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个人概况：
教育部新世纪优秀人才，第十三届天津青年科技奖获得者，美国康奈尔大学唐氏·康奈尔-中国学者。南开大学生物化学学士，香港科技大学生物化学博士及博士后。博士学位和博士后研究都是在张明杰院士的指导下完成。
研究方向为基因表达调控与疾病。先后主持和参加国家重大研究计划课题、国家或省部级基金等14项。在Nat Commun、Nat Struct Mol Biol、PNAS、Cell Res、Nucleic Acids Res、Cell Disc、Structure和JBC等国际知名期刊上发表SCI论文近50篇，总引用次数超过1340次。多次在国内外学术会议上作邀请报告，担任Nat Struct Mol Biol、Nat Commun、Nucleic Acids Res等期刊的审稿人。
研究方向：
基因表达调控与疾病：
1. 组蛋白修饰复合物的装配机理；
2. 染色质变构的调节机制；
3. 与人类重大疾病相关蛋白的作用机理。
招生方向：蛋白质结构与功能
1．教育部新世纪优秀人才支持计划，负责人，50万元。（2007.4-2011.5）（已完成）
2. 天津市自然科学基金面上项目“关于L27结构域的结构与功能的研究”，负责人,8万元。（2007.7-2009.9）(已结题)
3. 国家科技部973项目“具有重大意义的蛋白质及其复合物的三维结构和功能研究”，学术骨干，150万元。（2007.7-2011.6）（已结题）
4．国家自然科学基金青年基金项目“GRIP1 PDZ23超模块的结构与功能研究”，负责人，17万元。（2008.1-2010.12）（已结题）
5．天津市自然科学基金重点项目“与老年性痴呆相关的X11s/Mints蛋白家族的功能研究”,负责人，20万元。（2008.4-2011.3）（已结题）
6．国家科技部973项目子课题“表观遗传调控过程中重要蛋白的结构与功能研究”，负责人，359万元。（2009.1-2013.8）（已结题）
7. 国家自然科学基金科学部主任基金“老年痴呆症中关键蛋白X11beta/Mint-2的结构与功能研究”，负责人，10万元。（2012.1-2012.12）（已结题）
8. 基本科研业务费平台重大科研项目“基于蛋白结构的创新药物研究”，负责人，65万元。（2012.10-2013.10）（已结题）
9. 国家自然科学基金面上项目“延伸体（Elongator）复合物的装配机理及功能研究”，负责人，90万元。（2013.1-2016.12）（已结题）
10. 国家科技部973项目“神经生长与信息传递重要蛋白质复合体的结构生物学研究”，学术骨干，266万元。（2014.1-2018.8）（已结题）
11. 天津科委科技创新体系及条件平台建设计划“肺纤维化研发平台建设”，负责人，200万元。（2014.10-2016.9）（已结题）
12. 国家自然科学基金面上项目“Paf1复合物（PAF1C）的装配机理及功能机制研究”，负责人，90万元。（2015.1-2018.12）（已结题）
13. 国家自然科学基金面上项目“染色质重塑BAF复合体中四元核心复合物的装配机理及功能机制研究”，负责人，71.6万元。（2017.1-2020.12）
14. 天津市自然科学基金一般项目“小延伸复合物中关键亚基ICE1多聚化的结构基础及功能研究”，负责人，20万元。（2020.4-2023.3）
SELECTED PUBLICATIONS: (listed the first or corresponding author only)
1.“Supramodular structure and synergistic target binding of the N-terminal tandem PDZ domains of PSD-95”, Long, J., Tochio, H., Wang, P., Fan J.-S,. Sala, C., niethammer, M., Sheng, M. and Zhang, M., J. Mol. Biol., 327(1): 203-214 (2003).
2.“The tetrameric L27 domain complex as an organization platform for supramolecular assemblies”, Feng, W.&,Long, J.&(equal contribution), Fan, J,-S., Suetake, T., Zhang, M., Nat. Struct. Mol. Biol., 11(5):475-480 (2004).
