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个人概况：
2013年博士毕业于中国科学技术大学（导师：施蕴渝院士）。2013-2019年在清华大学从事博士后研究（导师：施一公院士和颜宁院士）。2019-2020年在西湖大学任助理研究员。2021年加入南开大学，药物化学生物学国家重点实验室/生命科学学院双聘，博士生导师。实验室主要运用结构生物学的方法，结合生物化学与细胞生物学等其它方法，研究参与重大生命进程的重要膜蛋白的结构与工作机理，尤其是与人类疾病相关的重要膜蛋白。至今为止，以第一作者/共同通讯作者在Nature，PNAS，Nature Communications，Trends in Biochemical Sciences, Biochemical Journal等期刊发表研究论文。
研究方向：
1.细胞内重要信号通路中的关键膜受体的调节机制研究。
2.生命进程中关键跨膜运输蛋白的结构与工作机制研究。
招生方向：蛋白质结构与功能
(#equalcontribution; *corresponding author)
[1]Gong D#*, Chi X#,Wei J#, Zhou G, Huang G, Zhang L, Wang R, Lei J, Chen, S*, Yan N*. Modulation of cardiac ryanodine receptor 2by calmodulin. Nature. 2019; 572 (347-351).(F1000recommended) (2020IF:42.778)
[2]Chi X#, Gong D#*,Ren K, Zhou G, Huang G, Lei J, Zhou Q, Yan N*. Molecular basis for the allosteric regulation of ryanodine receptor 2channel gating by key modulators. Proc.Natl. Acad. Sci. USA. 2019; 116(25575-25582). (2020IF:9.412)
[3]Gong D#*, Chi X#, Ren K#,Huang G, Zhou G, Yan N, Lei J, Zhou Q*.Structure of the human plasma membrane Ca2+-ATPase1 in complex with its obligatory subunit neuroplastin. Nat. Commun. 2018; 9 (3623). (2020IF:12.121)
[4]Gong D, Yang F, Li F, Qian D, Wu M, Shao Z, Wu M, Wu J, Shi Y*. Crystal structure and functionalcharacterization of the human RBM25 PWI domain and its flanking basic region.Biochem. J. 2013; 450 (85-94). (2020IF:4.097)
[5]Gong D*, Yan N*, Ledford H*. Structural modulation of cardiac andskeletal ryanodine receptors. TrendsBiochem Sci. 2020; S0968-0004(20)30294-2. (2020IF: 14.732)
[6]Shao Z#, Yan W#, Peng J, Zuo X, Zou Y, Li F, Gong D, Ma R, Wu J, Shi Y, ZhangZ, Teng M, Li X, Gong Q*. Crystalstructure of tRNA m1G9 methyltransferase Trm10: insight into the catalyticmechanism and recognition of tRNA substrate. Nucleic. Acids Res. 2014; 42 (509-525). (2020IF:11.501)
[7]Zou Y, Shao Z, Peng J, Li F, Gong D,Wang C, Zuo X, Zhang Z, Wu J, Shi Y, Gong Q*. Crystal structure of triple-BRCT-domain of ECT2 and insights into thebinding characteristics to CYK-4. FEBSLett. 2014; 588 (2911-2920). (2020IF:3.057)
[8]Shao Z, Li F, Sy SM, Yan W, Zhang Z, GongD, Wen B, Huen MS, Gong Q, Wu J, Shi Y*. Specific recognition of phosphorylated tail of H2AX by the tandem BRCTdomains of MCPH1 revealed by complex structure. J. Struct. Biol. 2012; (2020IF:3.071)
[9]Chen J#, Wang Z#, Guo X#, Li F, Wei Q, Chen Q, Gong D, Xu Y, Chen W, Liu Y, Kang J*, Shi Y*. Tripartite motif-containing 66 reads theunmodified H3R2K4 and H3K56ac to respond to DNA damage and safeguard genomicstability in embryonic stem cells. Nat.Commun. 2019; 9 (4273). (2020IF:12.121)
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