1.  国家自然科学基金青年基金项目：甘草与天然β2受体激动剂治疗哮喘的协同作用机理研究（81001682，2011.01-2013.12，20万 ）

2. 国家自然科学基金面上项目：基于氧化呼吸链的中医清热的化学物质基础及其生物学机制研究（81973449，2020.01-2023.12，55万 ）

3. 国家自然科学基金面上项目：清热解毒核心药对调节免疫配伍相须的分子机制研究（81673616，2017.01-2020.12，57万）

4. “甘草-桔梗”药对治疗气道炎症的协同作用机理研究（81374046，2014.01- 2017.12，70万）

1. Weiyi Zhang, Jie Gao, Man Zhang, Wenjuan Liu,Xiaoyao Ma, Wei Lei, Xiaotao Hou, Erwei Hao, Yuanyuan Hou*, Gang Bai*. Cinnamaldehyde enhances anti-melanomaactivity through covalently binding ENO1 and have synergy effects with dacarbazine.Cancers, 2020, 12: 311.

2. Chuanjing Cheng, Fukui Shen, Guoyu Ding, AinaLiu, Simeng Chu, Yuejiao Ma, Xiaotao Hou, Erwei Hao, Xiaoying Wang, Yuanyaun Hou*, Gang Bai*. Lepidiline Aimproves the balance of endogenous sex hormones and increases fecundity bytargeting HSD17B1. Molecular Nutrition& Food Research, 2020, 64: 1900706.

3. Man Zhang, Xiaoyao Ma, Honglei Xu, Wenbo Wu,Xiaoying Wang, Min Jiang, Yuanyuan Hou*Gang Bai*. A natural AKT inhibitor swertiamarin targets AKT-PH domain, inhibitsdownstream signaling, and alleviates inflammation. FEBS Journal, 2020, 287: 1816-1829.

4. Zhihua Wang, Wenbo Wu, Chenxiang Guan, ShuangGuo, Chaowen Li, Ruixue Niu, Jie Gao, Min Jiang, Liping Bai, Elaine LaihanLeung, Yuanyuan Hou*, ZhihongJiang*, Gang Bai*. 20(s)-Protopanaxatriol promotes the binding of P53 and DNAto regulate the antitumor network via multiomic analysis. Acta Pharmaceutica Sinica B, 2020, 10(6): 1020-1035.

5. Man Zhang, Lili Ye, Wenbo Wu, Kaixin Liu, HaoHuang, Dandan Cheng, Zhihong Jiang, YuanyuanHou*, Gang Bai*. Micelles self-assembled by 3-O-β-D-glucopyranosyllatycodigenin enhances cell membrane permeability, promotes antibioticpulmonary targeting and improves anti-infect efficacy. Journal of Nanobiotechnology, 2020, 18: 140.

6. ShengnanYang, Yuan Zhang, Fukui Shen, Xiaoyao Ma, Man Zhang, YuanyuanHou*, Gang Bai*. The flavonoid baicalin improvesglucose metabolism by targeting the PH domain of AKT and activating AKT/GSK3βphosphorylation. FEBS Letters, 2019 (01.28), 593 (2): 175-186.

7. YunbingShen, Shengnan Yang, Xueyan Hu, Man Zhang, Xiaoyao Ma,Zhihua Wang, YuanyuanHou*, Gang Bai*.Natural product puerarin activates Akt and ameliorates glucose and lipidmetabolism dysfunction in hepatic cells. Journal ofFunctional Foods, 2019, 55: 296-304.

8. YuanZhang, Zhihua Wang, Xiaoyao Ma, Shengnan Yang, XueyanHu, Jin Tao, Yuanyuan Hou*, Gang Bai*. Glycyrrhetinic acid binds to the conserved P-loop region andinterferes with the interaction of RAS-effector proteins. ActaPharmaceutica Sinica B, 2019, 9 (2): 294-303.

9. Zhihua Wang, Unchol Kim, Yanting Jiao, Chaowen Li, Yingying Guo, Xiaoyao Ma, Ming Jiang, Zhihong Jiang, Yuanyuan Hou*, Gang Bai*. Quantitative proteomics combine with affinity MS revealed the molecular mechanism of ginsenoside anti-tumor effects. Journal of Proteome Research, 2019, 18 (5): 2100-2108.

10. Zhihua Wang, UncholKim, Jinbiao Liu, Chuanjing Cheng, Wenbo Wu, Shuang Guo,YunjiangFeng, Ronald J. Quinn, Yuanyuan Hou*, Gang Bai*. Comprehensive TCMmolecular networking based on MS/MS in silico spectra with integration ofvirtual screening and affinity MS screening for discovering functional ligandsfrom natural herbs. Analytical and Bioanalytical Chemistry,2019, 411(22): 5785-5797.

11. XiaoyaoMa, Aina Liu, Wenjuan Liu, Zhihua Wang, Nianwei Chang, Suyun Li,JianshengLi, Yuanyuan Hou*, Gang Bai*. Analyze and identify Peiminine target EGFRimprove lung function and alleviate pulmonary fibrosis to prevent exacerbationof COPD by phosphoproteomics analysis. Frontiersin Pharmacology, 2019, 10: 737.

12. FukuiShen, Wenbo Wu, Man Zhang, Zhongyao Tang, Hao Huang, Jingrong Wang, Zhihong Jiang, YuanyuanHou*, Gang Bai*. The Micro-PET imaging demonstrates3-O-β-D-glucopyranosyl platycodigenin as an effective metabolize improves thedosimetry of [18F]-Phillygenin in lung tissue. Frontiers in Pharmacology, 2019, 10: 1020.

