(1) 河北省科学技术厅, 河北省重点研发计划项目, 22326411D, 新型天然芳香基高碳护土保水有机肥的研制, 2022-07 至 2025-06, 30万元, 在研, 参与

(2) 黄河科技学院, 横向项目, 无, 基于分子对接从天然产物中虚拟筛选抗糖尿病先导化合物, 2023-09 至 2025-05, 5.05万元, 在研, 主持

(3) 天津市科学技术局, 天津市应用基础研究自主立项校内合作项目, 21JCYBJC00290, 以RUNX1复苏和RUNX1-ETO基因沉默为基础的高精准靶向寡核苷酸药物治疗急性髓系白血病的研究, 2021-10 至 2024-09, 10万元, 结题, 参与

(4) 天津市自然科学基金委员会，青年项目，14JCQNJC06100，细胞色素P450eryF Comound I形成机理的理论研究，2014-04至2017-03，6万元，已结题，主持

(5) 教育部，高等学校博士学科点专项科研基金（新教师类），20120031120052，氟脒抑制肽酰基精氨酸脱亚胺酶4（PAD4）机理的理论研究，2013/01至2015/12，5万元，已结题，主持

(6) 国家自然科学基金委员会，青年科学基金项目，21203101，基于反应机理的肽酰基精氨酸脱亚胺酶4（PAD4）抑制剂的虚拟筛选，2013-01-2015-12，22万元，已结题，主持

1. Xuhang Lu#,Dongmei Li#, Yaojie Wang#, Gaohua Zhang#,Tianlei Wen, Yue Lu, Nan Jia, Xuedi Wang, Shenghai Chang, Xing Zhang, JianpingLin*, Yu-hang Chen*, Xue Yang*, Yuequan Shen*, Structural insights into theactivation mechanism of the human zinc-activated channel, Nature Communications, 2025, 16: 442.

2. Can Peng, Xinyue Lv,Zhiqiang Zhang, Jianping Lin*, Dongmei Li*, The recognition pathway ofthe SARS-CoV-2 spike receptor-binding domain to human angiotensin-converting enzyme2, Molecules, 2024, 29: 1875.

3. Kaili Zhao, Fukai Xie,Dongmei Li*, Shuang Gao*, A Mn(II)-catalyzed tandem oxidative cleavageand ammoxidation of alcohols to primary amides, Synlett, 2023, 34: 1814-1818.

4. Yang Li#,Jixue Sun#, Dongmei Li*, Jianping Lin*, The full activationmechanism of the adenosine A1 receptor revealed by GaMD and Su-GaMDsimulations, Proceedings of the National Academy of Sciences, 2022,119(42): e2203702119.

5. Ting Xiao#,Mengqi Cui#, Caijuan Zheng#, Peipei Zhang#,Shanfa Ren, Jiali Bao, Dandi Gao, Ronghao Sun, Ming Wang, Jianping Lin, LiangZhang, Mingjiang Li, Dongmei Li*,Honggang Zhou*, Cheng Yang*, Both baicalein and gallocatechin gallate effectivelyinhibit SARS‑CoV‑2 replication by targeting Mpro and sepsisin mice, Inflammation, 2022, 45: 1076-1088.

6.Mukuo Wang, Shujing Hou, Yu Wei*, DongmeiLi*, Jianping Lin*, Discovery of novel dual adenosine A1/A2Areceptor antagonists using deep learning, pharmacophore modeling and moleculardocking, PLoS Computational Biology, 2021, 17(3): e1008821.

7. Mukuo Wang, Shujing Hou, Ye Liu, Dongmei Li*, JianpingLin*, Identification of novel antagonists targeting cannabinoid receptor 2using a multi-step virtual screening strategy, Molecules, 2021, 26: 6679.

8. Ting Xiao#,Mengqi Cui#, Caijuan Zheng#, Ming Wang#,Ronghao Sun#, Dandi Gao, Jiali Bao, Shanfa Ren, Bo Yang, JianpingLin, Xiaoping Li, Dongmei Li*, ChengYang*; Honggang Zhou*, Myricetin inhibits SARS-CoV-2 viral replication bytargeting Mpro and ameliorates pulmonary inflammation, Frontiers in Pharmacology, 2021, 12: 669642.

9. Ting Xiao#,Yuli Wei#, Mengqi Cui#, Xiaohe Li#, Hao Ruan#,Liang Zhang, Jiali Bao, Shanfa Ren, Dandi Gao, Ming Wang, Ronghao Sun,Mingjiang Li, Jianping Lin, Dongmei Li*,Cheng Yang*, Honggang Zhou*, Effect of dihydromyricetin on SARS-CoV-2 viralreplication and pulmonary inflammation and fibrosis, Phytomedicine, 2021, 91: 153704.