3． “A unified assembly mode revealed by the structures of tetrameric L27 domain complexes formed by mLin-2/mLin-7 and Patj/Pals1 scaffold proteins”, Feng, W.&, Long, J.&(equal contribution), Zhang, M.,Proc. Natl. Acad. Sci. USA, 102(19): 6861-6866 (2005).
4.“Autoinhibition of X11/Mint Scaffold Proteins Revealed by the Closed Conformation of the PDZ Tandem”, Long, J., Feng, W., Wang, R., Chan, L.-N., Fanny, Ip. Xia, J., Nancy, Ip. Zhang, M., Nat. Struct. Mol. Biol., 12(8): 722-728 (2005).
5.“Supramodular nature of GRIP1 revealed by the structure of its PDZ12 tandem in complex with the carboxyl tail of Fras1”, Long, J., Wei, Z., Feng, W., Yu, C., Zhao, Y. –X., Zhang, M., J. Mol. Biol., 375(5):1457-1468 (2008).
6.“Structural basis of b-catenin Recognition by Tax-interaction Protein-1”, Zhang, J., Yan, X., Shi, C., Yang, X., Guo, Y., Tian, C., Long, J.*, Shen, Y.*, J. Mol. Biol., 384(1): 255-263 (2008). (*: Co-corresponding author).
7. “Molecular Mechanism of Inward Rectifier Potassium Channel 2.3 Regulation by Tax-interacting Protein-1”, Yan, X., Zhou, H., Zhang, J., Shi, C., Xie, X., Wu, Y., Tian, C., Shen, Y.*, Long, J.*, J. Mol. Biol., 392(4): 967-976 (2009).
8. “Structural basis for tandem L27 domain-mediated polymerization”, Yang, X., Xie, X., Chen, L., Zhou, H., Wang, Z., Zhao, W., Tian, R., Zhang, R., Tian, C., Long. J.*, Shen, Y.*, FASEB J., 24(12): 4806-4815 (2010).
9. “The structural basis for the oligomerization of the N-terminal domain of SATB1”, Wang, Z., Yang, X., Chu, X., Zhang, J., Zhou, H., Shen, Y.*, Long, J.*, Nucleic Acids Res., 40(9): 4193-4202 (2012).
10. “Structure of an L27 domain heterotrimer from the cell polarity complex Patj/Pals1/Mals2 reveals a mutually independent L27 domain assembly mode”, Zhang, J., Yang, X., Wang, Z., Zhou, H., Xie, X., Shen, Y.*, Long, J.*, J. Biol. Chem., 287(14): 11132-11140 (2012).
11. “Rational design of a tetrameric Protein to enhance interactions between self-assembled fibers confers molecular hydrogels”, Zhang, X., Chu, X., Wang, L., Wang, H., Liang, G., Zhang, J., Long, J.*, Yang, Z.*, Angew. Chem. Int. Ed., 51(18): 4388-4392 (2012).
12. “Crystal structure of Elongator subcomplex Elp4-6”, Lin, Z., Zhao, W., Diao, W., Xie, X., Wang, Z., Zhang, J., Shen, Y.*, Long, J.*, J. Biol. Chem.287(25): 21501-21508 (2012).
13. “Open-closed mechanism of Mint2 regulates APP metabolism”, Xie, X., Yan, X., Wang, Z., Zhou, H., Diao, W., Zhou, W., Long, J.*, Shen, Y.*, J. Mol. Cell Biol.5(1): 48-56 (2013).
14. “Multifunctional biohybrid hydrogels for cell culture and cotrolled drug release”, Wang, H., Han, A., Cai, Y., Xie, Y., Zhou, H.*, Long, J.*, Yang, Z.*, Chem. Commun., 49(67): 7448-7450 (2013).
