT1. Acta Pharmacol. Sin. 2024, published online, doi:10.1038/s41401-024-01231-w.

2.        Zhang, H.; Cai, J.; Yu, S.; Sun, B.; Zhang, W. Anticancer Small-Molecule Agents TargetingEukaryotic Elongation Factor 1A: State of the Art. Int. J. Mol. Sci. 2023, 24, 5184

3.        Cai, J.; Sun, B.; Yu, S.; Zhang, H.; Zhang, W. Heck Macrocyclization in Forging Non-Natural LargeRings including Macrocyclic Drugs. Int.J. Mol. Sci. 2023, 24, 8252.

4.        Zhang, H.; Tian, Y.; Yuan, X.; Xie, F.; Yu, S.; Cai, J.; Sun,B.; Shan, C.; Zhang, W.Site-directed Late-Stage Diversification of Macrocyclic NannocystinsFacilitating Anticancer SAR and Mode of Action Studies. RSC Med. Chem. 2023, 14, 299-312.

5.        Zhang, W. Heck macrocyclization innatural product total synthesis. Nat.Prod. Rep. 2021, 38, 1109-1135.

6.        Zhang, W. From Target-Oriented toMotif-Oriented: A Case Study on Nannocystin Total Synthesis. Molecules 2020, 25, 5327.

7.       Tian, Y.; Wang, J.; Liu, W.;Yuan, X.; Tang, Y.; Li, J.; Chen, Y.; Zhang,W. Stereodivergent total synthesis of Br-nannocystins underpinning thepolyketide (10R,11S) configuration as a key determinant ofpotency. J. Mol. Struct. 2019, 1181, 568-578.

8.        Tian, Y.; Ding, Y.; Xu, X.; Bai, Y.; Tang, Y.; Hao, X.; Zhang, W.; Chen, Y. Totalsynthesis and biological evaluation of nannocystin analogues modified at thepolyketide phenyl moiety. TetrahedronLett. 2018, 59, 3206-3209.

9.        Tian, Y.; Xu, X.; Ding, Y.; Hao, X.; Bai, Y.; Tang, Y.;Zhang, X.; Li, Q.; Yang, Z.; Zhang,W.; Chen, Y. Synthesis and biological evaluation of nannocystinanalogues toward understanding the binding role of the (2R,3S)-Epoxide innannocystin A. Eur. J. Med. Chem. 2018, 150, 626-632.

发明专利

1.        张炜程; 陈悦; 田云锋. 大环nannocystin衍生物、及其制备方法和用途. CN201910234635.0, 2019.

2.        张炜程; 袁小雅. 氮取代大环nannocystin类似物、及其制备方法和用途. 202110256141.X, 2021.