导师风采
李静
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个人信息

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  • 副教授
  • 导师类别:硕士生导师
  • 性别: 女
  • 学历:博士研究生
  • 学位:博士

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Contact Information

  • 所属院系:化学学院
  • 所属专业: 化学生物学  、 材料与化工
  • 邮箱 : jinglink@nankai.edu.cn
  • 工作电话 : -

个人简介

Personal Profile

李静,2007年毕业于山东农业大学,同年加入南开大学,讲授本科生课程:《天然药物学》、《药用植物学》、《化学生物学基础及应用》,研究生课程:《课题申请与项目管理》,主要从事:抗癌药物药理学机制研究,药物靶点鉴定和免疫学试剂盒开发等研究。目前以第一作者或通讯作者发表SCI论文20余篇,主持多项国家及企业合作药物研发课题,长期担任“Analytical Chimica Acta”、“Bioorganic & Medicinal Chemistry Letter”的审稿人。 
  • 研究方向Research Directions
化学生物学、天然药物学、药理学
2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行2. 机电结构优化与控制 研究内容:在对机电结构进行分析和优化的基础上,运用控制理论进行结构参数的调整,使结构性能满足设计要求。1. 仿生结构材料拓扑优化设计, 仿生机械设计 研究内容:以仿生结构为研究对象,运用连续体结构拓扑优化设计理论和方法,对多相仿生结构(机构)材料进行整体布局设计。 整体布局设计。
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科研项目
目前主持国家自然科学基金面上项目1项(PKM2激活剂调控p53降低癌症化疗诱发心脏毒性的机制及临床验证)及横向课题1项(天然产物药物靶点鉴定),曾主持国家自然科学基金青年基金1项(糖基化信号途径中OGA的双催化功能及其调节机制),天津市自然科学基金一般项目1项(胰岛素受体信号途径中糖基化蛋白的代谢标记及应用研究),参与国家新药创制重大专项、国家973等项目6项。
研究成果

[1] Guo JS, Wang JY, Chen SH, Deng YP, Gao QY, Liu ZX, Liu J, Lv K, Liu N, Bai GY, Shan CL, Feng XQ *, Li J.*. The natural product micheliolide promotes the nuclear translocation of GAPDH via binding to Cys247 and induces glioblastoma cell death in combination with temozolomide. Biochem Pharmacol. 2025 Jan 23; 233:116759.

[2] Meng Q., Guo J., Lv K., Liu Y., Zhang J., Li M., Cheng X., Chen S., Huo X., Zhang Q. *, Chen Y. *, Li J.*, 5S-Heudelotinone alleviates experimental colitis by shaping the immune system and enhancing the intestinal barrier in a gut microbiota-dependent manner. Acta Pharmaceutica Sinica B, 2024,14(5):2153-2176.

[3] Jin R, Wang J, Li M, Tang T, Feng Y, Zhou S, Xie H, Feng H, Guo J, Fu R, Liu J, Tang Y*, Shi Y, Guo H, Wang Y, Nie F*, Li J.*, Discovery of a Novel Benzothiadiazine-Based Selective Aldose Reductase Inhibitor as Potential Therapy for Diabetic Peripheral Neuropathy. Diabetes. 2024,73(3):497-510.

[4] Lv K., Li M., Sun C., Miao Y., Zhang Y., Liu Y., Guo J., Meng Q., Yao J.*, Zhang G.*, Li J.*, Jingfang Granule alleviates bleomycin-induced acute lung injury via CD200-CD200R immunoregulatory pathway. J Ethnopharmacol, 2023,15, 311:116423.

[5] Guo J., Liu K., Wang J., Jiang H., Zhang M., Liu Y., Shan C., Hu F., Fu W., Zhang C., Li J.*, Chen Y.*, A rational foundation for micheliolide-based combination strategy by targeting redox and metabolic circuit in cancer cells, Biochemical Pharmacology,2022(200): 115037.

[6] Cui Y., Zhang M., Xu H., Zhang T., Zhang S., Zhao X., Jiang P., Li J.*, Ye B., Sun Y., Wang M., Deng Y., Meng Q., Liu Y., Fu Q., Lin J., Wang L.*, Chen Y.*, Elastase Inhibitor Cyclotheonellazole A: Total Synthesis and In Vivo Biological Evaluation for Acute Lung Injury. Journal of Medicinal Chemistry 2022, 73:334.

[7] Liu W., Liu K., Zhang Y., Wang L., Zhang M.*, Li J.*, The Mechanism of Glycosylation in SARS-CoV-2 Infection and Application in Drug Development. Progress in Chemistry, 2021, 33(4):9.

