1. 国家自然科学基金面上项目 （2021-2024）线粒体靶向纳米酶介导的心脏缺血再灌注损伤的治疗研究 主持

2. 南开大学2021年度基本科研项目 纳米酶细胞器定位转换及在再灌注损伤治疗中的应用

3. 国家重大研究计划培育项目（2020-2022）三阴性乳腺癌代谢标志物筛选、鉴定及蛋白质靶向探针可视化研究 参加

4. 南开大学2020年度基本科研项目 线粒体转运蛋白CHCHD4介导线粒体自噬机制研究

1. 国家自然科学基金面上项目 （2021-2024）线粒体靶向纳米酶介导的心脏缺血再灌注损伤的治疗研究 主持

2. 南开大学2021年度基本科研项目 纳米酶细胞器定位转换及在再灌注损伤治疗中的应用

3. 国家重大研究计划培育项目（2020-2022）三阴性乳腺癌代谢标志物筛选、鉴定及蛋白质靶向探针可视化研究 参加

4. 南开大学2020年度基本科研项目 线粒体转运蛋白CHCHD4介导线粒体自噬机制研究

第一或通讯作者论文

1) Zhang, Y,Khalique, A, Du X, Gao Z, Wu J, Zhang X, Zhang R, Sun Z, Liu Q, Xu, Z, Midgley,AC,Wang L, Yan, X, Zhuang, J*, Kong, D*, Huang, X*. Biomimetic Design ofMitochondria-Targeted Hybrid Nanozymes as Superoxide Scavengers. Adv Mater. 2021:e2006570 (Co-corresponding author)

2) Sun, Z, Zhang, H, Wu, J, Gao, F, Zhang, C, Hu,X, Liu, Q, Wei, Y, Zhuang, J*,Huang, X*. A Novel Model System for Understanding Anticancer Activity ofHypoxia-Activated Prodrugs. Mol. Pharmaceutics. 2020, 17(6):2072-2082 (Co-corresponding author)

3) Huang, X*, Zhuang,J*, Chung, SW*, Halpert, G,Negron, K, Huang, B, Hwang, PM, Hanes, J, Suk, JS. Hypoxia-tropic ProteinNanocages for Modulation of Tumor- and Chemotherapy-associated Hypoxia. ACSNano. 2019, 13: 236–247 (Co-firstauthor)

4) Zhuang, J, Kamp W, Li, J, Liu, C, Kang,J, Wang, P, Hwang, PM. FOXO3 and CHCHD4 regulate p53 nuclear activity inresponse to exercise. The Journal of Biological Chemistry. 2016,291: 24819-24827.

5) Zhuang, J, Wang, P, Huang, X, Chen, X,Kang, J, Hwang, PM. Mitochondrial disulfide relay mediatestranslocation of p53 and partitions its subcellular activity. Proc Natl AcadSci U S A. 2013, 110: 17356-17361. (Recommended by Faculty of 1000)

6) Zhuang,J, Ma, W, Lago, CU, Hwang, PM. Metabolic regulation of oxygen and redoxhomeostasis by p53: Lessons from evolutionary biology? Free Radical Biologyand Medicine. 2012, 53: 1279-1285.

7) Zhuang,J, Fan, K, Gao, L, Lu, D, Feng, J, Yang, D, Gu, N, Zhang, Y, Liang, M, Yan,X. Ex Vivo Detection of Iron Oxide Magnetic Nanoparticles in Mice Using TheirIntrinsic Peroxidase-Mimicking Activity. Mol. Pharmaceutics. 2012, 9:1983-1989.

8) Zhuang,J, Jiang, T, Lu, D, Luo, Y, Zheng, C, Feng, J, Yang, D, Chen, C, Yan, X.NADPH oxidase 4 mediates reactive oxygen species induction of CD146dimerization in VEGF signal transduction. Free Radical Biology and Medicine.2010, 49: 227-236.

9) Zhuang,J, Cheng, T, Gao, L, Luo, Y, Ren, Q, Lu, D, Tang, F, Ren, X, Yang, D, Feng,J, Zhu, J, Yan, X. Silica coating magnetic nanoparticle-based silverenhancement immunoassay for rapid electrical detection of ricin toxin. Toxicon.2010, 5: 145-152.

10) Zhuang,J, Zhang, J, Gao, L, Zhang, Y, Gu, N, Feng, J, Yang, D, Yan, X. A novelapplication of iron oxide nanoparticles for detection of hydrogen peroxide inacid rain. Materials Letters. 2008, 62: 3972-3974.

11) Gao, L*, Zhuang, J*, Nie, L, Zhang, J, Zhang Y, Gu, N, Wang, T, Feng, J,Yang, D, Perrett, S, Yan, X. Intrinsic peroxidase-like activity offerromagnetic nanoparticles. Nature Nanotechnology. 2007, 2: 577-583. (Co-first author, highly cited paper)

其他论文

1) Cao, H, Cheng, Y, Gao, H, Zhuang, J, Zhang, W, Bian, Q, Wang, F, Du, Y, Li, Z, Kong, D, Ding,D, Wang Y. In Vivo Tracking of Mesenchymal Stem Cell-Derived ExtracellularVesicles Improving Mitochondrial Function in Renal Ischemia-Reperfusion Injury.ACS Nano. 2020, 14(4): 4014-4026.