15. “Growth stimulation of bacterium Delftia by a peptide hydrogel”, Du, X., Wu, Z.,Long, J.*, Wang, L.*, RSC Adv., 3(40): 18259-18262 (2013).
16. “Structural insights into Paf1 complex assembly and histone binding”, Chu, X., Qin, X., Xu, H., Li, L., Wang, Z., Li, F., Xie, X., Zhou, H., Shen Y.*, Long, J.*, Nucleic Acids Res., 41(22): 10619-10629 (2013).
17. “Rational design of multifunctional hetero-hexameric proteins for hydrogel formation and controlled delivery of bioactive molecules”, Zhang, X., Zhou, H., Xie, Y., Ren, C., Ding, D.*, Long, J.*, Yang, Z.*, Adv. Healthc. Mater., 3(11): 1804-1811 (2014).
18. “Crystal structure of the Ubiquitin-like domain-CUT repeat-like tandem of special AT-rich sequence binding protein 1 (SATB1) reveals a coordinating DNA-binding mechanism”, Wang, Z., Yang, X., Guo, S., Yang, Y., Su, X-C., Shen, Y.*, Long, J.*, J. Biol. Chem., 289(40): 27376-27385 (2014).
19. “A genetically modified protein-based hydrogel for 3D culture of AD293 cells”, Du, X., Wang, J., Diao, W., Wang, L., Long, J.*, Zhou, H.*, PLoS One, 9(9): e107949 (2014).
20. “The Elp2 subunit is essential for Elongator assembly and functional regulation”, Dong, C., Lin, Z., Diao, W., Li, D., Chu, X., Wang, Z., Zhou, H., Xie, Z., Shen, Y.*, Long, J.*, Structure, 23(6): 1078-1086(2015).
21. “Angiomotin binding-induced activation of Merlin/NF2 in the hippo signaling pathway”, Li, Y., Zhou, H., Li, F., Chan, S., Lin, Z., Wei, Z., Yang, Z., Guo, F., Lim, C., Xing, W., Shen, Y., Hong, W., Long, J.*, Zhang, M.*, Cell Res., 25(7): 801-817 (2015).
22. “Dimerization of elongator protein 1 is essential for Elongator complex assembly”, Xu, H., Lin, Z., Li, F., Diao, W., Dong, C., Zhou, H., Xie, X., Wang, Z., Shen, Y.*, Long, J.*, Proc. Natl. Acad. Sci. USA, 112(34): 10697-10702 (2015).
23. “Self-assembly molecular chaperone to concurrently inhibit the production and aggregation of amyloid b peptide associated with Alzheimer's disease”, Hang, F., Qu A., Yang H., Zhu L., Zhou, H., Liu J., Long J.*, and Shi L.*, Acs Macro lett., 7: 983-989 (2018).
24. “Paf1 and Ctr9 subcomplex formation is essential for Paf1 complex assembly and functional regulation”, Xie Y., Zheng M., Chu X., Chen Y., Xu H., Wang J., Zhou, H.*, Long J.*, Nat. Commun., 9(1): 3795 (2018).
25. “ Treatment with Humanized Selective CD19CAR-T Cells Shows Efficacy in Highly Treated B-ALL Patients Who Have Relapsed after Receiving Murine-Based CD19CAR-T Therapies”, Zhao Y., Liu Z., Wang X., Wu H., Zhang J., Yang J., Zhang F., Liu L.,Long J.*, Lu P.*, Chen Z.*, Clin Cancer Res., 25(18): 5595-5607 (2019).
26. “A Heterotrimeric SMARCB1-SMARCC2 Subcomplex is Required for the Assembly and Tumor Suppression Function of the BAF Chromatin-remodeling Complex”, Chen, G., Zhou, H.*, Liu, B., Wang, Y., Zhao, J., Giancotti, F.*, Long, J.*, Cell Discov., 6:66, (2020).
For more information about the published papers, please click the website in: https://www.researchgate.net/profile/Jiafu_Long
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