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个人概况：
日本东京大学博士，曾先后在美国密歇根大学任博士后、研究员、研究调查员，伊利诺伊大学任助理研究教授。2020年受聘为南开大学教授，主要从事巨胞饮与PI3K-mTORC1通路间相互关系以及内质网相关降解功能等方面研究。以第一作者/通讯作者在Science、JCI、JCB、EMBOJ.等多个著名学术期刊共发表文章12篇。
研究方向：
1.细胞膜运输及信号转导的作用和机制；
2.肿瘤细胞中巨胞饮和mTORC1通路的相互作用；
3.肾脏足细胞和上皮细胞中的巨胞饮功能与疾病的关系。
招生方向：细胞信号转导与疾病
Yoshida S., et al.,
Endoplasmicreticulum-associated degradation is required for nephrin maturation and kidney glomerular filtration function.
Journal of clinical investigation.Online.PMID: 33591954 (2021).
Co-corresponding.
Swanson JA and Yoshida S.Macropinosomes as units of signal transduction.
Philosophical transactions of the Royal Society B. 374: 20180157 (2019).
Co-corresponding.
Yoshida S., et al.,
Macropinocytosis,mTORC1 and cellular growth control.
Cellular and MolecularLife Sciences.75, 1227-1239 (2018a).
Yoshida S., et al.,
Dorsal RufflesEnhance Activation of Akt by Growth Factors.
Journal of Cell Science. 131, jcs220517 (2018b).
Co-corresponding.
Pacitto R, Gaeta I,Swanson JA, and YoshidaS.CXCL12-induced macropinocytosis modulates two distinct pathways to activatemTORC1 in macrophages.
Journal of Leukocyte Biology.101: jlb. 2A0316-141RR (2017).
Corresponding.
Yoshida S., et al.,
Differential signaling during macropinocytosis in response to M-CSF and PMA in macrophages.
Frontiers in physiology.6, 8 (2015a).
Yoshida S., et al.,
Growth factor signaling to mTORC1 by amino acid-laden macropinosomes.
Journal of Cell Biology. 211, 159-172 (2015b).
Yoshida S., et al.,Redox regulates mammalian target of rapamycin complex 1 (mTORC1) activity bymodulating the TSC1/TSC2-Rheb GTPase pathway.
Journal of Biological Chemistry. 286, 32651-32660 (2011).
Yoshida S., et al., Sequential signaling in plasma-membrane domains during macropinosome formation in macrophages.
Journalof Cell Science.122, 3250-3261 (2009).
Yoshida S., et al., Microtubule-severing activity of Shigella is pivotal for intracellular spreading.
Science. 314, 985-989. (2006).
Yoshida S. and Sasakawa C.Exploiting host microtubule dynamics: A new aspect of bacterial invasion.
Trends in Microbiology. 11, 139-143. (2003).
Yoshida S., et al., Shigella deliver an effector protein to trigger host microtubule destabilization, which promotesRac1 activity and efficient bacterial internalization.
TheEMBO Journal.21, 2923-2935 (2002).
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