2) Zhang R, Luo W, Zhang Y, Zhu D, Midgley AC, SongH, Khalique A, Zhang H, Zhuang, J,Kong D, Huang, X. Particle-based artificial three-dimensional stem cellspheroids for revascularization of ischemic diseases. Sci. Adv. 2020, 6:eaaz8011

3) Baumer, Y, Dey, AK, Gutierrez-Huerta, CA,Khalil, NO, Sekine, Y, Sanda, GE, Zhuang, J, Saxena, A, Stempinski, E,Elnabawi, YA, Dagur, PK, Ng, Q, Teague, HL, Keel, A, Rodante JA, Boisvert, WA,Tsoi, LC, Gudjonsson, JE, Bleck, CKE, Chen, MY, Bluemke, DA, Gelfand, JM, Schwartz, DM, Kruth, HS,  Powell-Wiley, TM, Playford, MP, Mehta, NN.Hyperlipidaemia and IFNgamma/TNFalpha Synergism are associated with cholesterolcrystal formation in Endothelial cells partly through modulation of LysosomalpH and Cholesterol homeostasis. EBioMedicine. 2020, 59:102876.

4) Li, J,Wang, P, Long, NA, Zhuang, J,Springer, DA, Zou, J, Lin, Y, Bleck, CKE, Park, J, Kang, J, Hwang, PM. P53prevents doxorubicin cardiotoxicity independently of its prototypical tumorsuppressor activities. Proc Natl Acad Sci U S A. 2019, 116: 19626-19634

5) Park, J, Li, J, Starost, MF, Liu, C, Zhuang, J, Chen, J, Achatz, MI, Kang,J, Wang, P, Savage, SA, Hwang, PM. Mouse homolog of the human TP53 R337Hmutation reveals its role in tumorigenesis. Cancer Research. 2018, 78: 5375-5383.

6) Huang,X, Chisholm, J, Zhuang, J, Xiao, Y, Duncan G, Chen X, Suk JS, Hanes J.Protein nanocages that penetrate airway mucus and tumor tissue. Proc NatlAcad Sci U S A. 2017,114: E6595-E6602

7) Wang,P, Li, J, Walcott, F, Kang, J, Starost, M, Talagala, SL, Zhuang J, Park, J, Huffstutler, R, Bryla, C, Mai, P, Pollak, M,Annunziat, C, Savage, S, Fojo, A, Hwang, PM. Inhibiting mitochondrialrespiration prevents cancer in a mouse model of Li-Fraumeni syndrome. Journal of Clinical Investigation. 2017,127: 132-136.

8) Park,J, Zhuang J, Li J, Hwang, PM. p53 asguardian of the mitochondrial genome. FEBS Letters. 2016, 590: 924–934.

9) Wang,P, Ma, W, Park, J, Celi, FS, Arena, R, Choi, JW, Ali, QA, Tripodi, DJ, Zhuang, J, Lago, CU, Strong, LC,Talagala, SL, Balaban, RS, Kang, J, Hwang, PM. Increased Oxidative Metabolismin the Li–Fraumeni Syndrome. New England Journal of Medicine. 2013, 368:1027-1032.

10) Wang, P, Zhuang, J, Hwang, PM. p53: exercise capacity and metabolism.Curr Opin Oncol. 2012, 24:76-82.

11) Jiang, T, Zhuang, J, Duan, H, Luo, Y, Zeng, Q, Fan, K, Yan, H, Lu, D, Ye, Z,Hao, J, Feng, J, Yang, D, Yan, X. CD146 is a co-receptor for VEGFR-2 in tumorangiogenesis. Blood. 2012, 120: 2330-2339.

12) Luo, Y, Zheng, C, Zhang, J, Lu, D, Zhuang, J, Xing, S, Feng, J, Yang, D,Yan, X. Recognition of CD146 as an ERM-binding protein offers novel mechanismsfor melanoma cell migration. Oncogene. 2012, 31: 306–321.

13) Niu, Y, Zhuang, J, Liu, L, Yan, X, Jin, G. Two kinds of anti-ricin antibodyand ricin interaction evaluated by biosensor based on imaging ellipsometry. ThinSolid Films. 2011, 519: 2768-2771.

14) Mu, B, Huang, X, Bu, P, Zhuang, J, Cheng, Z, Feng, J, Yang, D,Dong, C, Zhang, J, Yan, X. Influenza virus detection with pentabody-activatednanoparticles. Journal of Virological Methods. 2010, 169: 282-289.

15) Huang, X, Zhuang, J, Teng, X, Li, L, Chen, D, Yan, X, Tang, F. The promotionof human malignant melanoma growth by mesoporous silica nanoparticles throughdecreased reactive oxygen species. Biomaterials. 2010, 31:6142-6153.

16) Huang, X, Zhuang, J, Chen, D, Liu, H, Tang, F, Yan, X, Meng, X, Zhang, L,Ren, J. General strategy for designing functionalized magnetic microspheres fordifferent bioapplications. Langmuir. 2009, 25: 11657-11663.

17) Zhang, J, Zhuang, J, Gao, L, Zhang, Y, Gu, N, Feng, J, Yang, D, Zhu, J, Yan,X. Decomposing phenol by the hidden talent of ferromagnetic nanoparticles. Chemosphere.2008, 73: 1524-1528.

18) Wang, L, Li, P, Zhuang J, Bai, F, Feng, J, Yan, X, Li, Y. Carboxylic acid enrichednanospheres of semiconductor nanorods for cell imaging. Angew Chem Int EdEngl. 2008, 47: 1054-1057.

19) Bu, P, Zhuang,J, Feng, J, Yang, D, Shen, X, Yan, X. Visualization of CD146 dimerizationand its regulation in living cells. Biochimica et Biophysica Acta (BBA)-Molecular Cell Research. 2007, 773: 513-520.

20) Bu, P, Gao, L, Zhuang, J, Feng, J, Yang, D, Yan, X. Anti-CD146 monoclonal antibodyAA98 inhibits angiogenesis via suppression of nuclear factor-B activation. MolecularCancer Therapeutics. 2006, 5: 2872-2878.