1. 国家自然科学基金面上项目，课题编号：81773120，“肿瘤干细胞外泌体Tetraspanin分子调节腺癌转移机制研究”，起止日期：2018/01-2021/12，55万元，在研，主持。

2. 天津市自然科学基金一般项目，课题编号：16JCYBJC43200，“胰腺癌早期诊断的分子标签研究”，起止日期：2016/09-2019/08，10万元，已结题，主持。

3. 德国研究基金会DFG的Zo-40/12-1/2课题支持的肿瘤细胞外泌体的组成及其在肿瘤转移中的功能研究项目

4. 德国Wilhelm Sander基金会和NCT基金支持的胰腺癌细胞转移和侵染的分子机制研究项

近5年发表论文

1. Yuan W, Lu L, Rao M, Huang Y, Liu CE, Liu S, Zhao Y, Liu H, Zhu J, Chao T, Wu C, Ren J, Lv L, Li W, Qi S, Liang Y, Yue S, Gao J, Zhang Z, Kong E. GFAP hyperpalmitoylation exacerbates astrogliosis and neurodegenerative pathology in PPT1-deficient mice. Proc Natl Acad Sci U S A. 2021 Mar 30;118(13):e2022261118.

2. Ianni A, Kumari P, Tarighi S, Simonet NG, Popescu D, Guenther S, Hölper S, Schmidt A, Smolka C, Yue S, Krüger M, Fiorillo C, Vaquero A, Bober E, Braun T. SIRT7-dependent deacetylation of NPM promotes p53 stabilization following UV-induced genotoxic stress. Proc Natl Acad Sci U S A. 2021 Feb 2;118(5):e2015339118.

3. Chen C, Wang D, Yu Y, Zhao T, Min N, Wu Y, Kang L, Zhao Y, Du L, Zhang M, Gong J, Zhang Z, Zhang Y, Mi X, Yue S, Tan X. Legumain promotes tubular ferroptosis by facilitating chaperone-mediated autophagy of GPX4 in AKI. Cell Death Dis. 2021 Jan 11;12(1):65.

4. Liu S#, Wang H#, Li J, Zhang J, Wu J, Li Y, Piao Y, Pan L, Xiang R*, Yue S*. FZR1 as a novel biomarker for breast cancer neoadjuvant chemotherapy prediction. Cell Death Dis. 2020 Sep 25;11(9):804.

5. Li J, Xu J, Li L, Ianni A, Kumari P, Liu S, Sun P, Braun T, Tan X, Xiang R*, Yue S*. MGAT3-mediated glycosylation of tetraspanin CD82 at asparagine 157 suppresses ovarian cancer metastasis by inhibiting the integrin signaling pathway. Theranostics. 2020 May 16;10(14):6467-6482.

6. Shen L, Kang L, Wang D, Xun J, Chen C, Du L, Zhang M, Gong J, Mi X, Yue S, Zhang Y, Song X, Xiang R, Zhang Z, Tan X. Legumain-deficient macrophages promote senescence of tumor cells by sustaining JAK1/STAT1 activation. Cancer Lett. 2020 Mar 1;472:40-49.

7. Liu S, Li J, Wang T, Xu J, Liu Z, Wang H, Wei GH, Ianni A, Braun T, Yue S*. Illumination of cell cycle progression by multi-fluorescent sensing system. Cell Cycle. 2019 Jun;18(12):1364-1378.

8. Kumari P, Popescu D, Yue S, Bober E, Ianni A, Braun T. Sirt7 inhibits Sirt1-mediated activation of Suv39h1. Cell Cycle. 2018;17(12):1403-1412.

9. Zhao K, Erb U, Hackert T, Zöller M*, Yue S*. Distorted leukocyte migration, angiogenesis, wound repair and metastasis in Tspan8 and Tspan8/CD151 double knockout mice indicate complementary activities of Tspan8 and CD51. Biochim Biophys Acta Mol Cell Res. 2018 Feb;1865(2):379-391.

10. Lu J, Li J, Liu S, Wang T, Ianni A, Bober E, Braun T, Xiang R*, Yue S*. Exosomal tetraspanins mediate cancer metastasis by altering host microenvironment. Oncotarget. 2017 Jul 10;8(37):62803-62815.

11. Yue S, Zhao K, Erb U, Rana S, Zöller M. Joint features and complementarities of Tspan8 and CD151 revealed in knockdown and knockout models. Biochem Soc Trans. 2017 Apr 15;45(2):437-447.