紧密围绕“精准医学”这一主题，以高分子化学和生物医学交叉融合为基础，致力于在分子及超分子水平上探索全新的传感/激活机制和制备策略，用于按需定制生命体系适用的有机高/超分子光功能诊疗材料，并为该类材料的化学可控合成与功能调制建立分子基础。近四年以独立/最后通讯发表多篇研究论文(篇均影响因子11.938)，代表性工作包括JACS, Angew. Chem. Int. Ed., Adv. Funct. Mater., ACS Nano, Small等。

2021

30. C. Yang, M. H. Su, P. Luo, Y. N. Liu, F. Yang, C. H. Li* “A Photosensitive Polymeric Carrier with a Renewable Singlet Oxygen Reservoir Regulated by Two NIR Beams for Enhanced Antitumor Phototherapy”
Small 2021, DOI: 10.1002/smll.202101180. [in press] 

29. M. H. Su,# Q. J. Han,# X. S. Yan, Y. N. Liu, P. Luo, W. H. Zhai, Q. Z. Zhang*, L. Y. Li, C. H. Li* “A Supramolecular Strategy to Engineering a Non-photobleaching and Near-Infrared Absorbing Nano-J-Aggregate for Efficient Photothermal Therapy”
ACS Nano 2021, 15, 5032-5042. [Link] (# These authors contributed equally)

2020

28. X. S. Yan,# M. H. Su,# Y. N. Liu, Y. K. Zhang, H. Zhang, C. H. Li* “Molecularly Engineered Hierarchical Nanodisc from Antiparallel J−stacked BODIPY Conjugates: Application to Theranostics with Mutually Beneficial Properties”
Adv. Funct. Mater. 2021, 31, 2008406. [Link] (# These authors contributed equally)

27. Y. S. Zhang, J. Q. Zhang, M. H. Su, C. H. Li* “Rational Molecular Design of a Reversible BODIPY-Based Fluorescent Probe for Real-Time Imaging of GSH Dynamics in Living Cells”
Biosens. Bioelectron. 2021, 175, 112866. [Link] 

26. M. Liu,# W. H. Zhai,# H. L. Chen, H. Zhang, C. H. Li* “Halogen Effects-Induced Bright D-π-A Fluorophore as Scaffold for NIR Fluorogenic Probes with High Contrast”
Anal. Chem. 2020, 92, 10792-10799. [Link] (# These authors contributed equally)

25. M. H. Su, X. S. Yan, X. Guo, Q. W. Li, Y. S. Zhang, C. H. Li* “Two Orthogonal Halogen-Bonding Interactions Directed 2D Crystalline Supramolecular J-Dimer Lamellae”
Chem. Eur. J. 2020, 26, 4505-4509. [Link] 

24. M. Liu, C. H. Li* “Recent Advances in Activatable Organic Photosensitizers for Specific Photodynamic Therapy”
ChemPlusChem 2020, 85, 948-957. [Link] (Invited Review)

2019

23. M. H. Su, S. X. Li, H. Zhang, J. Q. Zhang, H. L. Chen, C. H. Li* “Nano-Assemblies from J-Aggregated Dyes: A Stimuli-Responsive Tool Applicable to Living Systems”
J. Am. Chem. Soc. 2019, 141, 402-413. [Link]

22. W. H. Zhai, Y. K. Zhang, M. Liu, H. Zhang, J. Q. Zhang, C. H. Li* “Universal Scaffold for an Activatable Photosensitizer with Completely Inhibited Photosensitivity”
Angew. Chem. Int. Ed. 2019, 58, 16601-16609. [Link]
(Selected as Hot Paper) 
(Highlighted by SYNFACTS)

2017

21. H. L. Chen, X. J. He, M. H. Su, W. H. Zhai, H. Zhang, C. H. Li* “A General Strategy Toward Highly Fluorogenic Bioprobes Emitting across the Visible Spectrum”
J. Am. Chem. Soc. 2017, 139, 10157-10163. [Link] 
(Highlighted by JACS Spotlights)

2016

20. X. Yao, L. Chen, J. Ju, C. H. Li, Y. Tian, L. Jiang, and M. J. Liu* “Superhydrophobic Diffusion Barriers for Hydrogels via Confined Interfacial Modification“
Adv. Mater. 2016, 28, 7383-7389. 

Before PI

19. C. H. Li, T. Wu, C. Y. Hong, G. Q. Zhang*, S. Y. Liu* “A General Strategy to Construct Fluorogenic Probes from Charge-Generation Polymers (CGPs) and AIE-Active Fluorogens via Triggered Complexation”
Angew. Chem. Int. Ed. 2012, 51, 455-459. 
(Highlighted by ACS Noteworthy Chemistry)  
(ESI Highly Cited Papers, Web of Knowledge, as of March 2013)

18. C. H. Li, S. Y. Liu* “Polymeric Assemblies and Nanoparticles (NPs) with Stimuli-Responsive Fluorescence Emission Characteristics”
Chem. Comm. 2012, 48, 3262‐3278. 

17. C. H. Li, S. Y. Liu* “Engineering FRET Processes within Synthetic Polymers, Polymeric Assemblies and Nanoparticles via Modulating Spatial Distribution of Fluorescent Donors and Acceptors”
Soft Matter 2012, 8, 7096‐7102.