10. Hao Wang, Shuai He,Weilong Deng, Ying Zhang, Guobang Li, Jixue Sun, Wei Zhao, Yu Guo, Zheng Yin, Dongmei Li*, Luqing Shang*,Comprehensive insights into the catalytic mechanism of middle east respiratorysyndrome 3C-like protease and severe acute respiratory syndrome 3C-likeprotease, ACS Catalysis, 2020, 10(10): 5871-5890.

11. Yu Wei#,Mukuo Wang#, Yang Li#, Zhangyong Hong, Dongmei Li*, Jianping Lin*,Identification of new potent A1 adenosine receptor antagonists usinga multistage virtual screening approach, European Journal of Medicinal Chemistry, 2020, 187: 111936.

12. Yang Li, Mukuo Wang,Na Gao, Dongmei Li*, Jianping Lin*,The effect of dimerization on the activation and conformational dynamics ofadenosine A1 receptor, PhysicalChemistry Chemical Physics, 2019, 21(41): 22763-22773.

13. Yang Li#, Can Yin#, Pi Liu#, Dongmei Li*, Jianping Lin*, Identificationof a different agonist-binding site and activation mechanism of the human P2Y1receptor, Scientific Reports, 2017, 7: 13764.

14. Weilong Zhong#, Pi Liu#, Qiang Zhang, Dongmei Li*, Jianping Lin*,Structure-based QSAR, molecule design and bioassays of protease-activatedreceptor 1 inhibitors, Journalof Biomolecular Structure & Dynamics, 2017, 35(13): 2853-2867.

15. Yu Wei#, Ruihua Liu#, Cui Liu#, Jin Jin*, Dongmei Li*, Jianping Lin*, Identification of novel PAD4 inhibitorsbased on a pharmacophore model derived from transition state coordinates, Journal of Molecular Graphics and Modelling, 2017, 72: 88-95.

16. Yang Li, Jixue Sun, Dongmei Li*, JianpingLin*, Activation and conformational dynamics of a class B G-protein-coupledglucagon receptor, Physical Chemistry Chemical Physics, 2016, 18: 12642-12650.

17.  Pi Liu, Zhonghua Wang,Lijie Zhang, Dongmei Li*, JianpingLin*, The mechanism by which 146-N-glycan affects the active site ofneuraminidase, PLoS ONE 2015, 10: e0135487.

18. Junli Xu#, ZhonghuaWang#, Pi Liu*, Dongmei Li*,Jianping Lin*, An insight into antagonist binding and induced conformational dynamics of class B GPCR corticotropin-releasing factor receptor 1, Molecular BioSystems, 2015, 11: 2042-2050.

19. Zichen Xu, Lei Zhang*, Dongmei Li*, Xiyun Liu, Yuxia Wang,Jianping Lin, Binding of a Dy(III) complex to apoferritin inhibits ironmineralization, Polyhedron, 2015, 92: 37-40.

20.  Dongmei Li*, Cui Liu, Jianping Lin*, Theoretical study of themechanism of protein arginine deiminase 4 (PAD4) inhibition by F-amidine, Journal of Molecular Graphics and Modelling, 2015, 55: 25-32.

21.  Dongmei Li*, Xiaoqin Huang, Jianping Lin, Chang-Guo Zhan*,Catalytic mechanism of cytochrome P450 for N-methylhydroxylation of nicotine:reaction pathways and regioselectivity of the enzymatic nicotine oxidation, Dalton Transactions, 2013, 42: 3812-3820.

22. Hui Ye#, Ruihua Liu#,Dongmei Li#, Yonghui Liu,Haixin Yuan, Weikang Guo, Lifei Zhou, Xuefeng Cao, Hongqi Tian, Jie Shen*, PengGeorge Wang*, A safe and facile route to imidazole-1-sulfonyl azide as adiazotransfer reagent, Organic Letters, 2013, 15: 18-21.

23. Dongmei Li, Yong Wang, Keli Han*, Recent density functional theorymodel calculations of drug metabolism by cytochrome P450, Coordination Chemistry Reviews, 2012, 256: 1137-1150.

24. Dongmei Li, Xiaoqin Huang, Keli Han, Chang-Guo Zhan*, Catalyticmechanism of cytochrome P450 for 5’-hydroxylation of nicotine: fundamentalreaction pathways and stereoselectivity, Journal of the American Chemical Society, 2011, 133: 7416-7427.

25.  Dongmei Li, Yong Wang, Keli Han*, Chang-Guo Zhan*, Fundamentalreaction pathways for cytochrome P450-catalyzed 5’-hydroxylation andN-demethylation of nicotine, The Journalof Physical Chemistry B, 2010, 114: 9023-9030.

26. Dongmei Li, Yong Wang, Chuanlu Yang, Keli Han*, Theoretical studyof N-dealkylation of N-cyclopropyl-N-methylaniline catalyzed by cytochromeP450: insight into the origin of the regioselectivity, Dalton Transactions, 2009, 291-297.