13.Yanting Jiao, Fukui Shen, Zhihua Wang, Lili Ye, Man Zhang, JieGao, Yuanyuan Hou*, Gang Bai*. Genipin, a natural AKT inhibitor, targets thePH domain to affect downstream signaling and alleviates inflammation.Biochemical Pharmacology, 2019, 170, 113660.

14. Xueyan Hu, Yunbing Shen, Shengnan Yang, Wei Lei,Cheng Luo, Yuanyuan Hou*, Gang Bai*. Metabolite identification ofursolic acid in mouse plasma and urine after oral administration by ultra-highperformance liquid chromatography/quadrupole time-of flight mass spectrometry. RSCAdvances, 2018, 8:6532-6539.

15.Qingxin Cui‡, Yuanyuan Hou‡,Yanan Wang, Xu Li, Yang Liu, Xiaoyao Ma, Zengyong Wang, Weiya Wang, Jin Tao,Qian Wang, Min Jiang, Dongyan Chen, Xizeng Feng*, Gang Bai*. Biodistribution ofarctigenin‑loadednanoparticles designed for multimodal imaging. Journalof Nanobiotechnology, 2017, 15: 27.

16. Zhongyao Tang, Yuanyuan Hou*, XueyanHu, Aina Liu, Leefong Yau, Tiantian Tong, Zhihong Jiang, Gang Bai. Metaboliteidentification and pharmacokinetic study of platycodi radix (Jiegeng) in vivo. RSC Advances, 2017, 7:37459-37466. (SCI IF: 3.108)

17. Xiaoyao Ma, Yuan Zhang, Zengyong Wang, Yunbing Shen,Man Zhang, Quandeng Nie, Yuanyuan Hou*, Gang Bai*.Ursolic Acid,A Natural Nutraceutical Agent, Targets Caspase3 and AlleviatesInflammation-Associated Downstream Signal Transduction.Molecular Nutrition &Food Research, 2017, 61(12): 1700332.

18. Jin Tao, Yuanyuan Hou*, Xiaoyao Ma, Dan Liu,Yongling Tong, Hong Zhou, Jie Gao, Gang Bai*. An integrated global chemomicsand system biology approach to analyze the mechanisms of the traditionalChinese medicinal preparation Eriobotrya japonica-Fritillaria usuriensis dropping pills for pulmonary diseases. BMCComplementary and Alternative Medicine. 2016 Jan 8; 16(1): 4.

19. Yuan Yuan Hou, Yan Nie, Bin Feng Cheng, Jin Tao, Xiao Yao Ma, Min Jiang,Jie Gao, Gang Bai*. Qingfei Xiaoyan Wan, a traditional Chinese medicineformula, ameliorates Pseudomonas aeruginosa-inducedacute lung inflammation by regulation of PI3K/AKT and Ras/MAPK pathways. ActaPharmaceutica Sinica B, 2016, 6(3): 212-221.

20. Guoyu Ding, Yuanyuan Hou*, Jiamin Peng, Yunbing Shen, Min Jiang,Gang Bai. On-line near-infrared spectroscopy optimizing and monitoring biotransformationprocess of γ-aminobutyricacid. Journal of Pharmaceutical Analysis,2016, 6: 171-178.

21. Dan Sun, Yanqi Han, Weiya Wang, Zengyong Wang,Xiaoyao Ma, Yuanyuan Hou*, Gang Bai. Screening and Identification ofCaulis Sinomenii Bioactive Ingredients with Dual-target NF-κB Inhibition andß2-AR Agonizing Activities. Biomedical Chromatography, 2016,30(11):1843-1853.

22. Guoyu Ding, Baiqing Li, Yanqi Han, Aina Liu, Jingru Zhang,Jiamin Peng, Min Jiang, Yuanyuan Hou*, Gang Bai*. A rapidintegrated bioactivity evaluation system based onnear-infrared spectroscopy forquality control of Flos Chrysanthemi. Journal of Pharmaceutical andBiomedical Analysis, 2016, 131: 391-399.

23. Jin Tao, Yan Nie, Yuanyuan Hou*, XiaoyaoMa, GuoyuDing, Jie Gao,Min Jiang, Gang Bai*. Chemomics-Integrated Proteomics Analysis ofJie-Geng-Tang to Ameliorate Lipopolysaccharide-Induced Acute Lung Injury inMice. Evidence-BasedComplementary and Alternative Medicine, 2016, Article ID 7379146.

24. Xiaoyao Ma, ManZhang, Ge Fang, Chuanjing Cheng, Mukuo Wang, Yiman Han, Xiaotao Hou, Erwei Hao,Yuanyuan Hou*, Gang Bai. Ursolic acid reduces hepatocellular apoptosis andalleviates alcohol-induced liver injury via irreversible inhibition of CASP3 invivo. Acta Pharmacologica Sinica, 2020 (10.07), online.

25. Chuan-jing Cheng,Xiao-tao Hou, Er-wei Hao, Nut Palachai, Jintanaporn Wattanathorn, Gang Bai,Yuan-yuan Hou*. Integrated Molecular Network and HPLC-UV-FLD Analysis toExplore Antioxidant Ingredients in Camellia Nitidissima Chi. Journal of FoodScience, 2021, 86: 1396-1305.

26. Ge Fang, Chuanjing Cheng, Manqian Zhang,Xiaoyao Ma, Shengnan Yang, Xiaotao Hou, Jiagang Deng, Yuanyuan Hou*, Gang Bai*.The glucuronide metabolites of kaempferol and quercetin, targeting to the AKTPH domain, activate AKT/GSK3β signaling pathway and improve glucose metabolism.Journal of Functional Foods, 2021, 82: 104501.