16. C. H. Li, J. M. Hu, T. Liu, S. Y. Liu* “Stimuli-Triggered Off/On Switchable Complexation between a Novel Type of Charge-Generation Polymer (CGP) and Gold Nanoparticles for the Sensitive Colorimetric Detection of Hydrogen Peroxide and Glucose” 
Macromolecules 2011, 44, 429-431.

15. J. M. Hu, C. H. Li, S. Y. Liu* “Highly Selective Colorimetric and Fluorometric Probes for Fluoride Ions Based on Nitrobenzofurazan-Containing Polymers” 
Macromol. Rapid Commun. 2011, 32, 610-615.

14. C. H. Li, Y. X. Zhang, J. M. Hu, J. J. Cheng*, S. Y. Liu* “Reversible Three-State Switching of Multicolor Fluorescence Emission by Multiple Stimuli Modulated FRET Processes within Thermoresponsive Polymeric Micelles” 
Angew. Chem. Int. Ed. 2010, 49, 5120-5124. 

13. C. H. Li, S. Y. Liu* “Responsive Nanogel-Based Dual Fluorescent Sensors for Temperature and Hg2+ Ions with Enhanced Detection Sensitivity” 
J. Mater. Chem. 2010, 20, 10716-10723. 
(Identified as Journal Hot Paper, as of Oct 2010)

12. J. Yin, C. H. Li, D. Wang, S. Y. Liu* ”FRET-Derived Ratiometric Fluorescent K+ Sensors Fabricated from Thermoresponsive Poly(N-isopropylacrylamide) Microgels Labeled with Crown Ether Moieties” 
J. Phys. Chem. B 2010, 114, 12213-12220.

11. J. M. Hu, C. H. Li, S. Y. Liu* “Hg2+-Reactive Double Hydrophilic Block Copolymer Assemblies as Novel Multifunctional Fluorescent Probes with Improved Performance” 
Langmuir 2010, 26, 724-729.

10. C. H. Li, Z. S. Ge, J. Fang, S. Y. Liu* ”Synthesis and Self-Assembly of Coil-Rod Double Hydrophilic Diblock Copolymer with Dually Responsive Asymmetric Centipede-Shaped Polymer Brush as the Rod Segment” 
Macromolecules 2009, 42, 2916-2924.

9. C. H. Li, J. M. Hu, J. Yin, S. Y. Liu* “Click Coupling Fullerene onto Thermoresponsive Water-Soluble Diblock Copolymer and Homopolymer Chains at Defined Positions” 
Macromolecules 2009, 42, 5007-5016. 
(One of Monthly Most-Read Articles)

8. C. H. Li, Z. S. Ge, H. W. Liu, S. Y. Liu* “Synthesis of Amphiphilic and Thermoresponsive ABC Miktoarm Star Terpolymer via a Combination of Consecutive Click Reactions and Atom Transfer Radical Polymerization”
J. Polym. Sci. Part A: Polym. Chem. 2009, 47, 4001-4013.

7. Y. F. Zhang, C. H. Li, S. Y. Liu* ”One-Pot Synthesis of ABC Miktoarm Star Terpolymers by Coupling ATRP, ROP, and Click Chemistry Techniques” 
J. Polym. Sci. Part A: Polym. Chem. 2009, 47, 3066-3077.

6. H. Liu, C. H. Li, H. W. Liu, S. Y. Liu*”pH-Responsive Supramolecular Self-Assembly of Well-Defined Zwitterionic ABC Miktoarm Star Terpolymers” 
Langmuir 2009, 25, 4724-4734.

5. Y. F. Zhang, H. Liu, H. F. Dong, C. H. Li, S. Y. Liu*”Micelles Possessing Mixed Cores and Thermoresponsive Shells Fabricated from Well-Defined Amphiphilic ABC Miktoarm Star Terpolymers” 
J. Polym. Sci. Part A: Polym. Chem. 2009, 47, 1636-1650.

4. Y. F. Zhang, H. Liu, J. M. Hu, C. H. Li, S. Y. Liu* ”Synthesis and Aggregation Behavior of Multi-Responsive Double Hydrophilic ABC Miktoarm Star Terpolymer” 
Macromol. Rapid Commun. 2009, 30, 941-947.

3. H. Liu, Y. F. Zhang, J. M. Hu, C. H. Li, S. Y. Liu* “Multi-Responsive Supramolecular Double Hydrophilic Diblock Copolymer Driven by Host-Guest Inclusion Complexation between β-Cyclodextrin and Adamantyl Moieties” 
Macromol. Chem. Phys. 2009, 210, 2125-2137. 
(One of Most-Accessed Articles During Aug 2009-July 2010)

2. T. Liu, J. M. Hu, J. Yin, Y. F. Zhang, C. H. Li, S. Y. Liu* “Enhancing Detection Sensitivity of Responsive Microgel-Based Cu(II) Chemosensors via Thermo-Induced Volume Phase Transitions” 
Chem. Mater. 2009, 21, 3439-3446.

1. Y. C. Wang, L. Y. Tang, T. M. Sun, C. H. Li, M. H. Xiong, J. Wang* “Self-assembled micelles of biodegradable triblock copolymers based on poly(ethyl ethylene phosphate) and poly(epsilon-caprolactone) as drug carriers” 
Biomacromolecules 2008, 9, 388-395.