[8] Ding Y, Xue Q, Liu S, Hu K, Wang D, Wang T, Li Y, Guo H, Hao X, Ge W, Zhang Y, Li A, Li J*, Chen Y*, Zhang Q*. Identification of Parthenolide Dimers as Activators of Pyruvate Ki-nase M2 in Xenograft of Glioblastoma Multiforme in vivo. Journal of Medicinal Chemistry, 2020 63 (4): 1597-1611

[9] Guo J., Xue Q., Ma J., Liu K., Ge W., Liu W., Wang J., Zhang M., Li Q., Cai D., Shan C., Zhang C., Liu X., Li J.*, Dimethylaminomicheliolide (DMAMCL) Suppresses the Proliferation of Glioblastoma Cells via Targeting Pyruvate Kinase 2 (PKM2) and Rewiring Aerobic Glycolysis. Frontiers in Oncology, 2019, 9: 993.

[10] Guo J., Zhang G., Ma J., Zhao C., Xue Q., Wang J., Liu W., Wang H., Liu N., Song Q., Li J.*, A detection and identification of O-GlcNAc-modified proteins using 6-azido-6-deoxy-N-acetyl-galactosamine. Organic & Biomolecular Chemistry, 2019,17, 4326-4334.

[11] Li S., Wang J.*, Zang L., Zhu H., Guo J.,Zhang J., Wen L., Chen Y.,Li Y., Chen X., Wang P G.*, Li J.*,Production of Glycopeptide Derivatives for Exploring Substrate Specificity of Human OGA Toward Sugar Moiety. Frontiers in Chemistry, 2019, 6: 646.

[12] Wang H., Guo J., Wang N., Wang J., Xue Q., Wang J., Liu W., Liu K., Cao X ., Zhao W., Xi R., Niu Y., Wang P., Li J.*, Ac4GlcNAcF3, an OGT-tolerated but OGA-resistant regulator for O-GlcNAcylation.  Bioorganic & Medicinal Chemistry Letters, 2019.2.15, 29(6): 802~805.

[13] Li J., Li S., Guo J., Li Q., Long J., Ma C., Ding Y., Yan C., Li L., Wu Z., Zhu H., Li K., Wen L., Zhang Q., Xue Q., Zhao C., Liu N., Ivanov I., Luo M., Xi R., Long H., Wang PG., Chen Y.., Natural Product Micheliolide (MCL) Irreversibly Activates Pyruvate Kinase M2 and Suppresses Leukemia. Journal of Medicinal Chemistry, 2018, 61, 4155−4164.

[14] Jiang K., Zhu H., Li L., Guo Y., Gashash E., Ma C., Sun X., Li J.*, Zhang L.*, Wang PG.*. Sialic acid linkage-specific permethylation for improved profiling of protein glycosylation by MALDI-TOF MS. Analytica Chimica Acta, 2017, 981:53-61.

[15] Jiang K., Zhu H., Xiao C., Liu D., Garrett E., Wen L., Ma C.*, Li J.*, Wang PG.*. Solid-phase reductive amination for glycomic analysis. Analytica Chimica Acta, 2017, 962:32-40.

[16] Wen L., Jiang K., Zheng Y., Zhang M., Kondengaden SM., Li S., Huang K., Li J., Song J., Wang PG. Two-step Chemoenzymatic Detecting N-Acetylneuraminic acid-α(2-3)- galactose Glycans. JACS, 2016, 138 (36): 11473–11476.

[17] Wu Z., Jiang K., Zhu H., Ma C., Yu Z., Li L., Guan W., Liu Y., Zhu H., Chen Y., Li J., Cheng J., Wang PG., Site-directed glycosylation of peptide/protein with homogeneous O-linked eukaryotic N-glycans. Bioconjugate chemistry 2016, 27 (9), 1972–1975.

[18] Li J., Wen L., Zhu H., Li S., Huang K., Li X., Ma C., Qu J., Parameswaran A., Song J., Zhao W., Wang PG. An OGA-resistant Probe Allow Specific Visualization and Accurate Identification of O-GlcNAc-modified Proteins in Cells. ACS Chem Biol, 2016, 11 (11): 3002–3006.

[19] Li S., Zhu H., Wang J., Wang X., Li X., Ma C., Wen L., Yu B., Wang Y., Li J*., Wang PG.* Comparative analysis of Cu (I)-catalyzed alkyne-azide cycloaddition (CuAAC) and strain-promoted alkyne-azide cycloaddition (SPAAC) in O-GlcNAc proteomics. Electrophoresis. 2016, 37(11): 1431-1436.

[20] Li Z., Li T., Dai S., Xie X., Ma X., Zhao W., Li J.* & Wang P. G*. New insights into the pharmacological chaperone activity of C2 — substituted glucoimidazoles for the treatment of gaucher disease. ChemBioChem, 2013, 14 (10): 1239- 1247.

[21] Li T., Guo L., Zhang Y., Wang J., Zhang Z., Li J., Zhang W., Lin J., Zhao W.*, Wang P.G*. Structure-activity relationships in a series of C2-substituted gluco-configured tetrahydroimidazopyridines as β-glucosidase inhibitors. Bioorg Med Chem., 2011,19(7): 2136-2144.


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